LEADER 01071nam a22002651i 4500 001 991003307979707536 005 20230322093958.0 008 161124s1992 it b 000 0 ita 020 $a8871443063 035 $ab14313327-39ule_inst 040 $aDip.to di Storia, Società e Studi sull'Uomo$bita 082 0 $a107.1245 100 1 $aCambi, Franco$0144462 245 12$aL'esercizio del pensiero :$binsegnare e apprendere filosofia nella scuola secondaria /$cFranco Cambi 264 4$aRoma :$bArmando,$cc1992 300 $a111 p. ;$c24 cm 490 1 $aProblemi dell'educazione (I). Pratica 650 4$aFilosofia$xInsegnamento$xScuole medie superiori 830 2$aI Problemi dell'educazione.$pPratica 907 $a.b14313327$b16-10-17$c24-11-16 912 $a991003307979707536 945 $aLE023$g1$i2023000145784$lle023$nDATRI/REV/2017$nFondo Angelo Semeraro DR n. 414 del 6/6/2016$og$pE12.00$q-$rn$so$t0$u0$v0$w0$x0$y.i15789664$z28-11-16 996 $aEsercizio del pensiero$93377793 997 $aUNISALENTO 998 $ale023$b24-11-16$cm$da$en$fita$git$h2$i0 LEADER 02778nam 2200421z- 450 001 9910346735003321 005 20210211 035 $a(CKB)4920000000094360 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53425 035 $a(oapen)doab53425 035 $a(EXLCZ)994920000000094360 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMicroglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases 210 $cFrontiers Media SA$d2018 215 $a1 online resource (327 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-525-4 330 $aMicroglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization. 606 $aNeurosciences$2bicssc 610 $aAging 610 $aM1 Microglia 610 $aM1/M2 Switch 610 $aM2 Microglia 610 $aMicroglial Polarization 610 $aNeurodegenerative diseases 610 $aNeuroinflammation 615 7$aNeurosciences 700 $aIsidre Ferrer$4auth$01331919 702 $aYu Tang$4auth 906 $aBOOK 912 $a9910346735003321 996 $aMicroglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases$93040651 997 $aUNINA