LEADER 06669nam 2200517 450 001 996464531703316 005 20220820133720.0 010 $a3-030-91814-9 035 $a(MiAaPQ)EBC6810927 035 $a(Au-PeEL)EBL6810927 035 $a(CKB)19919642600041 035 $a(OCoLC)1286660273 035 $a(PPN)258838876 035 $a(EXLCZ)9919919642600041 100 $a20220820d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvances in bioinformatics and computational biology $e14th Brazilian Symposium on Bioinformatics, BSB 2021, virtual event, November 22-26, 2021, proceedings /$fPeter F. Stadler [and three others], editors 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (159 pages) 225 1 $aLecture notes in computer science, lecture notes in bioinformatics ;$vVolume 13063 311 08$aPrint version: Stadler, Peter F. Advances in Bioinformatics and Computational Biology Cham : Springer International Publishing AG,c2021 9783030918132 320 $aIncludes bibliographical references and index. 327 $aIntro -- Preface -- Organization -- Contents -- Applied Bioinformatics and Computational Biology -- Comparative Transcriptome Profiling of Maytenus ilicifolia Root and Leaf -- 1 Introduction -- 2 Methods -- 2.1 Plant Material and Total RNA Isolation -- 2.2 Library Preparation and Sequencing -- 2.3 Quality Control and de novo Assembly -- 2.4 Functional Annotation -- 2.5 Differential Expression Analysis -- 2.6 Gene Ontology Enrichment and KEGG Analysis -- 3 Results and Discussion -- 3.1 De novo Assembly and Functional Annotation of M. ilicifolia -- 3.2 Identification of Differentially Expressed Transcripts in Both Tissues -- References -- Hypusine Plays a Role in the Translation of Short mRNAs and Mediates the Polyamine and Autophagy Pathways in Saccharomyces Cerevisiae -- 1 Introduction -- 2 Materials and Methods -- 2.1 RNA-seq Data Analysis -- 2.2 Strain and Growth Conditions -- 2.3 RNA Isolation and qRT-PCR -- 2.4 Protein Extraction and Western Blot Analysis -- 3 Results and Discussion -- 3.1 Translation of Short ORFs is Impaired in dys1-1 Mutant -- 3.2 Hypusination Modulates Autophagy -- References -- Topological Characterization of Cancer Driver Genes Using Reactome Super Pathways Networks -- 1 Introduction -- 2 Method -- 2.1 Reactome Functional Iteration -- 2.2 Super Pathways as Reactome FI Sub-networks -- 2.3 Super Pathways Sub-networks Enriched with Drivers Information -- 3 Results -- 3.1 Centrality Measures -- 3.2 Network Attack -- 4 Discussion and Conclusion -- References -- Bioinformatics and Computational Biology -- CellHeap: A Workflow for Optimizing COVID-19 Single-Cell RNA-Seq Data Processing in the Santos Dumont Supercomputer -- 1 Introduction -- 2 Description of the CellHeap Workflow -- 3 Results -- 3.1 Input Data and Experiment Setup -- 3.2 Environmental Setup -- 3.3 Results Discussion -- 4 Conclusion -- References. 327 $aCombining Orthology and Xenology Data in a Common Phylogenetic Tree -- 1 Introduction -- 2 Preliminaries -- 3 Tree-Like Pairs of Maps -- 4 Tree-Like Pairs of Maps with Constraints -- 5 Concluding Remark -- References -- ContFree-NGS: Removing Reads from Contaminating Organisms in Next Generation Sequencing Data -- 1 Introduction -- 2 Implementation -- 3 Evaluation -- 4 Conclusion -- References -- Deep Learning-Based COVID-19 Diagnostics of Low-Quality CT Images -- 1 Introduction -- 2 Dataset -- 3 Methodology -- 3.1 Data Preprocessing -- 3.2 Deep Neural Network Architectures -- 4 Experimental Evaluation -- 4.1 Data Preprocessing -- 4.2 Transfer Learning with ResNet50 -- 4.3 Image- and Exam-Level Classification of the Test Set -- 4.4 Interpreting Model Decisions -- 5 Conclusion -- References -- Feature Importance Analysis of Non-coding DNA/RNA Sequences Based on Machine Learning Approaches -- 1 Background -- 2 Pipeline for Machine Learning Classification Task -- 2.1 Prediction of sRNAs -- 2.2 Prediction of CircRNA -- 3 Results and Discussion -- 3.1 Case Study 1: sRNAs in Bacteria -- 3.2 Case Study 2: CircRNA in Humans -- 4 Conclusion -- References -- Heuristics for Cycle Packing of Adjacency Graphs for Genomes with Repeated Genes -- 1 Introduction -- 2 Definitions -- 3 Random Packings -- 4 Genetic Algorithm -- 5 Experimental Results -- 5.1 Applications with the Reversal Distance -- 5.2 Experiments with Real Biological Data -- 6 Conclusion -- References -- PIMBA: A PIpeline for MetaBarcoding Analysis -- 1 Introduction -- 2 Implementation -- 2.1 Preprocessing -- 2.2 Taxonomy Assignment -- 2.3 Plotting -- 3 Results and Discussion -- 3.1 16S rRNA Mock Community -- 3.2 Fungal ITS Mock Community -- 3.3 Metazoan COI Mock Community -- 4 Conclusion -- References -- Short Papers -- CEvADA: Co-Evolution Analysis Data Archive -- 1 Introduction -- 2 Technical Notes. 