LEADER 01000nam a2200229 i 4500 001 991004138209707536 008 090210s1996 it 001 0 ita d 035 $ab13809544-39ule_inst 040 $aFacoltà SSPT$bita 082 0 $a320.44 100 1 $aCuccodoro, Enrico$0249532 245 13$aIl mito del cavallo di Troia :$b le suggestioni della riforma istituzionale in Italia di fronte alle altrui esperienze costituzionali /$cEnrico Cuccodoro 260 $aSulmona :$bMarsica Domani,$c1996 300 $a60 p. ;$c22 cm 500 $aSul verso del front.: Universita degli studi di Teramo. Facolta di scienze politiche 651 4$aItalia$xOrdinamento istituzionale$xRiforma 907 $a.b13809544$b02-04-14$c10-02-09 912 $a991004138209707536 945 $aLE021 320.44 CUC01.02$g1$i2020000010975$lle021$og$pE8.00$q-$rn$s- $t0$u0$v0$w0$x0$y.i14927901$z10-02-09 996 $aMito del cavallo di Troia$91225972 997 $aUNISALENTO 998 $ale020$b10-02-09$cm$da $e-$fita$git $h3$i0 LEADER 05403nam 2200721 a 450 001 9910970688203321 005 20210525125108.0 010 $a9781283735063 010 $a1283735067 010 $a9780123865380 010 $a0123865387 035 $a(CKB)2670000000172228 035 $a(EBL)892228 035 $a(OCoLC)787852041 035 $a(SSID)ssj0000623278 035 $a(PQKBManifestationID)12293004 035 $a(PQKBTitleCode)TC0000623278 035 $a(PQKBWorkID)10648031 035 $a(PQKB)11457961 035 $a(Au-PeEL)EBL892228 035 $a(CaPaEBR)ebr10546058 035 $a(CaONFJC)MIL404756 035 $a(PPN)182571491 035 $a(FR-PaCSA)88812223 035 $a(MiAaPQ)EBC892228 035 $a(FRCYB88812223)88812223 035 $a(EXLCZ)992670000000172228 100 $a20120123d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPractical process research and development $ea guide for organic chemists /$fNeal G. Anderson 205 $a2nd ed. 210 $aAmsterdam ;$aBoston $cAcademic Press$d2012 215 $a1 online resource (489 p.) 300 $aRev. ed. of: Practical process research & development. c2000. 311 08$a9781493301256 311 08$a149330125X 311 08$a9780123865373 311 08$a0123865379 320 $aIncludes bibliographical references and indexes. 327 $aFront Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETY 327 $aREFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTS 327 $aIII. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCES 327 $aChapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONS 327 $aVII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONS 327 $aVI. TEMPERATURE CONTROL 330 $a"Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and green chemistry"--$cProvided by publisher. 606 $aChemical processes 615 0$aChemical processes. 676 $a541/.39 676 $a541.39 700 $aAnderson$b Neal G$01797708 701 $aAnderson$b Neal G$01797708 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970688203321 996 $aPractical process research and development$94340135 997 $aUNINA