LEADER 01138nam a2200337 i 4500 001 991000815959707536 005 20020507173940.0 008 931108s1980 us ||| | eng 020 $a0387904190 035 $ab10761160-39ule_inst 035 $aLE01302751$9ExL 040 $aDip.to Matematica$beng 082 0 $a516.3604 084 $aAMS 58B 084 $aAMS 58C 084 $aAMS 58G 084 $aQA613.W44 100 1 $aWells, Raimond O'Neil jr.$0534947 245 10$aDifferential analysis on complex manifolds /$cRaimond O'Neil Wells 250 $a2nd ed 260 $aNew York :$bSpringer-Verlag,$c1980 300 $ax, 260 p. ;$c24 cm. 490 0 $aGraduate texts in mathematics,$x0072-5285 ;$v65 650 0$aComplex manifolds 650 0$aDifferentiable manifolds 907 $a.b10761160$b23-02-17$c28-06-02 912 $a991000815959707536 945 $aLE013 58B WEL11 (1980)$g1$i2013000071244$lle013$o-$pE0.00$q-$rl$s- $t0$u11$v7$w11$x0$y.i10856390$z28-06-02 996 $aDifferential analysis on complex manifolds$9923063 997 $aUNISALENTO 998 $ale013$b01-01-93$cm$da $e-$feng$gus $h0$i1 LEADER 05878nam 22006615 450 001 9910574051203321 005 20251113184200.0 010 $a3-030-98331-5 024 7 $a10.1007/978-3-030-98331-4 035 $a(MiAaPQ)EBC7008974 035 $a(Au-PeEL)EBL7008974 035 $a(CKB)23231031100041 035 $aEBL7008974 035 $a(AU-PeEL)EBL7008974 035 $a(OCoLC)1328134745 035 $a(DE-He213)978-3-030-98331-4 035 $a(EXLCZ)9923231031100041 100 $a20220603d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHair Follicle Regeneration /$fedited by Francisco Jimenez, Claire Higgins 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2022. 215 $a1 online resource (310 pages) 225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v72 300 $aDescription based upon print version of record. 311 08$aPrint version: Jimenez, Francisco Hair Follicle Regeneration Cham : Springer International Publishing AG,c2022 9783030983307 320 $aIncludes bibliographical references and index. 327 $aChapter 1. The historical studies underpinning the concept of hair follicle neogenesis (Higgins C, Jahoda C) -- Chapter 2. Hair regeneration and rejuvenation: pipeline of medical and technical strategies (Limbu S, Kemp P) -- Chapter 3. Cells and structures involved in hair follicle regeneration: an introduction (Tsai J, Garza LA) -- Chapter 4. The dermal papilla and hair follicle regeneration: Engineering strategies to improve dermal papilla inductivity (Pantelireis N, Clavel C) -- Chapter 5. Dermal sheath and hair follicle regeneration (Yoshida Y, Tsuboi K, Kishimoto J) -- Chapter 6. Epithelial-mesenchymal interactions between hair follicles and dermal adipose tissue (Ramos R, Plikus MV) -- Chapter 7. Lymphatic vasculature and hair follicle regeneration (Cazorla A, Perez-Moreno M) -- Chapter 8. In vitro and ex vivo hair follicle models to explore therapeutic options for hair regeneration (Bertolini M, Piccini I, McElwee KJ) -- Chapter 9. Extracellular vesicles including exosomes for hair follicle regeneration (Aberdam E, le Riche A, Bordes S, Closs B, Park BS, Aberdam D) -- Chapter 10. Stem cell-based therapies for hair loss: what is the evidence from a clinical perspective? (Park BS, Choi HI) -- Chapter 11. Induced pluripotent stem cell approach for hair follicle regeneration (Pinto A, Terskikh AV) -- Chapter 12. Biofabrication technologies in hair neoformation (Abreu CM, Gasperini L, Marques AP) -- Chapter 13. Wound healing induced hair follicle regeneration (Jiang Y, Myung P) -- Chapter 14. Hair follicles in wound healing and skin remodeling (Plotczyk M, Jimenez F) . 330 $aThis book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex ?mini-organ? has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis. The idea of human hair follicle regeneration either ?de novo? or by activating dormant miniaturized follicles is not new, yet still continues to arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology?as well as the appearance of new technologies like 3D printing?have revived expectations in this field of research. This book is divided into four sections. The first part includes an overview of the strategies used in hair follicle regeneration and a historical summary of the most important achievements to date. Parts two and three comprise the main body of the book, with detailed descriptions of the cells and tissue structures involved in hair follicle regeneration, followed by an elaboration of the different therapeutic strategies, engineering techniques, and a clinician?s perspective of stem cell-based therapies in hair loss treatments. Finally, the fourth part reviews the important contribution of the hair follicle in healing cutaneous wounds through the regeneration and remodeling of the dermis and epidermis after injury, as well as wound induced hair follicle neogenesis that occurs when the skin is injured. 410 0$aStem Cell Biology and Regenerative Medicine,$x2196-8993 ;$v72 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aStem cells 606 $aBiotechnology 606 $aBiomedical Research 606 $aStem Cell Biology 606 $aBiotechnology 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aStem cells. 615 0$aBiotechnology. 615 14$aBiomedical Research. 615 24$aStem Cell Biology. 615 24$aBiotechnology. 676 $a612.799 702 $aJime?nez$b Francisco 702 $aHiggins$b Claire 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910574051203321 996 $aHair follicle regeneration$92994697 997 $aUNINA