LEADER 05428nam 2200649 450 001 9910465054303321 005 20191016115245.0 010 $a1-908230-98-3 035 $a(CKB)3710000000083273 035 $a(EBL)1909042 035 $a(SSID)ssj0001154051 035 $a(PQKBManifestationID)11719222 035 $a(PQKBTitleCode)TC0001154051 035 $a(PQKBWorkID)11154191 035 $a(PQKB)10544179 035 $a(MiAaPQ)EBC1909042 035 $a(MiAaPQ)EBC5897856 035 $a(Au-PeEL)EBL5897856 035 $a(OCoLC)874146835 035 $a(EXLCZ)993710000000083273 100 $a20191016d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCampylobacter ecology and evolution /$fedited by Samuel K. Sheppard ; associate editor, Guillaume Me?ric 210 1$aNorfolk, England :$cCaister Academic Press,$d[2014] 210 4$dİ2014 215 $a1 online resource (377 p.) 300 $a"Medical microbiology and infectious diseases, Swansea University, Swansea UK." 311 $a1-908230-36-3 320 $aIncludes bibliographical references and index. 327 $aContents; Current books of interest; Contributors; Foreword; Preface; Part I: Mechanisms of Evolution; 1: A Candidate Hopeful Monster in the Genus Campylobacter; Introduction; Hybridization by horizontal gene transfer; 2: Learning About Recombination in Campylobacter; Introduction; Estimating recombination from population data; Estimating recombination from closely related isolates; Discussion; 3: Within-host Evolution of Campylobacter jejuni; Introduction; Phenotypic changes of Campylobacter jejuni after host passage; Genotypic changes of Campylobacter jejuni during host passage; Conclusions 327 $aFuture studies4: Concerted Evolution in Campylobacter jejuni and Campylobacter coli; Concerted evolution; Duplicated genes in Campylobacter; Unresolved questions; 5: Genome and Transcriptome Evolution in the Genus Campylobacter; Introduction; Characteristics of Campylobacter genome sequences; Transcriptome evolution in the genus Campylobacter; Conclusions; 6: Repetitive DNA: A Major Source of Genetic Diversity in Campylobacter Populations?; Introduction; Types, prevalence and mutability of SSRs in Campylobacter genomes; Variation in SSRs has functionally important phenotypic effects 327 $aCombinatorial consequences of multiple phase-variable genesInfluence of mutational, selective and population forces on the diversity of phase-variable genotypes; Modelling phase-variable genes and selection for mutational rates; Experimental issues connected with phase variation; Summary; Future perspectives; Part II: Adaptations to Host Colonization; 7: Campylobacter Strategies for Colonizing the Host Gastrointestinal Tract; Introduction; Carbon sources utilized by Campylobacter to support growth in vivo; Mucins and the mucous layer; Conclusions and future trends 327 $a8: The Intricate Relationship Between Campylobacter and MucusThe stucture and function of intestinal mucus; The ecology of C. jejuni in intestinal mucus; Mucus as a source of glycans; Campylobacter jejuni commensalism in chickens; Conclusions and future directions; 9: Campylobacter Association with the Human Host; Introduction; Adhesion, invasion and translocation; Bacterial factors influencing adhesion and invasion of C. jejuni; Do all campylobacters invade to the same extent?; Conclusion; 10: Siderophore-mediated Iron Acquisition for Campylobacter Infection; Introduction 327 $aIron sources in the intestine: an ecological viewEnterobactin-mediated iron acquisition; Salmochelin-mediated iron acquisition; Hydroxamate siderophore-mediated iron acquisition; Conclusion and future directions; 11: Genetic Mechanisms Involved in Campylobacter jejuni Survival Under Oxidative Stress Conditions; The C. jejuni survival conundrum; Oxidative stress overview; C. jejuni mechanisms for countering oxidative stress; Oxidative stress regulation in C. jejuni; Discussion and future perspectives; 12: Oxidative Stress Survival During Campylobacter Transmission and Infection 327 $aCampylobacter jejuni transmission and aerotolerance 330 $aMembers of the genus Campylobacter are commonly found in the gastrointestinal tract of mammals and birds, and can be commensal or pathogenic in nature. For example, Campylobacter jejuni can be a harmless commensal organism in poultry and other avian and animal hosts, but in humans, it is pathogenic and the most common cause of bacterial gastroenteritis worldwide. 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