LEADER 05397nam 22006494a 450 001 9910146077703321 005 20170815112645.0 010 $a1-280-54191-1 010 $a9786610541911 010 $a0-471-57770-7 010 $a0-471-57890-8 035 $a(CKB)1000000000019125 035 $a(EBL)210517 035 $a(OCoLC)637310181 035 $a(SSID)ssj0000310914 035 $a(PQKBManifestationID)11239037 035 $a(PQKBTitleCode)TC0000310914 035 $a(PQKBWorkID)10313035 035 $a(PQKB)11632076 035 $a(MiAaPQ)EBC210517 035 $a(EXLCZ)991000000000019125 100 $a20030922d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSynthetic multivalent molecules$b[electronic resource] $econcepts and biomedical applications /$fSeok-ki Choi 210 $aHoboken, N.J. $cWiley$dc2004 215 $a1 online resource (446 p.) 300 $aDescription based upon print version of record. 311 $a0-471-56347-1 320 $aIncludes bibliographical references and index. 327 $aSYNTHETIC MULTIVALENT MOLECULES; CONTENTS; Preface; Notes for Organization and Classification; Abbreviations; 1 Introduction; 1.1 Nomenclature and Definitions; 1.1.1 Valency; 1.1.2 Linkers; 1.1.3 Scaffolds; 1.1.4 Ligand Density; 1.1.5 Homo- and Heterovalent Molecules; 1.2 Mechanistic Aspects of Multivalent Interaction; 1.2.1 Affinity Constant and Avidity; 1.2.2 Thermodynamics; 1.2.3 Kinetics; 1.2.4 Steric Effects; 1.3 Biological Roles of Multivalent Ligands; 2 Multivalent Molecules Applied to Viral Targets; 2.1 Influenza Virus; 2.1.1 Hemagglutinin; 2.1.1.1 Divalent Sialic Acid 327 $a2.1.1.2 Tetravalent Sialoside2.1.1.3 Dendrimers Presenting Sialosides; 2.1.1.4 Sialic Acid Displayed in Liposomes; 2.1.1.5 Polymerized Liposome Presenting Sialic Acid; 2.1.1.6 Sialic Acid in Langmuir-Blodget Monolayers; 2.1.1.7 Sialic Acid Presented on Biopolymer Surfaces; 2.1.1.8 Poly(acrylamide) Presenting Sialosides; 2.1.1.9 Poly(acrylic acid) Presenting Sialosides; 2.1.1.10 Poly(acrylamide) Presenting C-Sialosides; 2.1.1.11 Postmodification of Activated Polymers; 2.1.1.12 Modes of Action of Polymeric Sialosides; 2.1.1.13 OPTCOL Assay; 2.1.1.14 ter-Poly(acrylic acid) Presenting Sialosides 327 $a2.1.1.15 Poly(glutamic acid) Presenting Lysogangliosides2.1.1.16 Poly(glutamic acid) Bearing Sialic Acid-Containing Trisaccharides; 2.1.1.17 Poly(acrylamide) Bearing Sialic Acid Linked at the C(4) Position; 2.1.1.18 Poly(acrylamide) Tethering 9-O-Acetylsialosides; 2.1.1.19 Neoglycoprotein Displaying Sialic Acids; 2.1.1.20 Natural b-Inhibitors; 2.1.2 Neuraminidase; 2.1.2.1 Poly(glutamic acid) Presenting NA Inhibitors; 2.2 Human Immunodeficiency Virus; 2.2.1 HIV-1 Protease; 2.2.1.1 Divalent Terminal Peptides; 2.2.2 HIV-1 Reverse Transcriptase; 2.2.2.1 Heterodimers Composed of NRTI and NNRTI 327 $a2.2.3 Glycoprotein 120 (gp120) on Viral Surfaces2.2.3.1 Neoglycoprotein-Displaying CD4 Peptide; 2.2.3.2 Galactosyl Ceramide Immobilized on Viral Surfaces; 2.2.3.3 Multivalent Anions; 2.2.3.4 Bivalent Antagonists of CXCR4; 2.2.4 Surface Carbohydrates on HIV; 2.2.4.1 Oligomannose Sugars Present on gp120; 2.2.4.2 Modes of CVN Recognition; 2.3 Rotavirus; 2.4 Polyoma Virus; 2.5 Picorna Virus; 2.6 Respiratory Syncytial Virus; 2.7 Dengue Virus; 2.8 Nucleic Acids of Viruses; 2.8.1 RNA-Protein Interactions; 2.8.1.1 Neomycin B Linked to Acridine; 2.8.1.2 Neamine Linked to Pyrene-Carboxylic Acid 327 $a2.8.2 RNA-Enzyme Interactions2.8.3 Binders to the Minor Groove of Viral DNA; 2.8.3.1 Hairpin-Shaped Polyamide Dimers; 2.8.3.2 H-Shaped Polyamide Dimers; 2.8.3.3 Naturally Occurring Dimers; 2.9 Synthetic Multivalent Vaccines; 2.9.1 Peptide-Based Anti-influenza Vaccines; 2.9.2 Gp41-Based Anti-HIV Vaccine; 2.9.3 Peptide-Based Anti-FMDV Vaccines; 3 Multivalent Molecules Applied to Bacterial Targets; 3.1 Targets in Bacterial Cell Membranes; 3.1.1 D-Ala-D-Ala Peptide Precursors; 3.1.1.1 Mode of Action by Antibiotics of the Vancomycin Class; 3.1.1.2 Dimerization of Glycopeptide Antibiotics 327 $a3.1.1.3 Di- and Trivalent Vancomycin 330 $aThis book provides basic principles of multivalent interactions found in biological systems as well as an up-to-date and thorough coverage in design concepts, syntheses, and biological activities of multivalent molecules.