LEADER 05337nam 2200661Ia 450 001 9910455572103321 005 20200520144314.0 010 $a1-908978-64-3 010 $a1-282-75980-9 010 $a9786612759802 010 $a1-84816-295-2 035 $a(CKB)2490000000001722 035 $a(EBL)1681672 035 $a(OCoLC)729020326 035 $a(SSID)ssj0000425148 035 $a(PQKBManifestationID)11290950 035 $a(PQKBTitleCode)TC0000425148 035 $a(PQKBWorkID)10476595 035 $a(PQKB)11034952 035 $a(MiAaPQ)EBC1681672 035 $a(WSP)00000610 035 $a(Au-PeEL)EBL1681672 035 $a(CaPaEBR)ebr10422286 035 $a(CaONFJC)MIL275980 035 $a(EXLCZ)992490000000001722 100 $a20081119d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPerspectives on vasopressin$b[electronic resource] /$feditor, John Francis Laycock 210 $aLondon $cImperial College Press$dc2010 215 $a1 online resource (357 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-294-4 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Chapter 1. Introduction to Vasopressin (John Laycock); 1. Brief Historical Perspective; 2. General Development, Anatomy and Structure of the Neurohypophysial System; 3. Synthesis, Storage and Release of Neurohypophysial Hormones; 4. Vasopressin Assays; 5. Physiological Actions; 6. Receptors and Mechanisms of Action; 7. Circulation and Metabolism; 8. Control of Release of Vasopressin; 9. Clinical Aspects of Vasopressin; 10. Conclusion; Bibliography; Chapter 2. Comparative and Evolutionary Aspects of Vasopressin (Jacques Hanoune); 1. Introduction 327 $a2. Evolutionary Aspects of the Vasopressin Family3. Evolutionary Aspects of the Vasopressin Receptor Family; 4. Evolutionary Aspects of the Aquaporin Family; 5. Conclusion; Bibliography; Chapter 3. The Neurohypophysial System: Synthesis and Metabolism of Vasopressin (Jacques Hanoune); 1. Developmental Aspects of the Endocrine Hypothalamus; 2. Biosynthesis; a) Gene structure; b) Processing of the mature peptide; 3. Control of Vasopressin Secretion; a) Control by extracellular osmolality and volaemia; b) Additional factors ; 4. Extra-hypothalamic Expression of Vasopressin; a) Adrenal medulla 327 $ab) Testisc) Blood vessels and heart; d) Other organs; 5. Peripheral Degradation and Metabolic Clearance; Bibliography; Chapter 4. Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action (Jacques Hanoune); 1. Introduction: A Short Historical Survey of Vasopressin Receptors; 2. Pharmacological Characterization of the Vasopressin Receptors; 3. Biochemical Characterization of the Vasopressin Receptors; 4. Tissue Expression; a) V1a receptor; b) V1b (V3) receptor; c) V2 receptor; 5. Vasopressin Receptors and G Proteins: An Overview; 6. Structure of the Vasopressin Receptors 327 $aa) General featuresb) Modelling of vasopressin receptors; 7. Structural Basis of the Receptor-Ligand Interaction; a) Binding of agonists; b) Binding of antagonists; 8. Domains Responsible for G Protein-Coupling Selectivity; 9. Dimerization of Receptors; 10. Signalling Pathways; a) The heterotrimeric G protein; b) The cyclic AMP pathway; c) The calcium/phosphatidyl inositol pathway; d) The V2 receptor pathway; e) The V1a receptor pathway; f ) The V1b receptor pathway; g) The proteomic approach; 11. Pre- and Post-transcriptional Regulation of Vasopressin Receptor Expression 327 $a12. Downregulation of Vasopressin Receptors: Desensitization and Internalization13. Are There Other Vasopressin Receptors?; Bibliography; Chapter 5. Pharmacology of the Vasopressin Receptors (Jacques Hanoune); 1. Introduction; 2. Radio-labelled Ligands; 3. Pharmacology of the Vasopressin V1a Receptor; 4. Pharmacology of the Vasopressin V1b Receptor; 5. Pharmacology of the Vasopressin V2 Receptor; 6. Mixed Vasopressin V1a/V2 Receptor Antagonists; 7. Inter-species and Inter-organ Variability; 8. Conclusion; Bibliography; Chapter 6. Vasopressin and Its Renal Effects (John Laycock) 327 $a1. Introduction 330 $a Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotr 606 $aVasopressin 606 $aVasopressin$xPhysiological effect 608 $aElectronic books. 