LEADER 05599nam 2200697Ia 450 001 9910465409103321 005 20200520144314.0 010 $a1-283-54898-4 010 $a9786613861436 010 $a90-272-7349-9 035 $a(CKB)2560000000091091 035 $a(EBL)997710 035 $a(OCoLC)810533780 035 $a(SSID)ssj0000701613 035 $a(PQKBManifestationID)12263513 035 $a(PQKBTitleCode)TC0000701613 035 $a(PQKBWorkID)10672452 035 $a(PQKB)10740891 035 $a(MiAaPQ)EBC997710 035 $a(Au-PeEL)EBL997710 035 $a(CaPaEBR)ebr10593808 035 $a(CaONFJC)MIL386143 035 $a(EXLCZ)992560000000091091 100 $a20120521d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMultilingual individuals and multilingual societies$b[electronic resource] /$fedited by Kurt Braunmu?ller, Christoph Gabriel 210 $aAmsterdam ;$aPhiladelphia $cJohn Benjamins Pub. Co.$d2012 215 $a1 online resource (490 p.) 225 0 $aHamburg studies on multilingualism (HSM) ;$v13 300 $aDescription based upon print version of record. 311 $a90-272-1933-8 320 $aIncludes bibliographical references and index. 327 $aMultilingual Individuals and Multilingual Societies; Editorial page; Title page; LCC data; Acknowledgement; Table of contents; Foreword; References; Part I. How language is acquired and lost in multilingual settings; Case marking in child L1 and early child L2 German; 1. Introduction; 2. The German case system; 2.1 Case forms in German; 2.2 Structural case vs. lexical case; 3. The acquisition of case in German; 3.1 An overview; 3.2 The study by Eisenbeiss et al. (2006): Case marking by monolingual German children; 3.3 The criteria used by Eisenbeiss et al. in their analysis of case 327 $a4. Spontaneous production data from successive bilingual children with L1 Turkish 5. Experimental data from monolingual and successive bilingual children; 6. Discussion; 7. Conclusions; References; First exposure learners make use of top-down lexical knowledge when learning words; 1. Experience and L1 knowledge in L2 word learning; 2. Segmenting sound forms, recognizing words and making form-meaning correspondences; 3. Why study first exposure learners?; 4. Our studies; 4.1 Methodology and stimuli; 4.2 Participants; 4.3 Results; 5. Discussion and conclusions; References; Wh-questions in Dutch 327 $a1. Introduction 2. Cross-linguistic influence in multilingual acquisition; 3. Wh-questions in Dutch, French and Italian; 3.1 Syntax of wh-questions in Dutch, French and Italian; 3.2 Monolingual acquisition of wh-questions in Dutch, French and Italian; 3.3 Multilingual acquisition of wh-questions; 4. Study; 4.1 Hypotheses; 4.2 Participants; 4.3 Experimental task; 4.4 Results; 5. Discussion and conclusions; References; The emergence of a new variety of Russian in a language contact situation; 1. Background; 1.1 The subject of the study; 1.2 Why negation?; 1.3 The functions of negation 327 $a1.4 Negation in Russian 1.5 Negation in Swedish; 2. Negation in Julia's data; 2.1 Pre-verbal negation: Gestures; 2.2 Verbal negation; 3. Discussion; 4. Conclusion; References; The acquisition of gender agreement marking in Polish; 1. Introduction; 2. Gender classes, gender agreement and gender assignment in Polish; 3. State of the art; 3.1 The acquisition of gender in Polish; 3.2 The acquisition of gender in bilingual children; 4. Design of the present study; 4.1 Participants; 4.2 Methods; 5. Results; 5.1 Correlation of age and correctness 327 $a5.2 Correctness of gender markings with typical, atypical and nonce nouns 5.3 Error analyses; 6. General discussion and conclusion; References; Discourse cohesion in the elicited narratives of early Russian-German sequential bilinguals; 1. Introduction; 1.1 Discourse cohesion and coherence in narratives; 1.2 Some facts about the acquisition of Russian; 2. Method; 3. Results and discussion; 