LEADER 00858nam a2200241 i 4500 001 991003709369707536 005 20020509130823.0 008 980715s1962 uk ||| | eng 035 $ab11202828-39ule_inst 035 $aPARLA187090$9ExL 040 $aDip. di Filol. Class. e di Scienze Filosofiche$bita 082 0 $a808.1 100 1 $aHamer, Enid$0191548 245 14$aThe metres of english poetry /$cEnid Hamer 260 $aLondon :$bMethuen & Co. LTD,$c1962 300 $axi, 340 p. ;$c19 cm 650 4$aPoesia inglese - Metrica 907 $a.b11202828$b21-09-06$c01-07-02 912 $a991003709369707536 945 $aLE007 470 HAM 02.01$g1$i2007000038055$lle007$o-$pE0.00$q-$rl$s- $t0$u1$v0$w1$x0$y.i11353661$z01-07-02 996 $aMetres of english poetry$9561885 997 $aUNISALENTO 998 $ale007$b01-01-98$cm$da $e-$feng$guk $h4$i1 LEADER 05574nam 2200733Ia 450 001 9911019353703321 005 20200520144314.0 010 $a9786610519484 010 $a9781280519482 010 $a1280519487 010 $a9783527603756 010 $a3527603751 010 $a9783527603848 010 $a3527603840 035 $a(CKB)1000000000376379 035 $a(EBL)481511 035 $a(OCoLC)69243366 035 $a(SSID)ssj0000211433 035 $a(PQKBManifestationID)11201930 035 $a(PQKBTitleCode)TC0000211433 035 $a(PQKBWorkID)10293010 035 $a(PQKB)11149194 035 $a(MiAaPQ)EBC481511 035 $a(Perlego)2764740 035 $a(EXLCZ)991000000000376379 100 $a20040716d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNitric oxide donors $efor pharmaceutical and biological applications /$fedited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi 210 $aWeinheim ;$a[Great Britain] $cWiley-VCH$dc2005 215 $a1 online resource (414 p.) 300 $aDescription based upon print version of record. 311 08$a9783527310159 311 08$a3527310150 320 $aIncludes bibliographical references and index. 327 $aNitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer 327 $a1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 327 $a2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 327 $a3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 327 $a3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 327 $a4.2.1 Regulation of Blood Flow by HbSNO 330 $aNitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances. 606 $aNitric oxide 606 $aNitric oxide$xPhysiological effect 606 $aDrugs$xDesign 606 $aPharmaceutical chemistry 615 0$aNitric oxide. 615 0$aNitric oxide$xPhysiological effect. 615 0$aDrugs$xDesign. 615 0$aPharmaceutical chemistry. 676 $a572.54 701 $aWang$b Peng George$0738023 701 $aCai$b Tingwai Bill$01837635 701 $aTaniguchi$b Naoyuki$f1942-$01837636 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019353703321 996 $aNitric oxide donors$94416398 997 $aUNINA