LEADER 01221cam0-2200349---450- 001 990009404320403321 005 20130404131810.0 010 $a978-88-492-2083-4 035 $a000940432 035 $aFED01000940432 035 $a(Aleph)000940432FED01 035 $a000940432 100 $a20110725d2010----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $aa-------001yy 200 1 $aAlle radici dell'identità nazionale$eItalia nazione culturale$e[Roma, Complesso del Vittoriano Scalee - Sala Zanardelli, 17 marzo - 2 giugno 2011]$fmostra a cura di Marcello Veneziani 210 $aRoma$cGangemi$d2010 215 $a287 p.$cill.$d30 cm 300 $aCatalogo della Mostra tenuta a Roma nel 2011 300 $aIn testa al front.: Roma capitale ; 1861-2011, 150. anniversario Unità d'Italia 610 0 $aItalia$aNazionalità$aDocumenti$aEsposizioni$a2011 676 $a945$v21$zita 700 1$aVeneziani,$bMarcello$0176643 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a990009404320403321 952 $aII F 268$b46757$fFSPBC 952 $aXXXI Varie 433$b48869$fFSPBC 959 $aFSPBC 996 $aAlle radici dell'identità nazionale$9764669 997 $aUNINA LEADER 03404oam 2200469I 450 001 9910493199603321 005 20190411220354.0 010 $a90-474-2613-4 024 7 $a10.1163/9789047426134 035 $a(CKB)3710000000754727 035 $a(EBL)4620868 035 $a(PQKBManifestationID)16495304 035 $a(PQKBWorkID)15026548 035 $a(PQKB)23458276 035 $a(MiAaPQ)EBC4620868 035 $a(nllekb)BRILL9789047426134 035 $a(EXLCZ)993710000000754727 100 $a20160620d2016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNon-native species and their role in the environment $ethe need for a broader perspective /$fby Radu Cornel Guias?u 210 1$aBoston :$cBrill,$d2016. 215 $a1 online resource (328 p.) 300 $aDescription based upon print version of record. 311 $a90-04-17266-1 320 $aIncludes bibliographical references and index. 327 $tPreliminary Material /$rRadu Cornel Guia?u -- $tIntroduction /$rRadu Cornel Guia?u -- $tThe Troublesome Matter of Subjective Definitions /$rRadu Cornel Guia?u -- $tThe Dynamic Distributions of Species and the Static Concept of Native Range /$rRadu Cornel Guia?u -- $tSpeciation, Biodiversity, and Introduced Species /$rRadu Cornel Guia?u -- $tThe Controversies Regarding the Perceived Negative Impacts of Non-native Species /$rRadu Cornel Guia?u -- $tPositive Contributions of Introduced Species /$rRadu Cornel Guia?u -- $tChanging Ecosystems and Impacts of Introduced Species over Time /$rRadu Cornel Guia?u -- $tThe Endless War on Invasive Species ? Control and Eradication Programs /$rRadu Cornel Guia?u -- $tSome Conclusions and Some Questions /$rRadu Cornel Guia?u -- $tLiterature Cited /$rRadu Cornel Guia?u -- $tIndex /$rRadu Cornel Guia?u. 330 $aThe young field of invasion biology - initially a branch of ecology and conservation biology - has greatly expanded, particularly in the last two and a half decades or so. As a result, the potential negative effects of introduced species have been widely advertised and sometimes, perhaps, overemphasized. This book attempts to restore some balance to the current debate over the role of non-native species, by offering a broader perspective, and taking a longer term, evolutionary look at these species and their impact in their new environments. The relatively arbitrary nature of terms such as \'native\' and \'non-native\', and the rather inconsistent ways in which such terms are applied to biological species, as well as the subjective boundaries of so-called \'native ranges\' are analyzed. The role of non-native species in their new environments can be considerably more complex than the anti-introduced species information would often suggest. Thus, the more positive and nuanced perspective on introduced species and their impact offered in this book is much needed and long overdue. 606 $aIntroduced organisms$xEnvironmental aspects 608 $aElectronic books. 615 0$aIntroduced organisms$xEnvironmental aspects. 