LEADER 01450nam a2200277 i 4500 001 991002039319707536 008 120629s2012 it b 000 0 ita d 020 $a9788834828021 035 $ab14111160-39ule_inst 040 $aDip.to Scienze dell'economia$bita 082 04$a332.362 245 00$aStrumenti e prodotti finanziari :$bbisogni di investimento, finanziamento, pagamento e gestione dei rischi /$cAndrea Ferrari ... [et al.] 260 $aTorino :$bGiappichelli ,$cc2012 300 $aviii, 241 p. ;$c24 cm 504 $aBibliografia: p. [239]-241 650 04$aMercati finanziari$xRischi$xGestione 650 04$aInvestimenti 700 1 $aFerrari, Andrea$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0460599 907 $a.b14111160$b28-01-14$c29-04-13 912 $a991002039319707536 945 $aLE025 ECO 332.6 FER01.02$g1$i2025000263321$lle025$nLibro di testo prof.ssa Cosma a.a. 2012/2013$o-$pE22.00$q-$rl$s- $t16$u0$v0$w0$x0$y.i15514407$z03-06-13 945 $aLE025 ECO 332.6 FER01.02$g2$i2025000263338$lle025$nLibro di testo prof.ssa Cosma a.a. 2012/2013$o-$pE22.00$q-$rl$s- $t16$u0$v0$w0$x0$y.i15514419$z03-06-13 945 $aLE025 ECO 332.6 FER01.02$g3$i2025000263345$lle025$nLibro di testo prof.ssa Cosma a.a. 2012/2013$o-$pE22.00$q-$rl$s- $t0$u25$v7$w25$x0$y.i15514432$z03-06-13 996 $aStrumenti e prodotti finanziari$91442932 997 $aUNISALENTO 998 $ale025$b29-04-13$cc$da $e-$fita$git $h0$i0 LEADER 04023nam 2200589Ia 450 001 9910739430703321 005 20200520144314.0 010 $a1-4614-6528-1 024 7 $a10.1007/978-1-4614-6528-7 035 $a(CKB)2550000001043798 035 $a(EBL)1205328 035 $a(SSID)ssj0000880124 035 $a(PQKBManifestationID)11484962 035 $a(PQKBTitleCode)TC0000880124 035 $a(PQKBWorkID)10872091 035 $a(PQKB)10872303 035 $a(DE-He213)978-1-4614-6528-7 035 $a(MiAaPQ)EBC1205328 035 $a(PPN)169136345 035 $a(Au-PeEL)EBL1205328 035 $a(CaPaEBR)ebr10685059 035 $a(OCoLC)838389037 035 $a(EXLCZ)992550000001043798 100 $a20130219d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVesicle trafficking in cancer /$fYosef Yarden, Gabi Tarcic, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (393 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-9496-3 311 $a1-4614-6527-3 327 $aPreface -- Clathrin Mediated Endocytosis -- Intimate And Facultative? Regulation Of Clathrin-Mediated Endocytosis By The Actin Cytoskeleton -- Oncogenic Signaling From The Plasma Membrane -- Endocytosis In The Spatial Control Of Polarized Cell Functions -- Aberrant Vesicular Trafficking Contributes To Altered Polarity And Metabolism In Cancer -- Endocytosis And The Regulation Of Cell Signaling, Cell Adhesion, And Epithelial To Mesenchymal Transition In Cancer -- Efficient Enhancement Of Signaling Capacity: Signaling Endosomes -- Nuclear Functions And Trafficking Of Receptor Tyrosine Kinases -- Efficient Enhancement Of Signaling Capacity ? The Ubiquitin System.-  Molecular Mechanism Of Ubiquitin-Dependent Traffic -- Cbl As A Master Regulator Of Receptor Tyrosine Kinase Trafficking -- Regulation Of Endocytic Trafficking And Signaling By Deubiquitylating Enzymes -- RTKs As Models For Trafficking Regulation - C-Met/HGF-Receptor- C-Met Signalling In Cancer: Location Counts -- Regulation Of Epidermal Growth Factor Receptor Signaling By Endocytosis In Normal And Malignant Cells -- Stress-Driven Endocytosis Of Tyrosine-Phosphorylated EGFR Leads To Tumorigenesis: The Critical Role Of Oxidative Stress -- Internalisation, Endosomal Trafficking And Recycling Of Integrins During Cell Migration And Cancer Invasion -- Antibody-mediated receptor endocytosis: Harnessing the cellular machinery to combat cancer -- Index. 330 $aEndocytosis and vesicular trafficking determine the landscape of the cell?s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer. 606 $aEndocytosis 606 $aCoated vesicles 615 0$aEndocytosis. 615 0$aCoated vesicles. 676 $a616.99 676 $a616.99/4 676 $a616.994071 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739430703321 996 $aVesicle Trafficking in Cancer$93553810 997 $aUNINA