* Contains practical examples of synthetic multivalent molecules in chemistry, biology, and medicine* Can be used as both a textbook for students and a reference book for libraries and professionals* Includes detailed case studies* Fills a void in current literature through its devotion solely to multivalent molecules 606 $aMultivalent molecules$xSynthesis 606 $aMultivalent molecules$xDesign 606 $aMultivalent molecules$xPhysiological effect 608 $aElectronic books. 615 0$aMultivalent molecules$xSynthesis. 615 0$aMultivalent molecules$xDesign. 615 0$aMultivalent molecules$xPhysiological effect. 676 $a615.31 676 $a615/.31 700 $aChoi$b Seok-ki$f1964-$0950615 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910146077703321 996 $aSynthetic multivalent molecules$92149274 997 $aUNINA LEADER 02669nam 22004575 450 001 996453547603316 005 20220110023848.0 010 $a1-4875-4670-X 024 7 $a10.3138/9781487546700 035 $a(CKB)5590000000881907 035 $a(DE-B1597)617632 035 $a(DE-B1597)9781487546700 035 $a(EXLCZ)995590000000881907 100 $a20220110h20212022 fg 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDegrees of Dignity $eArab Higher Education in the Global Era /$fElizabeth Buckner 210 1$aToronto : $cUniversity of Toronto Press, $d[2021] 210 4$dİ2022 215 $a1 online resource (264 p.) $c8 b&w figures, 9 b&w tables 330 $aPresenting an analysis of higher education in eight countries in the Arab Middle East and North Africa, Degrees of Dignity works to dismantle narratives of crisis and assert approaches to institutional reform. Drawing on policy documents, media narratives, interviews, and personal experiences, Elizabeth Buckner explores how apolitical external reform models become contested and modified by local actors in ways that are simultaneously complicated, surprising, and even inspiring. Degrees of Dignity documents how the global discourses of neoliberalism have legitimized specific policy models for higher education reform in the Arab world, including quality assurance, privatization, and internationalization. Through a multi-level and comparative analysis, this book examines how policy models are implemented, with often complex results, in countries throughout the region. Ultimately, Degrees of Dignity calls on the field of higher education development to rethink current approaches to higher education reform: rather than viewing the Arab world as a site for intervention, it argues that the Arab world can act as a source for insight on resilient higher education systems. 606 $aEDUCATION / Higher$2bisacsh 610 $aArab higher education. 610 $aMiddle East. 610 $aNational university. 610 $aNorth Africa. 610 $ahigher education in North Africa. 610 $ahigher education in the Middle East. 610 $aprivate university. 615 7$aEDUCATION / Higher. 700 $aBuckner$b Elizabeth, $4aut$4http://id.loc.gov/vocabulary/relators/aut$01222528 712 02$aUniversity of Toronto Libraries$4fnd$4http://id.loc.gov/vocabulary/relators/fnd 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a996453547603316 996 $aDegrees of Dignity$92835452 997 $aUNISA