676 $a578.6/2 700 $aGuias?u$b Radu Cornel$01043769 801 0$bNL-LeKB 801 1$bNL-LeKB 906 $aBOOK 912 $a9910493199603321 996 $aNon-native species and their role in the environment$92468966 997 $aUNINA LEADER 05294nam 2200673 a 450 001 9910457469003321 005 20200520144314.0 010 $a1-283-32021-5 010 $a9786613320216 010 $a0-12-391913-4 035 $a(CKB)2550000000062029 035 $a(EBL)802460 035 $a(OCoLC)763157847 035 $a(SSID)ssj0000589375 035 $a(PQKBManifestationID)12290823 035 $a(PQKBTitleCode)TC0000589375 035 $a(PQKBWorkID)10656639 035 $a(PQKB)10049457 035 $a(MiAaPQ)EBC802460 035 $a(PPN)190226498 035 $a(Au-PeEL)EBL802460 035 $a(CaPaEBR)ebr10509955 035 $a(EXLCZ)992550000000062029 100 $a20111119d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aClinical trials$b[electronic resource] $estudy design, endpoints and biomarkers, drug safety, FDA and ICH guidelines /$fTom Brody 205 $a1st ed. 210 $aLondon $cAcademic Press$d2012 215 $a1 online resource (673 p.) 300 $aDescription based upon print version of record. 311 $a0-12-391911-8 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, FDA and ICH Guidelines; Copyright Page; Contents; Acknowledgments; Preface; The Study Schema and Study Design; Intent to Treat Analysis; How to Choose the Endpoints; Diagnostic Tests; Mechanism of Action; Standards; Methodology; Clinicaltrials.Gov and other Registries for Clinical Trials; Introduction; Abbreviations and Definitions; Biography; 1 The Origins of Drugs; I. Introduction; II. Structures of Drugs; a. Origins of warfarin; b. Origins of methotrexate and 5-fluorouracil; c. Origins of ribavirin 327 $ad. Origins of paclitaxele. Origins of cladribine; f. Origins of drugs in high-throughput screening; g. Origins of therapeutic antibodies; III. The 20 Classical Amino Acids; IV. Animal Models; a. Introduction; b. Estimating human dose from animal studies; 1. NOAEL approach; 2. MABEL approach; c. Scaling up the drug dose, acquired from animal studies, for use in humans; 2 Introduction to Regulated Clinical Trials; I. Introduction; II. Study Design; III. The Study Schema; a. Examples of schema from clinical trials; b. Sequential treatment versus concurrent treatment - the Perez schema 327 $ac. Neoadjuvant chemotherapy versus adjuvant chemotherapy - the Gianni schemad. Neoadjuvant chemotherapy plus adjuvant chemotherapy - the Untch schema; e. Forwards sequence and reverse sequence - the Puhalla schema; f. Both arms received three drugs, each arm at a different schedule - the Sekine schema; g. Staging - the Blumenschein schema; h. Staging and restaging - the Czito schema; i. Methodology tip - staging; j. Decision tree - the Baselga schema; k. Decision tree - the Katsumata schema; l. Methodology tip - what is "tumor progression"? 327 $am. Methodology tip - unit of drug dose expressed in terms of body surface arean. Run-in period - the schema of Dy; o. Methodology tip - c-kit and imatinib; p. Run-in period - the Hanna schema; q. How to maintain blinding of the treatment, when the study drug and the control treatment are provided by different-sized pills (or by different volumes of solutions)...; r. Methodology tip - bevacizumab and VEGF; s. Dose escalation - the Moore schema; t. Pharmacokinetics - the Marshall schema; IV. Further Concepts In Study Design; a. Active control; b. Add-on design active control 327 $ac. Three-arm study - clinical trial with two different active control armsV. Summary; VI. Amendments to the Clinical Study Protocol; 3 Run-In Period; I. Introduction; a. Washout period; b. Detecting baseline adverse events; c. Excluding potential study subjects who have safety issues correlating with the study drug; d. To include only study subjects with controllable pain; e. To determine the maximal tolerable dose; f. To achieve and ensure steady state in vivo concentrations of study drug 327 $ag. To allow a period of adjustment of lifestyle of the study subjects, for example changes in dietary patterns 330 $aClinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines is a practical guidebook for those engaged in clinical trial design. This book details the organizations and content of clinical trials, including trial design, safety, endpoints, subgroups, HRQoL, consent forms and package inserts. It provides extensive information on both US and international regulatory guidelines and features concrete examples of study design from the medical literature. This book is intended to orient those new to clinical trial design and provide them with a better u 606 $aClinical trials 606 $aDrugs$xTesting 608 $aElectronic books. 615 0$aClinical trials. 615 0$aDrugs$xTesting. 