327 $aReferences -- FluxPRT: An Adaptable and Extensible Proteomics LIMS -- 1 Introduction -- 2 Proteomics Lab Operations -- 3 Methodology -- 3.1 Proteomics Workflow Construction and the Flux LIMS -- 3.2 Proteomics Guide -- 4 Results and Discussion -- 4.1 FluxPRT Workflow -- 4.2 Proteomics Guide -- 4.3 FluxPRT Interface -- 5 Concluding Remarks -- 6 Availability -- References -- MathPIP: Classification of Proinflammatory Peptides Using Mathematical Descriptors -- 1 Background -- 2 Materials and Methods -- 2.1 Data Selection -- 2.2 Feature Engineering -- 2.3 Experimental Setting -- 3 Results and Discussion -- 4 Conclusion -- References -- Metagenomic Insights of the Microbial Community from a Polluted River in Brazil 2020 -- 1 Introduction -- 2 Materials and Methods -- 3 Results -- 4 Conclusion -- References -- Mesoscopic Evaluation of DNA Mismatches in PCR Primer-Target Hybridisation to Detect SARS-CoV-2 Variants of Concern -- 1 Introduction -- 2 Materials and Methods -- 3 Results and Discussion -- 4 Conclusion -- References -- Author Index. 410 0$aLecture notes in computer science.$pLecture notes in bioinformatics ;$vVolume 13063. 606 $aBioinformatics$vCongresses 606 $aComputational biology$vCongresses 606 $aBioinformatics 615 0$aBioinformatics 615 0$aComputational biology 615 0$aBioinformatics. 676 $a572.80285 702 $aStadler$b Peter F.$f1965- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996464531703316 996 $aAdvances in Bioinformatics and Computational Biology$92998120 997 $aUNISA LEADER 03775nam 22007695 450 001 9910257394003321 005 20250801064818.0 010 $a3-540-69650-4 024 7 $a10.1007/3-540-69650-4 035 $a(CKB)1000000000778102 035 $a(SSID)ssj0000323444 035 $a(PQKBManifestationID)12117804 035 $a(PQKBTitleCode)TC0000323444 035 $a(PQKBWorkID)10300012 035 $a(PQKB)10762044 035 $a(DE-He213)978-3-540-69650-6 035 $a(MiAaPQ)EBC3071716 035 $a(MiAaPQ)EBC6486171 035 $a(PPN)155223348 035 $a(EXLCZ)991000000000778102 100 $a20121227d1997 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aGenerating Families in the Restricted Three-Body Problem /$fby Michel Henon 205 $a1st ed. 1997. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d1997. 215 $a1 online resource (XI, 280 p.) 225 1 $aLecture Notes in Physics Monographs ;$v52 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-662-14156-6 311 08$a3-540-63802-4 320 $aIncludes bibliographical references and index. 327 $aDefinitions and Properties -- Generating Orbits of the First Species -- Generating Orbits of the Second Species -- Generating Orbits of the Third Species -- Bifurcation Orbits -- Junctions: Symmetry -- Junctions: Broucke?s Principle -- Fragments -- Generating Families. 330 $aThe classical restricted problem of three bodies is of fundamental importance for its applications to astronomy and space navigation, and also as a simple model of a non-integrable Hamiltonian dynamical system. A central role is played by periodic orbits, of which a large number have been computed numerically. In this book an attempt is made to explain and organize this material through a systematic study of generating families, which are the limits of families of periodic orbits when the mass ratio of the two main bodies becomes vanishingly small. The most critical part is the study of bifurcations, where several families come together and it is necessary to determine how individual branches are joined. Many different cases must be distinguished and studied separately. Detailed recipes are given. Their use is illustrated by determining a number of generating families, associated with natural families of the restricted problem, and comparing them with numerical computations in the Earth-Moon and Sun-Jupiter case. 410 0$aLecture Notes in Physics Monographs ;$v52 606 $aAstronomy$vObservations 606 $aSystem theory 606 $aMathematics$xData processing 606 $aSolar system 606 $aMathematical physics 606 $aAstronomy, Observations and Techniques 606 $aComplex Systems 606 $aComputational Mathematics and Numerical Analysis 606 $aSpace Physics 606 $aTheoretical, Mathematical and Computational Physics 615 0$aAstronomy 615 0$aSystem theory. 615 0$aMathematics$xData processing. 615 0$aSolar system. 615 0$aMathematical physics. 615 14$aAstronomy, Observations and Techniques. 615 24$aComplex Systems. 615 24$aComputational Mathematics and Numerical Analysis. 615 24$aSpace Physics. 615 24$aTheoretical, Mathematical and Computational Physics. 676 $a521 700 $aHenon$b Michel$f1931-$061600 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910257394003321 996 $aGenerating Families in the Restricted Three-Body Problem$9375360 997 $aUNINA