LEADER 01038nam0-22003371i-450- 001 990008442970403321 005 20061221113204.0 020 $aIT$b736484 035 $a000844297 035 $aFED01000844297 035 $a(Aleph)000844297FED01 035 $a000844297 100 $a20061221e19721765km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aMemorie istoriche dell'antichissima e regia citta di Jesi$fGirolamo Baldassini 210 $aBologna$cForni$dstampa 1972 215 $aXXIV, 392, CLXIV, 19 p.$d25 cm 225 1 $aBiblioteca istorica della antica e nuova Italia 300 $aRist. anast. dell'ed.: Jesi : Bonelli, 1765 676 $a945.671$v21$zita 676 $a945.671$v21$zita 700 1$aBaldassini,$bGirolamo$0320731 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008442970403321 952 $aSDI-XXIII G 15$b357$fSDI 959 $aSDI 996 $aMemorie istoriche dell'antichissima e regia citta di Jesi$9728127 997 $aUNINA LEADER 05491nam 2200685Ia 450 001 9910144298603321 005 20170925023710.0 010 $a1-280-51948-7 010 $a9786610519484 010 $a3-527-60375-1 010 $a3-527-60384-0 035 $a(CKB)1000000000376379 035 $a(EBL)481511 035 $a(OCoLC)69243366 035 $a(SSID)ssj0000211433 035 $a(PQKBManifestationID)11201930 035 $a(PQKBTitleCode)TC0000211433 035 $a(PQKBWorkID)10293010 035 $a(PQKB)11149194 035 $a(MiAaPQ)EBC481511 035 $a(EXLCZ)991000000000376379 100 $a20040716d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNitric oxide donors$b[electronic resource] $efor pharmaceutical and biological applications /$fedited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi 210 $aWeinheim ;$a[Great Britain] $cWiley-VCH$dc2005 215 $a1 online resource (414 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31015-0 320 $aIncludes bibliographical references and index. 327 $aNitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer 327 $a1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 327 $a2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 327 $a3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 327 $a3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 327 $a4.2.1 Regulation of Blood Flow by HbSNO 330 $aNitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances. 606 $aNitric oxide 606 $aNitric oxide$xPhysiological effect 606 $aDrugs$xDesign 606 $aPharmaceutical chemistry 608 $aElectronic books. 615 0$aNitric oxide. 615 0$aNitric oxide$xPhysiological effect. 615 0$aDrugs$xDesign. 615 0$aPharmaceutical chemistry. 676 $a572.54 701 $aWang$b Peng George$0738023 701 $aCai$b Tingwai Bill$0946298 701 $aTaniguchi$b Naoyuki$f1942-$0864851 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144298603321 996 $aNitric oxide donors$92137946 997 $aUNINA LEADER 01141nam a2200289 i 4500 001 991001530549707536 008 030402s2002 enko b 001 0 eng d 020 $a0415278600 (hbk) 020 $a0415278619 (pbk) 035 $ab12160209-39ule_inst 040 $aDip.to Lingue $bita 245 00$aBritish Cultural Identities /$cedited by Mike Storry and Peter Childs 250 $a2. ed. 260 $aLondon ;$aNew York :$bRoutledge,$c2002 300 $axiv, 303 p. :$bill. ;$c25 cm 504 $aContiene riferimenti bibliografici ed indice 651 4$aGran Bretannia$xVita sociale e costumi 651 4$aGran Bretannia$xCivilizzazione 700 1 $aStorry, Mike 700 1 $aChilds, Peter 907 $a.b12160209$b24-11-06$c02-04-03 912 $a991001530549707536 945 $aLE012 305.821 STO$g1$i2012000037670$lle012$o-$pE0.00$q-$rl$s- $t0$u7$v12$w7$x0$y.i1249222x$z02-04-03 945 $aLE012 305.821 STO 1/A$g2$i2012000111745$lle012$o-$pE0.00$q-$rl$s- $t0$u12$v5$w12$x0$y.i1432488x$z24-11-06 996 $aBritish Cultural Identities$9148009 997 $aUNISALENTO 998 $ale012$b02-04-03$cm$da $e-$feng$genk$h0$i1