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(precedente collocazione: GUERRAZZI C 198)$fB $h20080228$i20080228 977 $a 01 996 $aAcquisto di azioni proprie$9416977 997 $aUNISANNIO LEADER 05438nam 22005655 450 001 9910253896103321 005 20251113175442.0 010 $a81-322-2837-5 024 7 $a10.1007/978-81-322-2837-0 035 $a(CKB)3710000000873125 035 $a(DE-He213)978-81-322-2837-0 035 $a(MiAaPQ)EBC4707181 035 $a(PPN)195514130 035 $a(EXLCZ)993710000000873125 100 $a20160930d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges /$fedited by Sanjeeva Srivastava 205 $a1st ed. 2016. 210 1$aNew Delhi :$cSpringer India :$cImprint: Springer,$d2016. 215 $a1 online resource (XI, 118 p. 28 illus. in color.) 311 08$a81-322-2835-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aChapter 1: Exigencies of biomarker research in developing world: A focus on the dearth of biobanking resources -- Chapter 2: Geographic pervasiveness of cancer: Prospects of novel biomarker and therapeutic research in developing countries using OMICs approaches -- Chapter 3: Omics data processing and analysis -- Chapter 4: Basics of mass spectrometry and its applications in biomarker discovery -- Chapter 5: Angel Philanthropy and Crowdfunding to Accelerate Cancer Research in Developing World -- Chapter 6: Delivering on the Promise of Bioeconomy in Developing World: Link it with Social Innovation and Education -- Chapter 7: Role of proteomics in characterization of biosimilar products -- Chapter 8: Regulatory norms and intellectual property rights for biomarker research. 330 $aThis book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker ?life cycle? with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being usedfor biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With theneed for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of ?social innovation? to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and prominence recently due to their immense potential in clinical and pharmaceutical innovation literatures. The broader goal post-biomarker discovery is to translate their use in clinics. However, the road from bench-to-bed side is arduous and complex that is subject to oversight from various national and international regulatory bodies. Chapter 8 underscores these regulatory science considerations and provides a concise overview on intellectual property rights in biomarker discovery. Thus, this book contributed by eminent biomarker scientists, clinicians, translational researchers and social scientists holistically covers the various facets of the biomarker discovery journey from ?cell to society? in developing world. The lessons learned and highlighted here are of interest to the life sciences community in a global and interdependent world. 606 $aCancer 606 $aProteins 606 $aDiseases 606 $aMedical microbiology 606 $aCancer Biology 606 $aProtein Biochemistry 606 $aDiseases 606 $aMedical Microbiology 615 0$aCancer. 615 0$aProteins. 615 0$aDiseases. 615 0$aMedical microbiology. 615 14$aCancer Biology. 615 24$aProtein Biochemistry. 615 24$aDiseases. 615 24$aMedical Microbiology. 676 $a614.5999 702 $aSrivastava$b Sanjeeva$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910253896103321 996 $aBiomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges$92517334 997 $aUNINA