LEADER 01067cam a2200265 a 4500 001 991002128009707536 008 040130s20032003enkaaa b 001 0 eng 020 $a0521528844 035 $ab13480042-39ule_inst 040 $aDip.to Beni Culturali$bita 100 1 $aHodder, Ian$0207943 245 10$aReading the past :$bcurrent approaches to interpretation in archaeology /$cIan Hodder and Scott Hutson 246 $a3. ed. 260 $aCambridge ;$aNew York :$bCambridge University Press,$c2003 300 $aXVIII, 293 p. :$bill. ;$c22 cm. 504 $aContiene bibliografia: pp. 248-283 650 4$aArcheologia$xFilosofia 650 0$aArcheologia$xMetodologia 700 1 $aHutson, Scott$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0738541 907 $a.b13480042$b27-06-07$c13-02-07 912 $a991002128009707536 945 $aLE001 AR I 42 8°$g1$i2001000160617$lle001$op$pE22.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i14365844$z13-02-07 996 $aReading the past$91462807 997 $aUNISALENTO 998 $ale001$b13-02-07$cm$da $e-$feng$genk$h0$i0 LEADER 04598nam 2200421z- 450 001 9910220057803321 005 20210211 035 $a(CKB)3800000000216200 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42240 035 $a(oapen)doab42240 035 $a(EXLCZ)993800000000216200 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiology of Cognitive Aging: Model Systems, Technologies and Beyond 210 $cFrontiers Media SA$d2017 215 $a1 online resource (145 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-144-5 330 $aWelcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer's disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves "old" memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer's disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves "old" memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D. 517 $aBiology of Cognitive Aging 606 $aGenetics (non-medical)$2bicssc 610 $aage-related memory impairment 610 $aAlzheimer's disease 610 $aDementia 610 $aoutreach 610 $aParkinson's disease 610 $aPatients 610 $aSemi-automated system 615 7$aGenetics (non-medical) 700 $aShin Murakami$4auth$01287787 906 $aBOOK 912 $a9910220057803321 996 $aBiology of Cognitive Aging: Model Systems, Technologies and Beyond$93020389 997 $aUNINA