LEADER 01225nam a2200301Ii 4500 001 991003271679707536 006 m d 007 cr cn||||||||| 008 070806s2004 ne a sb 001 0 eng d 020 $a9780444515308 020 $a0444515305 035 $ab13658566-39ule_inst 040 $aDip.to Matematica$beng 082 04$a511.5$222 100 1 $aGolumbic, Martin Charles$0104097 245 10$aAlgorithmic graph theory and perfect graphs$h[e-book] /$cMartin Charles Golumbic 260 $aAmsterdam :$bElsevier,$c2004 300 $axxvi, 314 p. :$bill. ;$c25 cm 440 0$aAnnals of discrete mathematics ;$v57 504 $aIncludes bibliographies and index 650 0$aPerfect graphs 856 40$3ScienceDirect$uhttp://www.sciencedirect.com/science/publication?issn=01675060&volume=57$zAn electronic book accessible through the World Wide Web; click for information 856 42$zPublisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0621/2004555477-d.html 907 $a.b13658566$b03-03-22$c29-01-08 912 $a991003271679707536 996 $aAlgorithmic graph theory and perfect graphs$9437139 997 $aUNISALENTO 998 $ale013$b29-01-08$cm$d@ $e-$feng$gne $h0$i0 LEADER 03715nam 22006015 450 001 9910350356103321 005 20251113203406.0 010 $a981-13-8019-8 024 7 $a10.1007/978-981-13-8019-8 035 $a(CKB)4100000008876856 035 $a(DE-He213)978-981-13-8019-8 035 $a(MiAaPQ)EBC5811816 035 $a(PPN)238486885 035 $a(EXLCZ)994100000008876856 100 $a20190702d2019 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHistone Deacetylase Inhibitors ? Epidrugs for Neurological Disorders /$fby Shabir Ahmad Ganai 205 $a1st ed. 2019. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2019. 215 $a1 online resource (XVII, 93 p. 8 illus., 5 illus. in color.) 311 08$a981-13-8018-X 327 $aChapter 1. Role of Epigenetics in neurological diseases -- Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens -- Chapter 3. Distinct classes of HDACs -- Chapter 4. HDAC implications in neurological diseases -- Chapter 5. HDAC inhibitors and their structurally distinct groups -- Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders -- Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies -- Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy -- Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents -- Chapter 10. Future directions of epigenetic research in tackling neurological complications. 330 $aThis book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors? therapeutic efficacy against various neurological complications. 606 $aNeurosciences 606 $aPharmacology 606 $aGenetics 606 $aProteins 606 $aPost-translational modification 606 $aNeuroscience 606 $aPharmacology 606 $aGenetics and Genomics 606 $aProtein Biochemistry 606 $aPost-translational Modifications 615 0$aNeurosciences. 615 0$aPharmacology. 615 0$aGenetics. 615 0$aProteins. 615 0$aPost-translational modification. 615 14$aNeuroscience. 615 24$aPharmacology. 615 24$aGenetics and Genomics. 615 24$aProtein Biochemistry. 615 24$aPost-translational Modifications. 676 $a612.8 700 $aGanai$b Shabir Ahmad$4aut$4http://id.loc.gov/vocabulary/relators/aut$0904016 906 $aBOOK 912 $a9910350356103321 996 $aHistone Deacetylase Inhibitors ? Epidrugs for Neurological Disorders$92020945 997 $aUNINA