LEADER 00950nam a2200265 i 4500 001 991001962479707536 005 20020507154528.0 008 000516s1994 it ||| | ita 020 $a8824311059 035 $ab11589383-39ule_inst 035 $aLE02728141$9ExL 040 $aDip.to Studi Giuridici$bita 084 $aCM-XI/A 100 1 $aMassa, Giovanni$0252117 245 10$aFunzione attrattiva e autonomia del marchio /$cGiovanni Massa 260 $aNapoli :$bJovene,$c1994 300 $ax, 189 p. ;$c24 cm. 490 0 $aOsservatorio di leggi e di attualitą giuridiche ;$v2 650 4$aMarchi di fabbrica 907 $a.b11589383$b01-03-17$c02-07-02 912 $a991001962479707536 945 $aLE027 CM-XI/A 15$g1$iLE027-474$lle027$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i11798749$z02-07-02 996 $aFunzione attrattiva e autonomia del marchio$9633502 997 $aUNISALENTO 998 $ale027$b01-01-00$cm$da $e-$fita$git $h0$i1 LEADER 04007nam 2200505 450 001 9910808613003321 005 20230811075730.0 010 $a1-119-28921-1 010 $a1-119-28922-X 010 $a1-119-28923-8 035 $a(CKB)4330000000009992 035 $a(MiAaPQ)EBC5709855 035 $a(OCoLC)1061865433 035 $a(CaSebORM)9781119289197 035 $a(EXLCZ)994330000000009992 100 $a20190301d2019 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aQuantitative pharmacology and individualized therapy strategies in development of therapeutic proteins for immune-mediated inflammatory diseases /$fedited by Honghui Zhou, Diane R. Mould 205 $a1st edition 210 1$aHoboken, NJ :$cWiley,$d2019. 215 $a1 online resource (530 pages) $cillustrations 225 1 $aTHEi Wiley ebooks 311 $a1-119-28919-X 320 $aIncludes bibliographical references and index. 330 $aThorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: ?          Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins ?          Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) ?          Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould?s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders. 410 0$aTHEi Wiley ebooks. 606 $aImmunologic diseases 606 $aImmunologic diseases$xTreatment 615 0$aImmunologic diseases. 615 0$aImmunologic diseases$xTreatment. 676 $a616.079 700 $aZhou$b Honghui$01669465 702 $aMould$b Diane R. 702 $aZhou$b Honghui 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808613003321 996 $aQuantitative pharmacology and individualized therapy strategies in development of therapeutic proteins for immune-mediated inflammatory diseases$94030627 997 $aUNINA