LEADER 01518nam 2200433 450 001 9910324047503321 005 20220930155139.0 010 $a0-88099-433-9 035 $a(CKB)3780000000104759 035 $a(NjHacI)993780000000104759 035 $a(EXLCZ)993780000000104759 100 $a20220930d2009 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSustainable Prosperity in the New Economy? $eBusiness Organization and High-Tech Employment in the United States /$fWilliam Lazonick 210 1$aKalamazoo, Michigan :$cW.E. Upjohn Institute,$d2009. 215 $a1 online resource (xviii, 357 pages) $cillustrations 311 $a0-88099-350-2 320 $aIncludes bibliographical references and index. 517 $aSustainable Prosperity in the New Economy? 606 $aInformation technology$xEconomic aspects$zUnited States 606 $aHigh technology industries$zUnited States 606 $aLabor market$zUnited States 606 $aEconomic development$zUnited States 615 0$aInformation technology$xEconomic aspects 615 0$aHigh technology industries 615 0$aLabor market 615 0$aEconomic development 676 $a330.973 700 $aLazonick$b William$0119552 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910324047503321 996 $aSustainable Prosperity in the New Economy$92948370 997 $aUNINA LEADER 01080nam a2200265 i 4500 001 991002703149707536 005 20020508204605.0 008 980219s1983 it ||| | ita 035 $ab1104794x-39ule_inst 035 $aPARLA167463$9ExL 040 $aDip.to Scienze dell'Antichità$bita 082 0 $a301.412 100 1 $aSavalli, Ivana$0311161 245 13$aLa donna nella societa della Grecia antica /$cIvana Savalli 260 $aBologna :$bPatron,$c1983 300 $a276 p. ;$c24 cm 500 $aCon una raccolta di testi 650 4$aDonna$xPosizione sociale$zGrecia antica$xAntologie 907 $a.b1104794x$b17-02-17$c28-06-02 912 $a991002703149707536 945 $aLE015 938 - 100$g1$i2015000009197$lle007$o-$pE0.00$q-$rl$s- $t0$u15$v3$w15$x0$y.i11172344$z28-06-02 945 $aLE007 Sala C 938 SAV01.01 $g1$i2007000279076$lle007$nLE007 2017 Pregresso$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i15797545$z17-02-17 996 $aDonna nella società della Grecia antica$9715382 997 $aUNISALENTO 998 $ale007$b01-01-98$cm$da $e-$fita$git $h3$i1 LEADER 04645nam 2201093z- 450 001 9910595072803321 005 20220916 035 $a(CKB)5680000000080798 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/92142 035 $a(oapen)doab92142 035 $a(EXLCZ)995680000000080798 100 $a20202209d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBioprocess Systems Engineering Applications in Pharmaceutical Manufacturing 210 $aBasel$d2022 215 $a1 online resource (226 p.) 311 08$a3-0365-5210-3 311 08$a3-0365-5209-X 330 $aBiopharmaceutical and pharmaceutical manufacturing are strongly influenced by the process analytical technology initiative (PAT) and quality by design (QbD) methodologies, which are designed to enhance the understanding of more integrated processes. The major aim of this effort can be summarized as developing a mechanistic understanding of a wide range of process steps, including the development of technologies to perform online measurements and real-time control and optimization. Furthermore, minimization of the number of empirical experiments and the model-assisted exploration of the process design space are targeted. Even if tremendous progress has been achieved so far, there is still work to be carried out in order to realize the full potential of the process systems engineering toolbox. Within this reprint, an overview of cutting-edge developments of process systems engineering for biopharmaceutical and pharmaceutical manufacturing processes is given, including model-based process design, Digital Twins, computer-aided process understanding, process development and optimization, and monitoring and control of bioprocesses. The biopharmaceutical processes addressed focus on the manufacturing of biopharmaceuticals, mainly by Chinese hamster ovary (CHO) cells, as well as adeno-associated virus production and generation of cell spheroids for cell therapies. 606 $aHistory of engineering and technology$2bicssc 606 $aTechnology: general issues$2bicssc 610 $aAdeno-associated virus 610 $aBayes optimization 610 $abiopharmaceutical manufacturing 610 $abioprocess 610 $abioreactor 610 $abioreactor characterization 610 $abiosensor 610 $abiotherapeutics production 610 $acell culture 610 $acell culture model 610 $aChinese hamster ovary cells 610 $aCHO DP-12 610 $aclonal cell population 610 $acomputational fluid dynamics 610 $acontinuous 610 $acritical shear stress 610 $acryopreservation 610 $adiabetes 610 $aEscherichia coli 610 $aGaussian processes 610 $agene therapy 610 $ahybrid modeling 610 $ahydrodynamic gradients 610 $ahydrodynamic stress 610 $ainoculum train 610 $aKolmogorov length scale 610 $amachine learning 610 $amicrocarriers 610 $amodel-assisted DoE 610 $amonitoring 610 $amonoclonal antibodies 610 $amulti-objective 610 $an/a 610 $aN?1 perfusion 610 $aoperational space 610 $aPareto optimization 610 $aPAT 610 $aPEI 610 $aphenotypic diversity 610 $aprocess analytical technology (PAT) 610 $aprocess development 610 $aprocess intensification 610 $aquality by design 610 $aquality by design (QbD) 610 $aseed train 610 $asensors 610 $ashear stress-guided production 610 $asmart biomanufacturing 610 $asoft-sensor 610 $aspectroscopy 610 $aspheroid strength 610 $asurface plasmon resonance (SPR) 610 $atransfection 610 $atransient expression 610 $auncertainty-based 610 $aupstream bioprocessing 610 $aupstream processing 610 $avaccines production 610 $a?-cells 615 7$aHistory of engineering and technology 615 7$aTechnology: general issues 700 $aPo?rtner$b Ralf$4edt$01207271 702 $aMo?ller$b Johannes$4edt 702 $aPo?rtner$b Ralf$4oth 702 $aMo?ller$b Johannes$4oth 906 $aBOOK 912 $a9910595072803321 996 $aBioprocess Systems Engineering Applications in Pharmaceutical Manufacturing$93033986 997 $aUNINA