LEADER 01059nam a2200313 i 4500 001 991002050779707536 005 20020508185629.0 008 000315s1982 it ||| | ita 035 $ab10951829-39ule_inst 035 $aPARLA153602$9ExL 040 $aDip.to Scienze Storiche Fil. e Geogr.$bita 082 0 $a540.1 100 1 $aEliade, Mircea$0127461 245 10$aArti del metallo e alchimia /$cMircea Eliade 250 $aristampa 260 $aTorino :$bBoringhieri,$c1982 300 $a189 p. ;$c22 cm. 490 0 $aSaggi [Boringhieri] 500 $aTit.orig.: Forgerons et alchimistes. 500 $aTrad. di Francesco Sircana. 650 4$aAlchimia 700 1 $aSircana, Francesco 740 0 $aForgerons et alchimistes 907 $a.b10951829$b23-02-17$c28-06-02 912 $a991002050779707536 945 $aLE009 STOR.98-45$g1$i2009000141827$lle009$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i11059527$z28-06-02 996 $aForgerons et alchimistes$922782 997 $aUNISALENTO 998 $ale009$b01-01-00$cm$da $e-$fita$git $h0$i1 LEADER 04354nam 22007815 450 001 9910298288303321 005 20251116135925.0 010 $a3-662-44287-6 024 7 $a10.1007/978-3-662-44287-6 035 $a(CKB)3710000000305964 035 $a(EBL)1965953 035 $a(SSID)ssj0001385831 035 $a(PQKBManifestationID)11746770 035 $a(PQKBTitleCode)TC0001385831 035 $a(PQKBWorkID)11358697 035 $a(PQKB)11646825 035 $a(DE-He213)978-3-662-44287-6 035 $a(MiAaPQ)EBC1965953 035 $a(PPN)183087925 035 $a(EXLCZ)993710000000305964 100 $a20141129d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGenetics of the Mouse /$fby Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli 205 $a1st ed. 2015. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2015. 215 $a1 online resource (417 p.) 300 $aDescription based upon print version of record. 311 08$a3-662-44286-8 320 $aIncludes bibliographical references. 327 $aOrigins of the Laboratory Mouse -- Basic Concepts of Reproductive Biology And Genetics -- Cytogenetics -- Gene Mapping -- The Mouse Genome -- Epigenetic Control of Genome Expression -- Mutations and Experimental Mutagenesis -- Transgenesis and Transgenic Animals -- The Different Categories of Genetically Standardized Populations of Laboratory Mice -- Quantitative Traits and Quantitative Genetics. 330 $aThis book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.   The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.   In short, this book offers an essential resource for all scientists who use or plan to use mice in their research. 606 $aAnimal genetics 606 $aAnimal models in research 606 $aTransgenic organisms 606 $aGene expression 606 $aGenetic engineering 606 $aAnimal Genetics and Genomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L32030 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 606 $aTransgenics$3https://scigraph.springernature.com/ontologies/product-market-codes/L25025 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aGenetic Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/C12037 615 0$aAnimal genetics. 615 0$aAnimal models in research. 615 0$aTransgenic organisms. 615 0$aGene expression. 615 0$aGenetic engineering. 615 14$aAnimal Genetics and Genomics. 615 24$aAnimal Models. 615 24$aTransgenics. 615 24$aGene Expression. 615 24$aGenetic Engineering. 676 $a570 676 $a591.35 676 $a611.01816 676 $a616.027 676 $a660.65 700 $aGue?net$b Jean Louis$4aut$4http://id.loc.gov/vocabulary/relators/aut$01058334 702 $aBenavides$b Fernando$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aPanthier$b Jean-Jacques$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aMontagutelli$b Xavier$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298288303321 996 $aGenetics of the Mouse$92499289 997 $aUNINA