LEADER 05117nam 2200649 450 001 996197616603316 005 20230421044511.0 010 $a1-281-84268-0 010 $a9786611842680 010 $a3-527-61503-2 010 $a3-527-61502-4 035 $a(CKB)1000000000376033 035 $a(EBL)482162 035 $a(OCoLC)289312334 035 $a(SSID)ssj0000229621 035 $a(PQKBManifestationID)12085625 035 $a(PQKBTitleCode)TC0000229621 035 $a(PQKBWorkID)10171954 035 $a(PQKB)10100975 035 $a(MiAaPQ)EBC482162 035 $a(EXLCZ)991000000000376033 100 $a20160819h19961996 uy 0 101 0 $ager 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProtein phosphorylation /$fedited by F. Marks 210 1$aWeinheim, [Germany] :$cVCH,$d1996. 210 4$dİ1996 215 $a1 online resource (409 p.) 300 $aDescription based upon print version of record. 311 $a3-527-29241-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aProtein Phosphorylation; Preface; Contents; List of contributors; List of Abbreviations; 1 The brain of the cell; 1.1 Signals and symbols; 1.2 Proteins as communicative molecules; 1.3 The discovery of protein phosphorylation; 1.4 Protein phosphorylation in prokaryotes; 1.5 Protein phosphorylation in eukaryotes; 1.5.1 Eukaryotic protein kinases: common features and diversities; 1.5.2 Control of protein kinase activity; 1.5.3 The problem of substrate specificity; 1.5.4 Regulatory signals for protein kinases and examples of signaling cross-talk 327 $a1.5.5 Protein tyrosine phosphorylation and the integrity of multicellular organisms1.6 Signal extinction by protein dephosphorylation; 1.7 Cancer: a cellular 'psychosis'; 1.8 Advancing beyond the metaphor: proteins as non-trivial machines; References; 2 cAMP-dependent protein kinase: structure, function and control; 2.1 Introduction; 2.2 Biochemistry of cAPK; 2.2.1 Principles of purification of cAPK; 2.2.2 The catalytic subunit (C-subunit); 2.2.3 Control of cAPK; 2.3 Cellular aspects of cAPK function and control; 2.3.1 In vivo control of cAPK; 2.3.2 Cellular location of cAPK subunits 327 $a2.4 Structural aspects of cAPK function2.4.1 Dynamics of substrate-induced fit in solution; 2.4.2 Crystal structure of cAPK C-subunit; 2.4.3 Aspects of future research on cAPK; 2.5 A quick look at the cGMP-dependent protein kinase: a close relative of cAPK; 2.6 Structural consequences of protein phosphorylation in general; 2.6.1 Immediate physical consequences; 2.6.2 Conformational change - indirect evidence; 2.6.3 Conformational change - direct evidence; 2.6.4 Structural effects in peptides; References; 3 Protein kinase C; 3.1 Introduction; 3.2 The protein kinase C isoenzyme family 327 $a3.2.1 The PKC subfamilies3.2.2 PKC isoenzyme structures: common features and differences3; 3.2.3 Regulation of PKC activity4; 3.3 Cellular functions of protein kinase C; 3.3.1 Activators and inhibitors as tools in PKC research; 3.3.2 Phorbol ester effects; 3.3.3 Are effects of phorbol esters and DAG reliable indicators of PKC action?; 3.3.4 Effects of altered PKC expression on cellular functions; 3.3.5 PKC substrates11; 3.3.6 How PKC may acquire substrate specificity; 3.4 Protein kinase C in disease; 3.4.1 Involvement of PKC expression in benign and malignant hyperproliferative diseases 327 $a3.4.2 Oncogenic and anti-oncogenic effects of protein kinase C expression3.4.3 Protein kinase C and skin tumor promotion; References; 4 Casein kinases; 4.1 The different classes of casein kinases; 4.2 Protein kinase CK2; 4.2.1 History; 4.2.2 Biochemical features; 4.2.3 Molecular structures. interaction of subunits and regulation mechanisms; 4.2.4 CK2 genes and their chromosomal locations; 4.2.5 Transcribed CK2 messages and transcription control; 4.2.6 Cell physiological roles of CK2; 4.2.7 CK2 in mitogenic signal transmission; 4.2.8 CK2 and the cell cycle; 4.3 Protein kinase CK1 327 $a4.3.1 Biochemical features and molecular structures of CK1 330 $aProtein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature. 606 $aPhosphoproteins$xSynthesis 606 $aPhosphoproteins$xMetabolism 606 $aProtein kinases 615 0$aPhosphoproteins$xSynthesis. 615 0$aPhosphoproteins$xMetabolism. 615 0$aProtein kinases. 676 $a572.65 676 $a574.19245 702 $aMarks$b Friedrich$f1936- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996197616603316 996 $aProtein phosphorylation$983639 997 $aUNISA LEADER 01088nam a2200289 i 4500 001 991002101529707536 005 20020508190511.0 008 980424s1988 ||| ||| | eng 020 $a9004085009 035 $ab10959440-39ule_inst 035 $aPARLA154543$9ExL 040 $aDip.to Filosofia$bita 082 0 $a181.5 100 1 $aGutas, Dimitri$0157239 245 10$aAvicenna and the Aristotelian tradition :$bintroduction to reading Avicenna's philosophical works /$cby Dimitri Gutas 260 $aLeiden ; New York :$bE.J. Brill,$c1988 300 $axii, 341 p. ;$c25 cm. 490 0 $aIslamic philosophy and theology ;$vv. 4 500 $aIncludes bibliographical references and indexes. 600 04$aAvicenna 650 4$aAristotele 907 $a.b10959440$b23-02-17$c28-06-02 912 $a991002101529707536 945 $aLE005 Ist.Fil. LIV F 4$g1$i2005000018787$lle005$o-$pE0.00$q-$rl$s- $t0$u2$v3$w2$x0$y.i11068401$z28-06-02 996 $aAvicenna and the Aristotelian tradition$925604 997 $aUNISALENTO 998 $ale005$b01-01-98$cm$da $e-$feng$gxx $h0$i1