LEADER 01308cam0-22003611i-450 001 990005864740403321 005 20220415123544.0 010 $a84-376-1643-3 035 $a000586474 035 $aFED01000586474 035 $a(Aleph)000586474FED01 035 $a000586474 100 $a20000421g19989999km-y0itay50------ba 101 0 $aspa 102 $aES 105 $ay-------001yy 200 1 $aHistoria de la prosa medieval castellana$fFernando Gómez Redondo 210 $aMadrid$cCatedra$d1998- 215 $av.$d21 cm 225 1 $aCritica y estudios literarios 327 0 $a1.: La creación del discurso prosistico : el entramado cortesano. - 1998$a2.: El desarollo de los géneros. La ficción caballeresca y el orden religioso. - 1999$a3.: Los origenes del humanismo. El marco cultural de Enrique 3. y Juan 2. - 2002 610 0 $aNarrativa spagnola$aSec.11.-15. 676 $a863.109$v20$zita 700 1$aGómez Redondo,$bFernando$0388669 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990005864740403321 952 $a863.109 GOM 1(1)$bBibl.28518$fFLFBC 952 $a863.109 GOM 1(2)$bBibl.31087$fFLFBC 952 $a863.109 GOM 1(3)$bDip.f.m.11953$fFLFBC 959 $aFLFBC 996 $aHistoria de la prosa medieval castellana$91056961 997 $aUNINA LEADER 01074nmm a22002775u 4500 001 991001286869707536 007 cr nn 008mamaa 008 100725s2009 us j eng d 020 $a9780817646127 035 $ab13990639-39ule_inst 040 $aDip.to Matematica$beng 100 1 $aGiaquinta, Mariano$042383 245 10$aMathematical analysis$h[e-book] :$ban introduction to functions of several variables /$cby Mariano Giaquinta, Giuseppe Modica 260 $aBoston, MA :$bBirkhäuser,$c2009 300 $bv.: digital 650 0$aMathematics 650 0$aGlobal analysis (Mathematics) 650 0$aDifferential equations 700 1 $aModica, Giuseppe$eauthor$4http://id.loc.gov/vocabulary/relators/aut$056742 773 0 $aSpringer eBooks 856 40$uhttp://dx.doi.org/10.1007/978-0-8176-4612-7$zAn electronic book accessible through the World Wide Web 907 $a.b13990639$b03-03-22$c28-06-11 912 $a991001286869707536 996 $aMathematical analysis$91416441 997 $aUNISALENTO 998 $ale013$b28-06-11$cm$d@ $e-$feng$gus $h0$i0 LEADER 05339nam 2200649Ia 450 001 9910830685003321 005 20240301125450.0 010 $a1-281-31169-3 010 $a9786611311698 010 $a3-527-61197-5 010 $a3-527-61199-1 010 $a9783527313778 010 $a9783527611973 010 $a9783527611997 035 $a(CKB)1000000000441537 035 $a(EBL)482133 035 $a(OCoLC)609855541 035 $a(SSID)ssj0000299045 035 $a(PQKBManifestationID)11254046 035 $a(PQKBTitleCode)TC0000299045 035 $a(PQKBWorkID)10240357 035 $a(PQKB)10315277 035 $a(MiAaPQ)EBC482133 035 $a(EXLCZ)991000000000441537 100 $a20050624d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHPLC made to measure$b[electronic resource] $ea practical handbook for optimization /$fedited by Stavros Kromidas 210 $aWeinheim $cWiley-VCH ;$a[Chichester $cJohn Wiley, distributor]$dc2006 215 $a1 online resource (789 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31377-X 320 $aIncludes bibliographical references and index. 