LEADER 02307cam0-22004811i-450 001 990004954580403321 005 20210413151107.0 012 $ae.nt o,i- eno- moIt (3) 1559 (R)$2fei$5IT-NA0105: SG 870/C 14 (pt. 1) 012 $a.249 51it 2310 ce67 (C) 1558 (A)$2fei$5IT-NA0105: SG 870/C 14 (pt. 2) 035 $a000495458 035 $aFED01000495458 035 $a(Aleph)000495458FED01 035 $a000495458 100 $a19990604g15581559km-y0itay50------ba 101 0 $alat 102 $aIT 140 $aa-----------------bb0------- 200 1 $aC. Plinii Secundi Naturalis historiae libri trigintaseptem, a Paulo Manutio multis in locis emendati. Castigationes Sigismundi Gelenii. Index plenissimus 210 $aVenetiis$capud Paulum Manutium, Aldi F.$d1558-1559 215 $a2 pt. ([14] c., 976 col., [18] c.; [66] c.)$cill.$dfol. 306 $aMarca (Z45) sui front. 307 $aSegn.: A? B? a-z? A-R? S? 3a-3c?; A-L? 312 $aTit. della pt. 2.: Index in C. Plinii secundi Naturalem historiam, ad exemplum Ioan. Camertis, mutatis quibusdam quĉ ad hanc editionem non congruebant, nonnullis etiam adiectis 321 1 $aEDIT16,$cCNCE 28055 423 0$12001$aCastigationes Sigismundi Gelenii 423 0$12001$aIndex plenissimus 500 10$aHistoria naturalis$m$912698 517 1 $aNaturalis historiae libri trigintaseptem, a Paulo Manutio multis in locis emendati. Castigationes Sigismundi Gelenii. Index plenissimus 517 1 $aIndex in C. Plinii secundi Naturalem historiam, ad exemplum Ioan. Camertis, mutatis quibusdam quĉ ad hanc editionem non congruebant, nonnullis etiam adiectis 620 $aItalia.$dVenezia 676 $a870.01$v22$zita 700 1$aPlinius Secundus,$bGaius$f<23-70>$0208975 702 1$aManuzio,$bPaolo$d<1512-1574> 702 1$aGelen,$bSigmund$f<1497-1554> 719 00$aManuzio,$gPaolo$4650 801 0$aIT$bUNINA$gRICA$2UNIMARC 856 4 $zVisualizza la versione elettronica in SBNWeb$uhttps://books.google.it/books?id=pjdbg_aaMTIC&printsec=frontcover&hl=it&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false$e20210412 901 $aAQ 912 $a990004954580403321 952 $aSG 870/C 14$bs. i.$fFLFBC 959 $aFLFBC 996 $aHistoria naturalis$912698 997 $aUNINA LEADER 03459nam 2200397z- 450 001 9910220044003321 005 20210211 035 $a(CKB)3800000000216337 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53834 035 $a(oapen)doab53834 035 $a(EXLCZ)993800000000216337 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Dynamics at the Immunological Synapse 210 $cFrontiers Media SA$d2017 215 $a1 online resource (120 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-133-X 330 $aThe immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies. 606 $aMedicine and Nursing$2bicssc 610 $acytoskeleton dynamics 610 $aendosomal dynamics 610 $aImmunological Synapse 610 $aintracellular signalling 615 7$aMedicine and Nursing 700 $aPedro Roda-Navarro$4auth$01315278 702 $aAndres Alcover$4auth 702 $aVincenzo Di Bartolo$4auth 906 $aBOOK 912 $a9910220044003321 996 $aMolecular Dynamics at the Immunological Synapse$93032332 997 $aUNINA LEADER 01751nam0 22004453i 450 001 PUV0283813 005 20251003044312.0 010 $a0198533039 100 $a20150221d1959 ||||0itac50 ba 101 | $aeng 102 $agb 181 1$6z01$ai $bxxxe 182 1$6z01$an 183 1$6z01$anc$2RDAcarrier 200 1 $aConduction of heat in solids$fby H. S. Carslaw and J. C. 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C.$3MILV194509$zJaeger, John Conrad <1907-1979> 801 3$aIT$bIT-000000$c20150221 850 $aIT-BN0095 901 $bNAP 01$cSALA $n$ 912 $aPUV0283813 950 0$aBiblioteca Centralizzata di Ateneo$d 01SALA 536.23 CAR co$e 0104 0000017715 VMA 1 v.$fA $i20110502 977 $a 01 996 $aConduction of heat in solids$9345623 997 $aUNISANNIO