LEADER 00898nam a2200265 i 4500 001 991001316399707536 005 20020507191227.0 008 980127s1971 uk ||| | eng 035 $ab10830595-39ule_inst 035 $aLE01310397$9ExL 040 $aDip.to Matematica$beng 082 0 $a510 084 $aZDM F03 110 2 $aSMP$0536732 245 14$aThe School mathematics project :$bteacher's guide /$cSMP 250 $ametric repr 260 $aCambridge :$bCambridge University Press,$c1971 300 $a304 p. ;$c23 cm. 650 4$aDidactis of mathematics 907 $a.b10830595$b21-09-06$c28-06-02 912 $a991001316399707536 945 $aLE013 F03 SMP113 (1971)$g1$i2013000094540$lle013$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i10939246$z28-06-02 996 $aSchool mathematics project$9923660 997 $aUNISALENTO 998 $ale013$b01-01-98$cm$da $e-$feng$guk $h4$i1 LEADER 03770nam 2200589 450 001 9910688234703321 005 20230621135618.0 010 $a9782889193011$b(ebook) 035 $a(CKB)3710000000586897 035 $a(SSID)ssj0001683374 035 $a(PQKBManifestationID)16509370 035 $a(PQKBTitleCode)TC0001683374 035 $a(PQKBWorkID)15038052 035 $a(PQKB)10228167 035 $a(WaSeSS)IndRDA00056691 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54572 035 $a(EXLCZ)993710000000586897 100 $a20160829d2014 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNew edge of antibiotic development $eantimicrobial peptides and corresponding resistance /$ftopic editors: Nádia S. Parachin and Octavio L. Franco 210 $cFrontiers Media SA$d2014 210 31$aFrance :$cFrontiers Media SA,$d2014 215 $a1 online resource (144 pages) $cillustrations (colour); digital file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aIncreased pathogen resistance to conventional drugs is partially due to increased numbers of immune-compromised patients, therefore the development of alternative antibiotic therapies able to circumvent this problem is one of the intriguing challenges of modern medicine. The discovery of antimicrobial peptides has been considered, in recent years, to be essential for the solution to infections caused by bacterial and fungal diseases, owing to their commonly observed and naturally occurring resistance against pathogens. In addition to the obvious antimicrobial activity commonly associated with membrane disruption, such peptides also have shown auxiliary activities such as immunomodulatory, anti-tumor and biofilm-disruption. Moreover, antibiotic peptides have been considered critical as therapeutic agents for the control of infectious bacterial diseases; the resistance to antibiotics has become a globally recognized public health problem. In most bacterial species, after exposing microorganisms to antibiotic peptides, several systems are affected such as energy and nitrogen metabolism regulation, glucan biosynthesis, amino acid, protein, and nucleotide synthesis, and, moreover, various proteins show a stress response. Despite some articles having been published about bacterial resistance toward antimicrobial peptides, multiple gaps need to be filled in order to better understand this mechanism. In this view, this edition proposes the analyses of these unusual and interesting peptides and will provide a clearer understanding of such bacterial resistance towards AMPs. In summary, this proposal focuses on AMPs and their multiple activities as well as on AMP bacterial resistance, attracting several researchers from different areas. 606 $aPharmacy, Therapeutics, & Pharmacology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $apathogenic bacteria 610 $aFungi 610 $anatural 610 $apeptide design 610 $aproteinase inhibitors 610 $aBacterial resistance 610 $avirus 610 $aantimicrobial peptides 610 $aself-assembled structures 615 7$aPharmacy, Therapeutics, & Pharmacology 615 7$aHealth & Biological Sciences 700 $aNadia S. Parachin$4auth$01352893 702 $aFranco$b Octavio L 702 $aParachin$b Nádia S 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910688234703321 996 $aNew edge of antibiotic development$93205464 997 $aUNINA