4. Conclusion; Appendix; References; German segments in the speech of German-Spanish bilingual children; 1. Introduction; 2. The German voicing contrast; 2.1 Theoretical description and acquisition 327 $a2.2 The study 330 $aThe 25 contributions of this volume represent a selection from the more than 120 papers originally presented at the International Conference on "Multilingual Individuals and Multilingual Societies" (MIMS), held in Hamburg (October 2010) and organized by the Collaborative Research Center "Multilingualism" after twelve years of successful research. It presents a panorama of contemporary research in multilingualism covering three fields of investigation: (1) the simultaneous and successive acquisition of more than one language, including language attrition in multilingual settings, (2) historical 410 0$aHamburg Studies on Multilingualism 606 $aMultilingualism$xSocial aspects 606 $aLanguages in contact 606 $aSociolinguistics 608 $aElectronic books. 615 0$aMultilingualism$xSocial aspects. 615 0$aLanguages in contact. 615 0$aSociolinguistics. 676 $a306.44/6 701 $aBraunmu?ller$b Kurt$f1948-$0422651 701 $aGabriel$b Christoph$0905681 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910465409103321 996 $aMultilingual individuals and multilingual societies$92025817 997 $aUNINA LEADER 04727nam 22007935 450 001 996466346603316 005 20200701050946.0 010 $a3-540-45352-0 024 7 $a10.1007/3-540-45352-0 035 $a(CKB)1000000000211327 035 $a(SSID)ssj0000323240 035 $a(PQKBManifestationID)11223086 035 $a(PQKBTitleCode)TC0000323240 035 $a(PQKBWorkID)10312546 035 $a(PQKB)10717802 035 $a(DE-He213)978-3-540-45352-9 035 $a(MiAaPQ)EBC3072071 035 $a(PPN)155203673 035 $a(EXLCZ)991000000000211327 100 $a20121227d2000 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFormal Techniques in Real-Time and Fault-Tolerant Systems$b[electronic resource] $e6th International Symposium, FTRTFT 2000 Pune, India, September 20-22, 2000 Proceedings /$fedited by Mathai Joseph 205 $a1st ed. 2000. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2000. 215 $a1 online resource (X, 314 p.) 225 1 $aLecture Notes in Computer Science,$x0302-9743 ;$v1926 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a3-540-41055-4 320 $aIncludes bibliographical references and index. 327 $aInvited Lectures -- Stability of Discrete Sampled Systems -- Issues in the Refinement of Distributed Programs -- Challenges in the Verification of Electronic Control Units -- Model Checking -- Scaling up Uppaal -- Decidable Model Checking of Probabilistic Hybrid Automata -- Fault Tolerance -- Invariant-Based Synthesis of Fault-Tolerant Systems -- Modeling Faults of Distributed, Reactive Systems -- Threshold and Bounded-Delay Voting in Critical Control Systems -- Automating the Addition of Fault-Tolerance -- Reliability Modelling of Time-Critical Distributed Systems -- Scheduling -- A Methodology for the Construction of Scheduled Systems -- A Dual Interpretation of ?Standard Constraints? in Parametric Scheduling -- Validation -- Co-Simulation of Hybrid Systems: Signal-Simulink -- A System for Object Code Validation -- Refinement -- Real-Time Program Refinement Using Auxiliary Variables -- On Refinement and Temporal Annotations -- Generalizing Action Systems to Hybrid Systems -- Verification -- Compositional Verification of Synchronous Networks -- Modelling Coordinated Atomic Actions in Timed CSP -- Logic and Automata -- A Logical Characterisation of Event Recording Automata -- Using Cylindrical Algebraic Decomposition for the Analysis of Slope Parametric Hybrid Automata -- Probabilistic Neighbourhood Logic -- An On-the-Fly Tableau Construction for a Real-Time Temporal Logic -- Verifying Universal Properties of Parameterized Networks. 