LEADER 01007nam0-22003011i-450 001 990001723540403321 005 20190730102540.0 010 $a88-7064-141-4 035 $a000172354 035 $aFED01000172354 035 $a(Aleph)000172354FED01 035 $a000172354 100 $a20030910d1987----km-y0itay50------ba 101 0 $aita 200 1 $aUrbanistica rurale$eatti dei seminari integrativi del corso di urbanistica rurale$fcoordinatore Alessandro Toccolini$gUniversità degli Studi di Milano. Istituto di Ingegneria Agraria 210 $aMilano$cCLESAV$d1987 215 $a202 p.$d24 cm 610 0 $aUrbanistica rurale 676 $a711.554 702 1$aToccolini,$bAlessandro$f<1949- > 710 02$aUniversità degli studi di Milano.$bIstituto di ingegneria agraria$0355256 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990001723540403321 952 $a60 711.554 TOCA 1987$b933$fFAGBC 959 $aFAGBC 996 $aUrbanistica rurale$9360547 997 $aUNINA LEADER 01205nam a2200301 i 4500 001 991002636379707536 005 20020508203542.0 008 971113s1968 uk ||| | grc 020 $a0198145667 035 $ab11038810-39ule_inst 035 $aPARLA166355$9ExL 040 $aDip.to Scienze dell'Antichità$bita 041 0 $agrclat 100 1 $aLonginus$0330739 245 10$aDionysio Longino fere adscriptus Libellus de sublimitate /$crecognovit brevique adnotatione critica instruxit D. A. Russell 260 $aOxonii :$bE Typographeo Clarendoniano,$cMCMLXVIII (1968) 300 $aVIII, 94 p. ;$c20 cm. 490 0 $aScriptorum classicorum bibliotheca Oxoniensis 500 $aIndici. 500 $aTesto in Greco antico, introduzione e note in Latino. 650 4$aPseudo-Longino 700 1 $aRussell, Donald Andrew 907 $a.b11038810$b23-02-17$c28-06-02 912 $a991002636379707536 945 $aLE015 BIBL. OXON. PSEUDO-LONGINUS 1$g1$i2015000004918$lle007$o-$pE0.00$q-$rn$so $t0$u0$v0$w0$x0$y.i11161334$z28-06-02 996 $aDionysio Longino fere adscriptus Libellus de sublimitate$9858840 997 $aUNISALENTO 998 $ale007$b01-01-97$cm$da $e-$fgrc$guk $h0$i1 LEADER 04944nam 22005535 450 001 9910253895003321 005 20250609111212.0 010 $a3-319-33826-9 024 7 $a10.1007/978-3-319-33826-2 035 $a(CKB)3710000000873117 035 $a(DE-He213)978-3-319-33826-2 035 $a(MiAaPQ)EBC4697485 035 $a(PPN)195507665 035 $a(MiAaPQ)EBC6235585 035 $a(EXLCZ)993710000000873117 100 $a20160926d2016 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aValidation of Alternative Methods for Toxicity Testing /$fedited by Chantra Eskes, Maurice Whelan 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XX, 407 p. 44 illus., 40 illus. in color.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v856 311 08$aPrint version: Validation of alternative methods for toxicity testing. [Cham, Switzerland] : Springer, c2016 xx, 407 pages Advances in experimental medicine and biology ; Volume 856. 9783319338248 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- Validation in support of internationally harmonised OECD Test Guidelines for assessing the safety of chemicals -- Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals -- Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools -- Practical aspects of designing and conducting validation studies involving multi-study trials -- Validation of computational methods -- Implementation of New Test Methods into Practical Testing -- Pathway Based Toxicology and Fit-for-Purpose Assays -- Evidence-based toxicology -- Validation of transcriptomics-based in vitro methods -- Ensuring the quality of stem cell-derived in vitro models for toxicity testing -- Validation of bioreactor and human-on-a-chip devices for chemical safety assessment -- Integrated approaches to testing and assessment -- International harmonization and cooperation in the validation of alternative methods -- Evolving the principles and practice of validation for new alternative approaches to toxicity testing. . 330 $aThis book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing. . 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v856 606 $aPharmaceutical technology 606 $aMolecular biology 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aPharmaceutical technology. 615 0$aMolecular biology. 615 14$aPharmaceutical Sciences/Technology. 615 24$aMolecular Medicine. 676 $a615.704028 702 $aEskes$b Chantra$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWhelan$b Maurice$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910253895003321 996 $aValidation of Alternative Methods for Toxicity Testing$92527120 997 $aUNINA