LEADER 04045nam 22007575 450 001 996547956503316 005 20230810180808.0 010 $a9783031213915$b(electronic bk.) 010 $z9783031213908 024 7 $a10.1007/978-3-031-21391-5 035 $a(MiAaPQ)EBC30545029 035 $a(Au-PeEL)EBL30545029 035 $a(OCoLC)1379437660 035 $a(DE-He213)978-3-031-21391-5 035 $a(BIP)085993125 035 $a(PPN)270617914 035 $a(EXLCZ)9926707048800041 100 $a20230515d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBioinformatic and Statistical Analysis of Microbiome Data$b[electronic resource] $eFrom Raw Sequences to Advanced Modeling with QIIME 2 and R /$fby Yinglin Xia, Jun Sun 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (716 pages) 311 08$aPrint version: Xia, Yinglin Bioinformatic and Statistical Analysis of Microbiome Data Cham : Springer International Publishing AG,c2023 9783031213908 320 $aIncludes bibliographical references and index. 327 $aChapter 1. Introduction to Linux and Unix -- Chapter 2. Introduction to R, Rstudio -- Chapter 3. Bioinformatic Analysis of Next-Generation Sequencing -- Chapter 4. Bioinformatic Analysis of Metagenomics -- Chapter 5. Alpha Diversity -- Chapter 6. Beta Diversity -- Chapter 7. Differential Abundance Analysis -- Chapter 8. Analyzing Zero-Inflated Microbiome Data -- Chapter 9. Compositional Analysis of Microbiome Data -- Chapter 10. Longitudinal Data Analysis of Microbiome -- Chapter 11. Meta-analysis of Microbiome Data (optional). 330 $aThis unique book addresses the bioinformatic and statistical modelling and also the analysis of microbiome data using cutting-edge QIIME 2 and R software. It covers core analysis topics in both bioinformatics and statistics, which provides a complete workflow for microbiome data analysis: from raw sequencing reads to community analysis and statistical hypothesis testing. It includes real-world data from the authors? research and from the public domain, and discusses the implementation of QIIME 2 and R for data analysis step-by-step. The data as well as QIIME 2 and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter so that these new methods can be readily applied in their own research. Bioinformatic and Statistical Analysis of Microbiome Data is an ideal book for advanced graduate students and researchers in the clinical, biomedical, agricultural, and environmental fields, as well as those studying bioinformatics, statistics, and big data analysis. 606 $aBioinformatics 606 $aBiometry 606 $aBig data 606 $aMathematical statistics$xData processing 606 $aBiotechnology 606 $aBiomedical engineering 606 $aBioinformatics 606 $aBiostatistics 606 $aBig Data 606 $aStatistics and Computing 606 $aBiotechnology 606 $aBiomedical Engineering and Bioengineering 610 $aMicrobiology 610 $aScience 615 0$aBioinformatics. 615 0$aBiometry. 615 0$aBig data. 615 0$aMathematical statistics$xData processing. 615 0$aBiotechnology. 615 0$aBiomedical engineering. 615 14$aBioinformatics. 615 24$aBiostatistics. 615 24$aBig Data. 615 24$aStatistics and Computing. 615 24$aBiotechnology. 615 24$aBiomedical Engineering and Bioengineering. 676 $a576 700 $aXia$b Yinglin$0767992 702 $aSun$b Jun 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a996547956503316 996 $aBioinformatic and Statistical Analysis of Microbiome Data$93430601 997 $aUNISA