676 $a615.19 676 $a615.50724 676 $a615/.19 700 $aBrody$b Tom$0481636 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910457469003321 996 $aClinical trials$92014849 997 $aUNINA LEADER 01090nam a2200277 i 4500 001 991001997559707536 005 20020503155831.0 008 001108s1996 it ||| | ita 020 $a882224446X 035 $ab10302232-39ule_inst 035 $aEXGIL95822$9ExL 040 $aBiblioteca Interfacoltà$bita 082 04$a016.34845411 100 1 $aZanardi, Zita$0297368 245 10$aBononia manifesta :$bcatalogo dei bandi, editti, costituzioni e provvedimenti diversi, stampati nel 16. secolo per Bologna e il suo territorio /$ca cura di Zita Zanardi 260 $aFirenze :$bL. S. Olschki,$c1996 300 $axxxiii, 571 p. ;$c25 cm. 490 0 $aBiblioteca di bibliografia italiana ;$v142 651 4$aBologna$xLegislazione$ySec. 16. 907 $a.b10302232$b17-02-17$c27-06-02 912 $a991001997559707536 945 $aLE002 SB 348 ZAN 945 $aLE002 Bibl. I E 28$g1$i2002000010162$lle002$o-$pE0.00$q-$rn$so $t0$u0$v0$w0$x0$y.i10357208$z27-06-02 996 $aBononia manifesta$9201969 997 $aUNISALENTO 998 $ale002$b01-01-00$cm$da $e-$fita$git $h0$i1 LEADER 03639nam 2200601 450 001 9910828835603321 005 20170828133207.0 010 $a0-8218-7777-1 010 $a0-8218-5523-9 035 $a(CKB)3240000000069715 035 $a(EBL)3112932 035 $a(SSID)ssj0000712589 035 $a(PQKBManifestationID)11374767 035 $a(PQKBTitleCode)TC0000712589 035 $a(PQKBWorkID)10644613 035 $a(PQKB)10333895 035 $a(MiAaPQ)EBC3112932 035 $a(WaSeSS)Ind00039519 035 $a(RPAM)3032862 035 $a(PPN)228542790 035 $a(EXLCZ)993240000000069715 100 $a19950406h19951995 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRecent developments in the inverse Galois problem $ea Joint Summer Research Conference on Recent Developments in the Inverse Galois problem, July 17-23, 1993, University of Washington, Seattle /$fMichael D. Fried, coordinating editor ; Shreeram S. Abhyankar [and three others], editors 210 1$aProvidence, Rhode Island :$cAmerican Mathematical Society,$d[1995] 210 4$d©1995 215 $a1 online resource (416 p.) 225 1 $aContemporary mathematics,$x0271-4132 ;$v186 300 $aDescription based upon print version of record. 311 $a0-8218-0299-2 320 $aIncludes bibliographical references. 327 $a""Contents""; ""Preface""; ""Part A: Explicit Quotients of GQ and GF(t)""; ""Explicit Galois realization of C16-extensions of An and Sn""; ""Topics in Galois theory""; ""Parametric solutions of embedding problems""; ""Some projective linear groups over finite fields as Galois groups over Q""; ""K-admissibility of metacyclic 2-groups""; ""Embedding problems and the C16 a??? C8 obstruction""; ""Cyclic covers of P1 and Galois action on their division points""; ""Part B: Moduli Spaces and the Structure of GQ"" 327 $a""Introduction to modular towers: Generalizing dihedral group-modular curve connections""""On Galois actions on profinite completions of braid groups""; ""On the Galois image in the derivation algebra of I??1 of the projective line minus three points""; ""Part C: The Structure of GR(t), GFq(t), and GQp(t)""; ""Covers of P1 over the N??-adics""; ""Existence de points p-adiques pour tout p sur un espace de Hurwitz""; ""Stable models""; ""Tout groupe fini est un groupe de Galois sur Qp(T), d'apres Harbater""; ""Specializations of coverings and their Galois groups"" 327 $a""Rational points and canonical heights on K3-surfaces in P1 x P1 x P1""""Part D: Group Theory and Geometric Monodromy Groups""; ""Mathieu group coverings and linear group coverings""; ""Fundamental groups for arbitrary categories""; ""Monodromy groups of branched coverings: The generic case""; ""Fundamental groups and embedding problems in characteristic p""; ""On free profinite groups of uncountable rank""; ""Primitive monodromy groups of polynomials"" 410 0$aContemporary mathematics (American Mathematical Society) ;$v186. 606 $aInverse Galois theory$vCongresses 615 0$aInverse Galois theory 676 $a512/.3 702 $aFried$b Michael D.$f1942- 702 $aAbhyankar$b Shreeram Shankar 712 02$aAmerican Mathematical Society, 712 12$aJoint Summer Research Conference on Recent Developments in the Inverse Galois Problem 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828835603321 996 $aRecent developments in the inverse Galois problem$9381968 997 $aUNINA