327 $aHPLC Made to Measure; Foreword; Preface; Contents; List of Contributors; Structure of the Book; 1 Fundamentals of Optimization; 1.1 Principles of the Optimization of HPLC Illustrated by RP-Chromatography; 1.1.1 Before the First Steps of Optimization; 1.1.2 What Exactly Do We Mean By "Optimization"?; 1.1.3 Improvement of Resolution ("Separate Better"); 1.1.3.1 Principal Possibilities for Improving Resolution; 1.1.3.2 What has the Greatest Effect on Resolution?; 1.1.3.3 Which Sequence of Steps is Most Logical When Attempting an Optimization?; 1.1.3.4 How to Change k, ?, and N 327 $a1.1.3.4.1 Isocratic Mode1.1.3.4.2 Gradient Mode; 1.1.3.4.3 Acetonitrile or Methanol?; 1.1.4 Testing of the Peak Homogeneity; 1.1.5 Unknown Samples: "How Can I Start?"; Strategies and Concepts; 1.1.5.1 The "Two Days Method"; 1.1.5.2 "The 5-Step Model"; 1.1.6 Shortening of the Run Time ("Faster Separation"); 1.1.7 Improvement of the Sensitivity ("To See More", i.e. Lowering of the Detection Limit); 1.1.8 Economics in HPLC ("Cheaper Separation"); 1.1.9 Final Remarks and Outlook; References; 1.2 Fast Gradient Separations; 1.2.1 Introduction; 1.2.2 Main Part; 1.2.2.1 Theory; 1.2.2.2 Results 327 $a1.2.2.2.1 General Relationships1.2.2.2.2 Short Columns, Small Particles; 1.2.2.2.3 An Actual Example; 1.2.2.3 Optimal Operating Conditions and Limits of Currently Available Technology; 1.2.2.4 Problems and Solutions; 1.2.2.4.1 Gradient Delay Volume; 1.2.2.4.2 Detector Sampling Rate and Time Constant; 1.2.2.4.3 Ion Suppression in Mass Spectrometry; References; 1.3 pH and Selectivity in RP-Chromatography; 1.3.1 Introduction; 1.3.2 Main Section; 1.3.2.1 Ionization and pH; 1.3.2.2 Mobile Phase and pH; 1.3.2.2.1 Buffer Capacity 327 $a1.3.2.2.2 Changes of pK and pH Value in the Presence of an Organic Solvent1.3.2.3 Buffers; 1.3.2.3.1 Classical HPLC Buffers; 1.3.2.3.2 MS-Compatible pH Control; 1.3.2.4 Influence of the Samples; 1.3.2.4.1 The Sample Type: Acids, Bases, Zwitterions; 1.3.2.4.2 Influence of the Organic Solvent on the Ionization of the Analytes; 1.3.3 Application Example; 1.3.4 Troubleshooting; 1.3.4.1 Reproducibility Problems; 1.3.4.2 Buffer Strength and Solubility; 1.3.4.3 Constant Buffer Concentration; 1.3.5 Summary; References; 1.4 Selecting the Correct pH Value for HPLC; 1.4.1 Introduction 327 $a1.4.2 Typical Approaches to pH Selection1.4.3 Initial pH Selection; 1.4.4 Basis of pK(a) Prediction; 1.4.5 Correction of pH Based on Organic Content; 1.4.6 Optimization of Mobile Phase pH Without Chemical Structures; 1.4.7 A Systematic Approach to pH Selection; 1.4.8 An Example - Separation of 1,4-Bis[(2-pyridin-2-ylethyl)thio]butane-2,3-diol from its Impurities; 1.4.9 Troubleshooting Mobile Phase pH; 1.4.10 The Future; 1.4.11 Conclusion; References; 1.5 Optimization of the Evaluation in Chromatography; 1.5.1 Evaluation of Chromatographic Data - An Introduction; 1.5.2 Working Range 327 $a1.5.3 Internal Standard 330 $aThe only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness. This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in 606 $aHigh performance liquid chromatography$xMethodology 606 $aLiquid chromatography 615 0$aHigh performance liquid chromatography$xMethodology. 615 0$aLiquid chromatography. 676 $a543.0894 676 $a543.84 701 $aKromidas$b Stavros$01604367 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830685003321 996 $aHPLC made to measure$93929163 997 $aUNINA