LEADER 01787nam--2200481---450- 001 990001934070203316 005 20110831151357.0 035 $a000193407 035 $aUSA01000193407 035 $a(ALEPH)000193407USA01 035 $a000193407 100 $a20040816e19811781km-y0itay50------ba 101 0 $afre 102 $aIT 105 $aa|||||||001yy 200 1 $aVoyage pittoresque, ou Description des royaumes de Naples et de Sicile$f[Saint-Non] 210 $aNapoli$cSocietà editrice napoletana$d1981 215 $a4 v. in 5$cill.$d53 cm 300 $aRipr. facs. dell'ed.: Paris, 1781-1786 300 $aEd. di 500 esempl. num. 517 1 $aDescription des royaumes de Naples et de Sicile 676 $a914.5704 700 1$aSAINT-NON,$bJean Claude Richard : de$0246868 801 0$aIT$bsalbc$gISBD 912 $a990001934070203316 951 $aXII.2.B. 1345/1(I L 157/1)$b2277 L.M.$cXII.2.$d00066849 951 $aXII.2.B. 1345/2(I L 157/2)$b5250 L.M.$cXII.2.$d00066850 951 $aXII.2.B. 1345/3(I L 157/3)$b5251 L.M.$cXII.2.$d00066851 951 $aXII.2.B. 1345/4(I L 157/4)$b5252 L.M.$cXII.2.$d00066852 951 $aXII.2.B. 1345/5(I L 157/5)$b5253 L.M.$cXII.2.$d00066853 959 $aBK 969 $aUMA 969 $aANT 979 $aSIAV2$b10$c20040816$lUSA01$h1543 979 $aCOPAT3$b90$c20050311$lUSA01$h0859 979 $aANNAMARIA$b90$c20080229$lUSA01$h1339 979 $aANNAMARIA$b90$c20080229$lUSA01$h1341 979 $aANNAMARIA$b90$c20080229$lUSA01$h1344 979 $aANNAMARIA$b90$c20080229$lUSA01$h1350 979 $aANNAMARIA$b90$c20080303$lUSA01$h0850 979 $aPATRY$b90$c20110831$lUSA01$h1513 996 $aVoyage pittoresque ou description des Royaumes de Naples et de Sicile$9622595 997 $aUNISA LEADER 03139nam 2200613 450 001 9910465892703321 005 20180731212026.0 035 $a(CKB)3710000000752837 035 $a(EBL)4605128 035 $a(PQKBManifestationID)16513808 035 $a(PQKBWorkID)15043498 035 $a(PQKB)20462487 035 $a(MiAaPQ)EBC4605128 035 $a(DLC) 2016031119 035 $a(EXLCZ)993710000000752837 100 $a20160822h20162016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStudies in lexicogrammar $etheory and applications /$fedited by Grzegorz Drozdz 210 1$aAmsterdam, [Netherlands] ;$aPhiladelphia, [Pennsylvania] :$cJohn Benjamins Publishing Company,$d2016. 210 4$d©2016 215 $a1 online resource (294 p.) 225 1 $aHuman Cognitive Processing,$x1387-6724 ;$vVolume 54 300 $aDescription based upon print version of record. 311 $a90-272-4670-X 311 $a90-272-6666-2 320 $aIncludes bibliographical references and indexes. 327 $a2. Folk theories, expert theories and writing 2.1 Intuitions about linguistic units: Sentences ; 2.2 Intuitions about linguistic units: Phonemes ; 2.3 Intuitions about linguistic units: Words ; 2.4 Grammaticality judgments ; 3. Literary dialogue and intuitions about spoken language ; 4. Coming out of the linguistic closet ; 5. Conclusion ; References ; Virtual lexicogrammar; 1. Setting the scene ; 2. Symbolic semantics in the lexicon-grammar continuum ; 3. The linguistic sign: From semiosis to metonymy ; 4. Virtuality in Langacker ; 5. Virtuality in the history of ideas 327 $a5. Observations and discussion References ; Dictionaries ; What? You and me get together? The place of the Incredulity Response Construction; 1. Introduction ; 2. Differences between lexical and grammatical words ; 2.1 Encyclopedic meanings ; 2.2 Generality ; 2.3 Access to conscious reflection ; 2.4 Construal, non-truth conditionality ; 2.5 Subjectification ; 2.6 Continuum and division ; 3. The Incredulity Response Construction ; 3.1 General characterization ; 3.2 Semantics ; 3.3 Arguments in favor of an iconic binary analysis ; 4. Conclusions ; References 327 $aThe binding hierarchy and infinitival complementation in English and in Polish 410 0$aHuman cognitive processing ;$vVolume 54. 606 $aLexical grammar 606 $aGrammar, Comparative and general$xSyntax 606 $aGrammar, Comparative and general$xMorphology 606 $aConstruction grammar 606 $aPsycholinguistics 608 $aElectronic books. 615 0$aLexical grammar. 615 0$aGrammar, Comparative and general$xSyntax. 615 0$aGrammar, Comparative and general$xMorphology. 615 0$aConstruction grammar. 615 0$aPsycholinguistics. 676 $a415.01/835 702 $aDroz?dz?$b Grzegorz 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910465892703321 996 $aStudies in lexicogrammar$92073501 997 $aUNINA LEADER 01116nam a2200277 i 4500 001 991001538559707536 005 20020502200253.0 008 930705s1987 ||| ||| | ita 020 $a8839704485 035 $ab11527559-39ule_inst 035 $aPRUMB63015$9ExL 040 $aScuola per assistenti sociali$bita 100 1 $aCantor, Muriel G.$0142065 245 10$aSoap Opera :$bproduzione, contenuti e pubblico di un genere televisivo /$cMuriel G. Cantor, Suzanne Pingree ; traduzione e introduzione di Enzo Cappelli 260 $aTorino :$bEri,$cc1987 300 $a135 p. :$btab. ;$c21 cm. 440 3$aLe comunicazioni di massa ;$v35 650 4$aComunicazioni di massa 700 1 $aPingree, Suzanne$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0735007 700 1 $aCappelli, Enzo 907 $a.b11527559$b12-10-12$c01-07-02 912 $a991001538559707536 945 $aLE024 SOC COM II 42$g1$iLE024N-2375$lle021$nex DUSS$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i11724110$z01-07-02 996 $aSoap opera$91451768 997 $aUNISALENTO 998 $ale021$b01-01-93$cm$da $e-$feng$gxx $h0$i1 LEADER 05192nam 2200625 450 001 9910830717703321 005 20230721033137.0 010 $a1-281-94698-2 010 $a9786611946982 010 $a3-527-62267-5 010 $a3-527-62268-3 035 $a(CKB)1000000000551934 035 $a(EBL)481533 035 $a(OCoLC)277153234 035 $a(SSID)ssj0000112294 035 $a(PQKBManifestationID)11142796 035 $a(PQKBTitleCode)TC0000112294 035 $a(PQKBWorkID)10086817 035 $a(PQKB)10524340 035 $a(MiAaPQ)EBC481533 035 $a(EXLCZ)991000000000551934 100 $a20160819h20082008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiosimulation in drug development /$fedited by Martin Bertau, Erik Mosekilde, and Hans V. 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KGaA,$d2008. 210 4$d©2008 215 $a1 online resource (542 p.) 300 $aIncludes index. 311 $a3-527-31699-X 327 $aBiosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction 327 $a2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic ?-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 327 $a3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 327 $a3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 327 $a4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 327 $a5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling 330 $aThis first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. 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