LEADER 01805nam 2200529 450 001 996479372003316 005 20231110222542.0 010 $a3-030-96666-6 035 $a(MiAaPQ)EBC7013167 035 $a(Au-PeEL)EBL7013167 035 $a(CKB)23524795600041 035 $aEBL7013167 035 $a(AU-PeEL)EBL7013167 035 $a(PPN)269149783 035 $a(EXLCZ)9923524795600041 100 $a20221221d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTopics in global real analytic geometry /$fFrancesca Acquistapace, Fabrizio Broglia, and Jose? F. Fernando 210 1$aCham, Switzerland :$cSpringer International Publishing,$d[2022] 210 4$d©2022 215 $a1 online resource (285 pages) 225 1 $aSpringer Monographs in Mathematics 300 $aDescription based upon print version of record. 311 08$aPrint version: Acquistapace, Francesca Topics in Global Real Analytic Geometry Cham : Springer International Publishing AG,c2022 9783030966652 410 0$aSpringer Monographs in Mathematics 606 $aGeometry, Analytic 606 $aGeometry, Analytic$xData processing 606 $aGeometria analítica$2thub 608 $aLlibres electrònics$2thub 615 0$aGeometry, Analytic. 615 0$aGeometry, Analytic$xData processing. 615 7$aGeometria analítica 676 $a516.3 700 $aAcquistapace$b Francesca$041866 702 $aBroglia$b Fabrizio$f1948- 702 $aFernando$b Jose? F. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996479372003316 996 $aTopics in global real analytic geometry$92997448 997 $aUNISA LEADER 04035nam 22006975 450 001 9910298587703321 005 20200630233357.0 010 $a3-319-45384-X 024 7 $a10.1007/978-3-319-45384-2 035 $a(CKB)4100000000587586 035 $a(DE-He213)978-3-319-45384-2 035 $a(MiAaPQ)EBC5061637 035 $a(PPN)20453125X 035 $a(EXLCZ)994100000000587586 100 $a20170927d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLabel-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors /$fby Maximilian Oberleitner 205 $a1st ed. 2018. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2018. 215 $a1 online resource (XXVI, 370 p. 138 illus., 122 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-319-45383-1 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction -- Objectives -- Methods & Instrumentation -- MQCM: Multiple Cytomechanic Sensing -- QCM-ECIS: Combined Viscoelastic and Dielectric Sensing of Cells -- QCM-OCS: Optochemical Sensing of Temperature and pO2 in the Cell Surface Junction -- Summary -- Appendix. 330 $aThis thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aAnalytical chemistry 606 $aNanochemistry 606 $aDiagnosis, Laboratory 606 $aCell culture 606 $aBiophysics 606 $aBiophysics 606 $aAnalytical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C11006 606 $aNanochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C33000 606 $aLaboratory Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B15007 606 $aCell Culture$3https://scigraph.springernature.com/ontologies/product-market-codes/L16020 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 615 0$aAnalytical chemistry. 615 0$aNanochemistry. 615 0$aDiagnosis, Laboratory. 615 0$aCell culture. 615 0$aBiophysics. 615 0$aBiophysics. 615 14$aAnalytical Chemistry. 615 24$aNanochemistry. 615 24$aLaboratory Medicine. 615 24$aCell Culture. 615 24$aBiological and Medical Physics, Biophysics. 676 $a610.28 700 $aOberleitner$b Maximilian$4aut$4http://id.loc.gov/vocabulary/relators/aut$0768468 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298587703321 996 $aLabel-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors$91565448 997 $aUNINA