LEADER 05094nam 2200589 450 001 9910787001503321 005 20230807212105.0 010 $a1-908230-53-3 035 $a(CKB)3710000000268191 035 $a(EBL)1887934 035 $a(SSID)ssj0001410696 035 $a(PQKBManifestationID)11906726 035 $a(PQKBTitleCode)TC0001410696 035 $a(PQKBWorkID)11374762 035 $a(PQKB)10983977 035 $a(MiAaPQ)EBC1887934 035 $a(MiAaPQ)EBC5897804 035 $a(Au-PeEL)EBL5897804 035 $a(OCoLC)896842821 035 $a(EXLCZ)993710000000268191 100 $a20191011d2015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aLeishmania $ecurrent biology and control /$fedited by Subrata Adak and Rupak Datta 210 1$aNorfolk, England :$cCaister Academic Press,$d[2015] 210 4$dİ2015 215 $a1 online resource (258 p.) 300 $aDescription based upon print version of record. 311 $a1-908230-52-5 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Current Books of Interest; Preface; 1: Modulation of Host Cell miRNA Expression During Leishmania Infection and Emergence of miRNA as a New Therapeutic Molecule; miRNA-mediated gene regulation in metazoan animals; miRNA as regulator of cholesterol metabolism in mammals; Cholesterol regulates pathogenesis of Leishmania donovani; Leishmania-mediated changes in cholesterol production in mammals; miRNA expression affected by parasite; Mechanism of miRNA alteration by Leishmania; Factors important for host cell miRNA alteration during infection; miRNA as therapeutic agent 327 $aFuture of miRNA as a therapeutic agent against visceral leishmaniasis2: Heat Shock Proteins of Leishmania: Chaperones in the Driver's Seat; Introduction: heat shock proteins; Heat shock proteins in Leishmania spp.; Leishmania and the cell stress; The pitfalls of analogy-based assumptions; The chaperone machinery and signal transduction in Leishmania; Open questions; Future trends; Acknowledgements; 3: Role of Iron in Leishmania-Macrophage Interaction; Introduction; Aqueous chemistry and toxicity of iron; Role of iron in physiology; Role of iron in the host-parasite interaction 327 $aSpecial need of iron for LeishmaniaMammalian iron homeostasis components important for sequestering iron; Regulation of cellular iron metabolism of mammalian host; Source of host iron and its acquisition systems in Leishmania; Summary and future aspects; 4: Oxidative and Nitrosative Stress Response in Leishmania; Introduction; Sources of superoxide and hydrogen peroxide in Leishmania; Targets of reactive oxygen species in Leishmania; Defence against reactive oxygen species; Nitrosative stress in Leishmania; Generation of reactive nitrogen species 327 $aTargets of reactive nitrogen species (RNS) in LeishmaniaCellular defences against nitrosative stress in Leishmania; Conclusion; Future perspectives; 5: Cell Death in a Kinetoplastid Parasite, the Leishmania spp.; Introduction; Life cycle of Leishmania spp.; Treatment of leishmaniasis; Programmed cell death (PCD); Programmed cell death in protozoan parasites; Relevance of studying cell death in Leishmania; Apoptosis in Leishmania; Natural cell death during cell cycle; Induction of cell death by anti-leishmanial drugs; Oxidative stress induced cell death 327 $aRole of apoptotic mimicry and apoptosis in LeishmaniaAutophagy in Leishmania; Future trends; Conclusion; 6: Elucidating the Strategies of Immune Evasion by Leishmania; Introduction; Defying recognition by the host: modulation of Toll-like receptor-mediated signalling; Deactivation of host signalling: mitogen-activated protein (MAP) kinases and phosphatases; Disarming the enemy: inhibition of host microbicidal molecules; Delaying phagosome maturation: buying time for promastigote to amastigote conversion; Creating a favourable environment: polarization of Th (T-helper cell) response 327 $aSuppression of antigen presentation: escaping cytotoxic T-cell response 330 $aEvery year, with an estimated 1.3 million new cases and more than 20,000 deaths, Leishmaniasis continues to be a menace in countries across the globe. With the absence of an anti-Leishmania vaccine - along with the toxicity of current anti-parasite drugs and coupled with the rapid emergence of drug resistant Leishmania strains - there remains significant challenges for disease control. This has spurred a plethora of research initiatives into parasite biology, parasite-host interaction, mechanisms of disease pathogenesis, drug development, and the molecular mechanism of drug resistance. Insight 606 $aLeishmania 615 0$aLeishmania. 676 $a593.18 702 $aDatta$b Rupak 702 $aAdak$b Subrata 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787001503321 996 $aLeishmania$93780008 997 $aUNINA LEADER 01406nas0 22003493i 450 001 MIL0016786 005 20251003044218.0 011 $a0887-0403 100 $a19891107f ||||0itac50 ba 101 | $aeng 102 $aus 110 $aazu|||||||| 181 1$6z01$ai $bxxxe 182 1$6z01$an 200 1 $aWorld resources ...$ea report$fby The World resources institute and The International institute for environment and development 210 $aNew York$cBasic books 215 $a v.$cill.$d28 cm 300 $aAnnuale, biennale dal 1988 300 $aIn cop.: An assessment ofthe resource base that supports the global economy 300 $aSospeso nel 1989/90 300 $aDescrizione basata su: 1986 326 $aAnnuale 421 1$1001MIL0320983$12001 $aWorld resources 1996-97$fa joint publication by the World resources institute$gthe United Nations environment programme$gthe United Nations development programme$gthe World Bank 676 $a338.005$9PUBBLICAZIONI IN SERIE DI PRODUZIONE$v20 710 02$aWorld resource institute$3MILV016436$4070$0791720 711 02$aInternational institute for environment and development$c $3RMBV176303$4070$0329313 791 02$aWRI$3MILV019041$zWorld resource institute 801 3$aIT$bIT-000000$c19891107 912 $aMIL0016786 977 $a 01 996 $aWorld resources ..$91770053 997 $aUNISANNIO