LEADER 06376nam a2200493 i 4500 001 991003947819707536 006 m o d 007 cr cnu|||unuuu 008 210624s2018 sz a ob 001 0 eng d 020 $a9783319720418$q(electronic bk.) 020 $a3319720414$q(electronic bk.) 020 $z9783319720401$q(print) 020 $z3319720406 024 7 $a10.1007/978-3-319-72041-8$2doi 035 $ab14413498-39ule_inst 040 $aBibl. Dip.le Aggr. DiSTeBA - Sez. Biologia$beng 082 04$a620.5$223 245 00$aCellular and molecular toxicology of nanoparticles$h[e-book] /$cQuaiser Saquib, Mohammad Faisal, Abdulaziz A. Al-Khedhairy, Abdulrahman A. Alatar, editors 264 1$aCham, Switzerland :$bSpringer,$c2018 300 $a1 online resource (xvi, 346 pages) :$billustrations (some color) 336 $atext$btxt$2rdacontent 337 $acomputer$bc$2rdamedia 338 $aonline resource$bcr$2rdacarrier 490 1 $aAdvances in experimental medicine and biology,$x0065-2598 ;$vvolume 1048 500 $aIncludes index 504 $aIncludes bibliographical references and index 505 0 $aToxicity assessment in the nanoparticle era / Valeria De Matteis, Rosaria Rinaldi -- Mechanisms of uptake and translocation of nanomaterials in the lung / Chloé Puisney, Armelle Baeza-Squiban, Sonja Boland -- Transmucosal nanoparticles: toxicological overview / Swapnil Talkar, Sagar Dhoble, Anuradha Majumdar, Vandana Patravale -- The toxicity of nanoparticles to human endothelial cells / Yi Cao -- The role of autophagy in nanoparticles-induced toxicity and its related cellular and molecular mechanisms / Yubin Li, Dianwen Ju -- Nanoparticles-caused oxidative imbalance / Mariusz Zuberek, Agnieszka Grzelak -- Toxicity of metal oxide nanoparticles / Koyeli Girigoswami -- Relevance of physicochemical characterization of nanomaterials for understanding nano-cellular interactions / Henriqueta Louro -- Toxicogenomics: a new paradigm for nanotoxicity evaluation / Sourabh Dwivedi, Quaiser Saquib, Bilal Ahmad, Sabiha M. Ansari, Ameer Azam, Javed Musarrat -- Nickel oxide nanoparticles induced transcriptomic alterations in HEPG2 cells / Quaiser Saquib, Maqsood A. Siddiqui, Javed Ahmad, Sabiha M. Ansari, Mohammad Faisal, Rizwan Wahab [and others] -- Nanoparticle-protein interaction: the significance and role of protein corona / Saad Mohammad Ahsan, Chintalagiri Mohan Rao, Md. Faiz Ahmad -- Cellular and molecular toxicity of iron oxide nanoparticles / Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Fátima Brandão, João Paulo Teixeira, Eduardo Pásaro [and others] -- Detection of DNA damage induced by cerium dioxide nanoparticles: from models to molecular mechanism activated / Tiago Alves Jorge de Souza, Thiago Lopes Rocha, Leonardo Pereira Franchi -- Mechanisms underlying neurotoxicity of silver nanoparticles / Lidia Stru?y?ska, Joanna Skalska -- Toxic and beneficial potential of silver nanoparticles: the two sides of the same coin / Lilian Rodrigues Rosa Souza, Veronica Santana da Silva, Leonardo Pereira Franchi, Tiago Alves Jorge de Souza -- Molecular and cellular toxicology of nanomaterials with related to aquatic organisms / Mohd Ashraf Rather, Irfan Ahmad Bhat, Niti Sharma, Rupam Sharma -- Cytotoxicity and physiological effects of silver nanoparticles on marine invertebrates / Adriano Magesky, Émilien Pelletier -- A Drosophila model to decipher the toxicity of nanoparticles Taken through oral routes / S. Aurosman Pappus, Monalisa Mishra -- Using of quantum dots in biology and medicine / Svetlana Pleskova, Elza Mikheeva, Ekaterina Gornostaeva 520 $aThis edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called "biomolecular corona". The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers 650 0$aNanoparticles 650 12$aNanoparticles$xtoxicity 650 12$aNanoparticles$xadverse effects 650 22$aToxicity Tests$xmethods 700 1 $aSaquib, Quaiser$eeditor 700 1 $aFaisal, Mohammad$eeditor 700 1 $aAl-Khedhairy, Abdulaziz A.$eeditor 700 1 $aAlatar, Abdulrahman A.$eeditor 776 08$iPrint version:$tCellular and molecular toxicology of nanoparticles.$dCham, Switzerland : Springer, 2018$z3319720406$z9783319720401 830 0$aAdvances in experimental medicine and biology ;$v1048.$x0065-2598 856 40$3SpringerLink$zConnect to resource$uhttp://link.springer.com/10.1007/978-3-319-72041-8 907 $a.b14413498$b03-03-22$c24-06-21 912 $a991003947819707536 996 $aCellular and molecular toxicology of nanoparticles$91807101 997 $aUNISALENTO 998 $ale003$b24-06-21$cm$d@ $e-$feng$gsz $h0$i0