LEADER 00970nam a2200265 i 4500 001 991000905269707536 005 20020507175604.0 008 950102s1968 us ||| | eng 035 $ab10773769-39ule_inst 035 $aLE01304110$9ExL 040 $aDip.to Matematica$beng 084 $aAMS 51-XX 100 1 $aGolos, Ellery B.$0535424 245 10$aFoundations of Euclidean and non-Euclidian geometry /$cEllery B. Golos 260 $aNew York :$bHolt, Rinehart and Winston,$cc1968 300 $aix, 225 p. ;$c23 cm. 650 4$aEuclidean geometries 650 4$aGeometry 650 4$aNon-Euclidean geometry 907 $a.b10773769$b21-09-06$c28-06-02 912 $a991000905269707536 945 $aLE013 51-XX GOL11 (1968)$g1$i2013000017877$lle013$o-$pE0.00$q-$rl$s- $t0$u3$v0$w3$x0$y.i10872498$z28-06-02 996 $aFoundations of Euclidean and non-Euclidian geometry$9922670 997 $aUNISALENTO 998 $ale013$b01-01-95$cm$da $e-$feng$gus $h0$i1 LEADER 06828nam 22007575 450 001 9910736011003321 005 20230822194823.0 010 $a981-19-9776-4 024 7 $a10.1007/978-981-19-9776-1 035 $a(MiAaPQ)EBC30669134 035 $a(Au-PeEL)EBL30669134 035 $a(DE-He213)978-981-19-9776-1 035 $a(PPN)27225536X 035 $a(CKB)27878834400041 035 $a(EXLCZ)9927878834400041 100 $a20230729d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHandbook of Chemical Biology of Nucleic Acids /$fedited by Naoki Sugimoto 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (2847 pages) 311 08$aPrint version: Sugimoto, Naoki Handbook of Chemical Biology of Nucleic Acids Singapore : Springer,c2023 9789811997754 327 $aHigh-Pressure Single-Molecule Studies on Non-canonical Nucleic Acids and Their Interactions -- Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids -- The Effect of Pressure on the Conformational Stability of DNA -- Quadruplexes are everywhere?on the other strand too: the i-motif -- i-Motif Nucleic Acids -- NMR Study on Nucleic Acids -- Z-DNA -- Structures of DNA G-quadruplexes and Their Drug Interactions -- In cell 19F NMR for G-quadruplex -- Structures and Catalytic Activities of Complexes between Heme and DNA -- Studying nucleic acid-ligand binding by X-ray crystallography -- Predicting the 3D structure of RNA from sequence -- XNA in Synthetic Biology -- The Effects of FANA Modifications on Non-Canonical Nucleic Acid Structures -- Isomorphic Fluorescent Nucleoside Analogs -- Bridged Nucleic Acids for Therapeutic Oligonucleotides -- Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents -- Chemistry of Cyclic Dinucleotides and Analogs -- Labeling and Detection of Modified Nucleic Acids -- Cross linking Duplex of Nucleic Acids with Modified Oligonucleotides -- Enzymatic Synthesis of Base-Modified Nucleic Acids -- Charge Transfer in Natural and Artificial Nucleic Acids -- Nucleic Acid Aptamers: From Basic Research to Clinical Applications -- LNA in Medical Biology -- Targeting Quadruplex Nucleic Acids: The Bisquinolinium Saga -- Compound Shape and Substituent Effects in DNA Minor Groove Interactions -- Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs -- Cyclic Naphthalene Diimide Derivatives as Novel DNA Ligands -- Imaging study of small molecules to G-quadruplexes in cells -- Bivalent Nucleic Acid Ligands -- DNA/Metal Cluster?Based Nano-Lantern -- Interaction of Poly (ethylene glycol)-b-poly-L-lysine Copolymers with DNA Structures: A Thermodynamic Investigation -- Chemical tools to target non-coding RNAs -- Targeting DNA junctions with small molecules for therapeutic applications in oncology -- DNA Damage and Repair in G-quadruplexes Impact Gene Expression -- DNA Structural Elements as Potential Targets for Regulation of Gene Expression -- Effects of molecular crowding on structures and functions of nucleic acids -- Structure-guided Optimization of siRNA and anti-miRNA Properties -- Tools for understanding the chemical biology of the tRNA epitranscriptome -- Sulfur and Selenium modified bacterial tRNAs -- Chemical-assisted Epigenome Sequencing -- Epitranscriptomics. Telomeres and Telomerase -- Genetic Alphabet Expansion of Nucleic Acids -- Unnatural Base Pairs to Expand the Genetic Alphabet and Code -- OGG1 at the crossroads between repair and transcriptional regulation -- Phosphorothioate Nucleic Acids - Artificial Modification Envisaged by Nature -- Aptamer Molecular Evolution for Liquid Biopsy -- Functions and Applications of Riboswitches -- PNA and Quadruplex -- Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies -- Structure and Function of Aptamer and Catalytic DNA -- Origin and Evolution of RNA -- Targeting RNA with Small Molecules. 330 $aThis handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications. 606 $aBiomaterials 606 $aNucleic acids 606 $aBiochemistry 606 $aChemistry, Organic 606 $aBiotechnology 606 $aNanochemistry 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aNucleic Acid 606 $aChemical Biology 606 $aOrganic Chemistry 606 $aBiotechnology 606 $aNanochemistry 606 $aBiomedical Research 615 0$aBiomaterials. 615 0$aNucleic acids. 615 0$aBiochemistry. 615 0$aChemistry, Organic. 615 0$aBiotechnology. 615 0$aNanochemistry. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aNucleic Acid. 615 24$aChemical Biology. 615 24$aOrganic Chemistry. 615 24$aBiotechnology. 615 24$aNanochemistry. 615 24$aBiomedical Research. 676 $a620.19 676 $a547.7 700 $aSugimoto$b Naoki$01380149 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910736011003321 996 $aHandbook of Chemical Biology of Nucleic Acids$93421441 997 $aUNINA