LEADER 01118nam a2200277 i 4500 001 991002745149707536 005 20020508205311.0 008 960614s1964 it ||| | ita 035 $ab11054256-39ule_inst 035 $aPARLA168178$9ExL 040 $aDip.to scienze storiche$bita 100 1 $aGreenfield, Kent Roberts$0137231 245 10$aEconomia e liberalismo nel Risorgimento :$bil movimento nazionale in Lombardia dal 1814 al 1848 /$cKent roberts Greenfield ; saggio introduttivo di Rosario Romeo 260 $aBari :$bLaterza,$c1964 300 $aVI, 458 p. ;$c21 cm. 490 0 $aCollezione storica - Laterza 650 4$aLiberalismo 650 4$aLombardia - Movimento nazionale$y1814-1848 650 4$aRisorgimento italiano$xEconomia 700 1 $aRomeo, Rosario 907 $a.b11054256$b23-02-17$c28-06-02 912 $a991002745149707536 945 $aLE009 STOR. 63-123$g1$i2009000186576$lle009$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i11179326$z28-06-02 996 $aEconomia e liberalismo nel Risorgimento$9133698 997 $aUNISALENTO 998 $ale009$b01-01-96$cm$da $e-$fita$git $h0$i1 LEADER 03680nam 2200517 450 001 9910583398303321 005 20210201183319.0 010 $a0-12-814190-5 035 $a(CKB)4100000005879636 035 $a(MiAaPQ)EBC5495415 035 $a(EXLCZ)994100000005879636 100 $a20180904h20182018 uy| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 181 $csti$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNoninvasive prenatal testing (NIPT)$b[electronic resource] $eapplied genomics in prenatal screening and diagnosis /$fedited by Lieve Page-Christiaens, Hanns-Georg Klein 210 1$aLondon :$cAcademic Press,$d[2018] 210 4$dİ2018 215 $a1 online resource (xxvii, 377 pages) $cillustrations 311 $a0-12-814189-1 320 $aIncludes bibliographical references and index. 327 $aSection 1: Cell-freeDNA (CfDNA): overview and technology. Fetal DNA in maternal plasma: an amazing two decades -- Understanding the basics of next generation sequencing in the context of cell-free DNA based NIPT -- The technology and bioinformatics of cell-free DNA based NIPT -- Section 2: CfDNA in clinical practice. Prenatal screening for common aneuploidies before and after the introduction of cell-free DNA based NIPT -- Why cell-free DNA based NIPT for fetal chromosome anomalies is not diagnostic -- The role of cell-free DNA based NIPT in twin pregnancy -- Genomewide testing for autosomal trisomies and copy number variations -- Non-invasive fetal blood group typing -- Noninvasive prenatal diagnosis (NIPD) of monogenic disorders -- Maternal constitutional and acquired copy number variations (CNVs) -- Section 3: Clinical integration. Best practices for integrating cell-free DNA based NIPT into clinical practice -- Quality assurance and standardization of cell-free DNA based NIPT laboratory procedures -- Decisional support for expectant parents -- Cell-free DNA based NIPT and society -- Ethics of cell-free DNA based NIPT for sex chromosome aneuploidies and sex determination -- Cost-effectiveness of cell-free DNA based NIPT: summary of evidence and challenges -- Section 4: The future. Exome sequencing in the evaluation of the fetus with structural anomalies -- Cell-based NIPT: a promising path for prenatal diagnosis -- Maternal circulating nucleic acids as a marker of placental health -- Prenatal treatment of genetic diseases in the unborn 330 $a"Since its introduction in 2012, cell-free (cf) DNA based Non-Invasive Prenatal Testing (NIPT) has been employed to test for fetal chromosome abnormalities, and gene mutations that lead to a variety of genetic conditions, by millions of pregnant women, in more than 90 countries worldwide. With Noninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and Diagnosis, Dr Lieve Page-Christiaens and Dr Hanns-Georg Klein have compiled the first authoritative volume on cfDNA NIPT methods and their clinical implementation"--Publisher's description. 606 $aPrenatal diagnosis 606 $aDiagnosis, Noninvasive 606 $aGenetic Testing 606 $aPrenatal Diagnosis 606 $aDNA$xblood 615 0$aPrenatal diagnosis. 615 0$aDiagnosis, Noninvasive. 615 12$aGenetic Testing. 615 22$aPrenatal Diagnosis. 615 22$aDNA$xblood. 676 $a52 702 $aPage-Christiaens$b Lieve 702 $aKlein$b Hanns-Georg 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583398303321 996 $aNoninvasive prenatal testing (NIPT)$91916106 997 $aUNINA