LEADER 00938nam a2200265 i 4500 001 991003378239707536 005 20020509121130.0 008 930621s1979 it ||| | grc 035 $ab11152709-39ule_inst 035 $aPARLA180667$9ExL 040 $aDip.to Scienze dell'Antichità$bita 041 0 $agrcita 100 1 $aEuripides$0229973 245 12$aL'Ippolito /$cEuripide ; commento di Antonio Martina 260 $aTorino :$bLoescher,$c1979 300 $aXXVIII, 230 p. ;$c22 cm. 490 0 $aTesti e crestomazie : collana di autori greci e latini 500 $aTesto greco 700 1 $aMartina, Antonio 907 $a.b11152709$b23-02-17$c28-06-02 912 $a991003378239707536 945 $aLE007 880.1 Euripides MAR 01.501$g1$i2015000108364$lle007$o-$pE0.00$q-$rl$s- $t0$u10$v4$w10$x0$y.i11294516$z28-06-02 996 $aIppolito$93041634 997 $aUNISALENTO 998 $ale007$b01-01-93$cm$da $e-$fgrc$git $h2$i1 LEADER 03066nam 2200457z- 450 001 9910346739203321 005 20210211 035 $a(CKB)4920000000094322 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53628 035 $a(oapen)doab53628 035 $a(oapen)53628 035 $a(EXLCZ)994920000000094322 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer 210 $cFrontiers Media SA$d2018 215 $a1 online resource (123 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-389-8 330 $aThe human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a "copy and paste" mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS).To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer. 606 $aChemistry$2bicssc 610 $acellular differentiation 610 $aDNA repair 610 $agenome stability 610 $aMobile DNA 610 $amodel organisms 610 $aretrotransposon 610 $areverse transcriptase 610 $aRNA-dependent DNA polymerase 610 $atransposon 615 7$aChemistry 700 $aJose Luis Garcia Perez$4auth$01325055 702 $aTammy A. Morrish$4auth 906 $aBOOK 912 $a9910346739203321 996 $aMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer$93036524 997 $aUNINA