410 0$aLecture Notes in Computer Science,$x0302-9743 ;$v1926 606 $aProgramming languages (Electronic computers) 606 $aArchitecture, Computer 606 $aComputer logic 606 $aMicroprocessors 606 $aSpecial purpose computers 606 $aLogic design 606 $aProgramming Languages, Compilers, Interpreters$3https://scigraph.springernature.com/ontologies/product-market-codes/I14037 606 $aComputer System Implementation$3https://scigraph.springernature.com/ontologies/product-market-codes/I13057 606 $aLogics and Meanings of Programs$3https://scigraph.springernature.com/ontologies/product-market-codes/I1603X 606 $aProcessor Architectures$3https://scigraph.springernature.com/ontologies/product-market-codes/I13014 606 $aSpecial Purpose and Application-Based Systems$3https://scigraph.springernature.com/ontologies/product-market-codes/I13030 606 $aLogic Design$3https://scigraph.springernature.com/ontologies/product-market-codes/I12050 615 0$aProgramming languages (Electronic computers). 615 0$aArchitecture, Computer. 615 0$aComputer logic. 615 0$aMicroprocessors. 615 0$aSpecial purpose computers. 615 0$aLogic design. 615 14$aProgramming Languages, Compilers, Interpreters. 615 24$aComputer System Implementation. 615 24$aLogics and Meanings of Programs. 615 24$aProcessor Architectures. 615 24$aSpecial Purpose and Application-Based Systems. 615 24$aLogic Design. 676 $a004/.33 702 $aJoseph$b Mathai$4edt$4http://id.loc.gov/vocabulary/relators/edt 712 12$aFTRTFT 2000 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996466346603316 996 $aFormal Techniques in Real-Time and Fault-Tolerant Systems$91944996 997 $aUNISA LEADER 01927nam 22004333 450 001 9910784395003321 005 20230913164657.0 010 $a1-60129-002-0 035 $a(CKB)1000000000346104 035 $a(EBL)257182 035 $a(OCoLC)191037853 035 $a(MiAaPQ)EBC257182 035 $a(EXLCZ)991000000000346104 100 $a20130418d2001|||| uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTaking charge $ea bipartisan report to the president-elect on foreign policy and national security /$fTransition 2001, Frank Carlucci, Robert E. Hunter, Zalmay Khalilzad, co-chairs 210 1$aSanta Monica, CA :$cRAND Corporation,$d2001. 215 $a1 online resource (xvii, 74 pages) 311 0 $a0-8330-2957-6 327 $aPreface; Transmittal Letter to the President-Elect; Chapter One: Introduction: Setting Directions for the Global Era; Chapter Two: First Steps: The Transition and After Inauguration; Chapter Three: Setting the Stage: Longer-Term Issues; Appendix: Comments and Dissent by Transition 2001 Panel Members 330 $aA collection of discussion papers, prepared by RAND staff and others, that analyze the most critical foreign and national security issues facing the United States, both during the early days of the Bush administration and in the long term. 606 $aUnited States - Foreign relations - 1993-2001 615 4$aUnited States - Foreign relations - 1993-2001. 676 $a327.73 676 $a355.0310973 700 $aCarlucci$b Frank Charles$f1930-2018.$01491030 701 $aHunter$b Robert= Edwards$f1940-$0935276 701 $aKhalilzad$b Zalmay$0912693 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910784395003321 996 $aTaking charge$93712568 997 $aUNINA LEADER 05440nam 22006974a 450 001 9910830389103321 005 20170815120509.0 010 $a1-280-40909-6 010 $a9786610409099 010 $a0-470-36036-4 010 $a0-471-73934-0 010 $a0-471-73933-2 035 $a(CKB)1000000000355493 035 $a(EBL)255368 035 $a(OCoLC)304135693 035 $a(SSID)ssj0000200618 035 $a(PQKBManifestationID)11203208 035 $a(PQKBTitleCode)TC0000200618 035 $a(PQKBWorkID)10220744 035 $a(PQKB)10769368 035 $a(MiAaPQ)EBC255368 035 $a(PPN)24326576X 035 $a(EXLCZ)991000000000355493 100 $a20060119d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMedicinal chemistry of bioactive natural products$b[electronic resource] /$fedited by Xiao-Tian Liang, Wei-Shuo Fang 210 $aHoboken, N.J. $cWiley-Interscience/John Wiley$dc2006 215 $a1 online resource (482 p.) 300 $aDescription based upon print version of record. 