615 0$aVasopressin. 615 0$aVasopressin$xPhysiological effect. 676 $a612.492 701 $aLaycock$b John F$0954157 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455572103321 996 $aPerspectives on vasopressin$92158002 997 $aUNINA LEADER 03736nam 22007215 450 001 996580167403316 005 20240308181456.0 010 $a1-4875-3874-X 010 $a1-4875-3029-3 010 $a1-4875-3028-5 024 7 $a10.3138/9781487530280 035 $a(CKB)4100000010160095 035 $a(MiAaPQ)EBC6036511 035 $a(DE-B1597)540140 035 $a(OCoLC)1139890604 035 $a(DE-B1597)9781487530280 035 $a(MiAaPQ)EBC6280727 035 $a(Au-PeEL)EBL6280727 035 $a(OCoLC)1244442761 035 $a(OCoLC)1295218403 035 $a(MdBmJHUP)musev2_109094 035 $a(DE-B1597)645240 035 $a(DE-B1597)9781487538743 035 $a(EXLCZ)994100000010160095 100 $a20200526h20202020 fg 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTransformation on the Southern Ukrainian Steppe $eLetters and Papers of Johann Cornies, Volume II: 1836?1842 /$fHarvey L. Dyck, Ingrid I. Epp, John R. Staples 205 $a1st ed. 210 1$aToronto :$cUniversity of Toronto Press,$d[2020] 210 4$dİ2020 215 $a1 online resource (751 pages) 225 0 $aTsarist and Soviet Mennonite Studies 311 $a1-4875-0449-7 327 $tFrontmatter --$tContents --$tList of Maps --$tPreface --$tAcknowledgments --$tTranslator?s Note --$tIntroduction --$t1836 --$t1837 --$t1838 --$t1839 --$t1840 --$t1841 --$t1842 --$tEditors? Introduction --$tReports --$tAppendix I: Genealogy of Johann Cornies? Immediate Family --$tAppendix II: List of Correspondents --$tAppendix III: Glossary --$tAppendix IV: Chronology --$tIndex 330 $aIn the eighteenth and nineteenth centuries, the Russian empire opened the grasslands of southern Ukraine to agricultural settlement. Among the immigrants who arrived were communities of Prussian Mennonites, recruited as "model colonists" to bring progressive agricultural methods to the east. Transformation on the Southern Ukrainian Steppe documents the Tsarist Mennonite experience through the papers of Johann Cornies (1789?1848), an ambitious and energetic leader of the Mennonite colony of Molochna. Cornies was well connected in the imperial government, and his papers offer a window not just into the world of the Molochna Mennonites, but also into the Tsarist state?s relationship with the national minorities of the frontier: Mennonites, Doukhobors, Nogai Tatars, and Jews. This selection of his letters and reports, translated into English, is an invaluable resource for scholars of all aspects of life in Tsarist Ukraine and for those interested in Mennonite history. 410 0$aTsarist and Soviet Mennonite Studies 606 $aGermans$zUkraine, Southern$vCorrespondence 610 $aJohann Cornies. 610 $aMennonite history. 610 $aPrussian Mennonites. 610 $aTsarist Mennonites. 610 $aUkraine. 610 $aUkrainian steppe. 610 $aagricultural settlement. 610 $agrasslands of southern Ukraine. 610 $ahistory of Ukraine. 610 $aletters. 615 0$aGermans 676 $a305.8310477 702 $aDyck$b Harvey L.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aEpp$b Ingrid I.$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aStaples$b John R.$4edt$4http://id.loc.gov/vocabulary/relators/edt 712 02$aUniversity of Toronto.$bLibrary,$4fnd$4http://id.loc.gov/vocabulary/relators/fnd 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a996580167403316 996 $aTransformation on the Southern Ukrainian steppe$92627552 997 $aUNISA