311 $a0-471-66007-8 320 $aIncludes bibliographical references and index. 327 $aMEDICINAL CHEMISTRY OF BIOACTIVE NATURAL PRODUCTS; CONTENTS; Preface; Contributors; 1 The Chemistry and Biology of Epothilones-Lead Structures for the Discovery of Improved Microtubule Inhibitors; 1.1. Introduction; 1.2. Biological Effects of Epo B; 1.2.1 In Vitro Activity; 1.2.2 In Vivo Antitumor Activity; 1.3. Epothilone Analogs and SAR Studies; 1.3.1 Lactam-Based Analogs; 1.3.2 Modifications in the C9-C11 Region; 1.3.3 Modifications of the Epoxide Moiety; 1.3.4 C-26-Modified Analogs; 1.3.5 Side-Chain Modifications; 1.3.6 Aza-Epothilones 327 $a1.4. Pharmacophore Modeling and Conformational Studies1.5. Epothilone Analogs in Clinical Development; 1.6. Conclusions; Acknowledgments; References; 2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives; 2.1. Introduction; 2.2. Classification of Glycopeptide Antibiotics; 2.3. Mode of Action; 2.4. Glycopeptide Resistance; 2.5. Biosynthesis; 2.6. Total Synthesis; 2.7. Glycopeptides as Chiral Selectors in Chromatography and Capillary Electrophoresis; 2.8. Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship (SAR) Studies 327 $a2.8.1 Modifications of Glycopeptide Antibiotics2.8.2 Rational Concepts for the Design of Novel Glycopeptides; 2.8.3 Conclusions; Acknowledgment; References; 3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs; 3.1. Discovery and Research and Development of Taxol; 3.2. Paclitaxel Analogs Active Against Normal Tumor Cells; 3.2.1 C-13 Side Chain; 3.2.2 A Ring and Its Substitutions; 3.2.3 B Ring and Its Substitutions; 3.2.4 C Ring and Its Substitutions; 3.2.5 D Ring; 3.2.6 Macrocyclic Analogs; 3.2.7 Miscellaneous 327 $a3.3. Exploration on Mechanism of Paclitaxel Related to Tubulin Binding and Quest for Its Pharmacophore3.3.1 Biochemical Mechanism of Paclitaxel Related to Tubulin Binding; 3.3.2 Identification of Bioactive Conformations and Quest for a Pharmacophore for Paclitaxel; 3.4. Natural and Semisynthetic Taxoids Overcoming Multidrug Resistance (MDR); 3.4.1 Structure-Modified Taxoids With Better Activity Toward MDR Tumors; 3.4.2 Nonpaclitaxel-Type Taxoids With MDR Reversal Activities; 3.4.3 Factors Contributing to the Resistance to Paclitaxel 327 $a3.5 Design, Synthesis and Pharmacological Activity of Prodrugs of Paclitaxel3.5.1 Prodrugs Prepared to Improve Water Solubility; 3.5.2 Prodrugs Designed for Enhancing Specificity; 3.6 Other Biological Actions of Paclitaxel; 3.7 New Antimicrotubule Molecules Mimicking Action of Paclitaxel; 3.8 Conclusion; Acknowledgments; References; 4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer's Disease; 4.1 Introduction; 4.1.1 Powerful AChEI Originated From Traditional Chinese Medicine; 4.1.2 Alzheimer's Disease; 4.2. Profiles of HA; 4.2.1 Discovery of HA 327 $a4.2.2 Physical Appearance of HA 330 $aCurrent discoveries and research into bioactive natural productsMedicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current rese 606 $aMateria medica, Vegetable 606 $aPharmaceutical chemistry 606 $aNatural products 606 $aBioactive compounds 615 0$aMateria medica, Vegetable. 615 0$aPharmaceutical chemistry. 615 0$aNatural products. 615 0$aBioactive compounds. 676 $a615.321 676 $a615/.321 701 $aLiang$b Xiaotian$01680945 701 $aFang$b Wei-Shuo$01680946 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830389103321 996 $aMedicinal chemistry of bioactive natural products$94050011 997 $aUNINA