LEADER 05618nam 2200661 450 001 996426338303316 005 20200520144314.0 035 $a(CKB)2670000000612568 035 $a(EBL)2037828 035 $a(SSID)ssj0001534305 035 $a(PQKBManifestationID)12608986 035 $a(PQKBTitleCode)TC0001534305 035 $a(PQKBWorkID)11496053 035 $a(PQKB)10316915 035 $a(MiAaPQ)EBC2037828 035 $a(Au-PeEL)EBL2037828 035 $a(CaPaEBR)ebr11049158 035 $a(CaONFJC)MIL776949 035 $a(OCoLC)908670583 035 $a(EXLCZ)992670000000612568 100 $a20150509h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRegenerative engineering of musculoskeletal tissues and interfaces /$fedited by Syam P. Nukavarapu, Joseph W. Freeman and Cato T. Laurencin ; contributors, K. A. Athanasiou [and fifty seven others] 210 1$aAmsterdam, [Netherlands] :$cWoodhead Publishing,$d2015. 210 4$dİ2015 215 $a1 online resource (463 p.) 225 1 $aWoodhead Publishing Series in Biomaterials ;$vNumber 98 300 $aDescription based upon print version of record. 311 $a1-78242-314-1 311 $a1-78242-301-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Related titles; Regenerative Engineering of Musculoskeletal Tissues and Interfaces; Copyright; Dedication; Contents; List of contributors; Woodhead Publishing Series in Biomaterials; Part One - Basic elements of musculoskeletal tissue engineering; 1 - Biomaterials and scaffolds for musculoskeletal tissue engineering; 1.1 Introduction; 1.2 Biomaterials; 1.3 Physical property requirements; 1.4 Scaffolds for musculoskeletal tissue engineering; 1.5 Conclusion and future directions; Acknowledgments; References; 2 - Cells for musculoskeletal tissue engineering; 2.1 Introduction 327 $a2.2 Postnatal progenitor cells for musculoskeletal tissue engineering2.3 Prenatal progenitor cells for musculoskeletal tissue engineering; 2.4 Summary; Acknowledgments; References; 3 - Growth factors for musculoskeletal tissue engineering; 3.1 Introduction; 3.2 Origin and development of musculoskeletal tissues; 3.3 Molecular regulation of musculoskeletal system development; 3.4 Growth factor-based musculoskeletal tissue regeneration; 3.5 Current approaches for spatiotemporal control of growth factors; 3.6 Future directions; Acknowledgments; References 327 $a4 - Mechanical forces in musculoskeletal tissue engineering4.1 Introduction; 4.2 Mechanical forces in guiding differentiation and extracellular matrix production; 4.3 Mechanical stimuli for tissue regeneration; 4.4 Methods of introducing mechanical stimuli; References; Part Two - Individual musculoskeletaltissues; 5 - Bone tissue engineering; 5.1 Introduction; 5.2 Traditional concepts in bone tissue engineering; 5.3 Current and new strategies for engineered bone: discussion and examples; 5.4 Bone tissue engineering challenges and a vision for the future 327 $a5.5 The development challenges of an engineered bone productAcknowledgments; References; 6 - Cartilage tissue engineering; 6.1 Introduction; 6.2 Cartilage anatomy, physiology, and injury; 6.3 Current treatment options; 6.4 Tissue engineering considerations; 6.5 Conclusions; References; 7 - Ligament tissue engineering; 7.1 Introduction; 7.2 Ligament composition and structure; 7.3 Ligament mechanical properties; 7.4 Ligament injuries and their current clinical outcomes; 7.5 Options for surgical ligament replacement; 7.6 Summary; References; 8 - Tendon tissue engineering; 8.1 Introduction 327 $a8.2 Tendon structure and function8.3 Tendon injury and degeneration; 8.4 Tendon healing; 8.5 Current treatment: the traditional approach; 8.6 Tissue engineering approach; 8.7 Scaffolds; 8.8 Materials selection; 8.9 Nanofibers; 8.10 Mechanical stimulation; 8.11 Cells; 8.12 Growth factors; 8.13 Gene therapy; 8.14 Future trends; 8.15 Conclusions; Acknowledgments; References; 9 - Meniscus tissue engineering; 9.1 Structure, anatomy, and function of the meniscus; 9.2 Meniscus injury and repair; 9.3 Meniscus replacement; 9.4 Conclusions; References; 10 - Muscle tissue engineering; 10.1 Introduction 327 $a10.2 Skeletal muscle tissue 330 $a Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of c 410 0$aWoodhead Publishing series in biomaterials ;$vNumber 98. 606 $aTissue engineering 606 $aRegenerative medicine 608 $aElectronic books. 615 0$aTissue engineering. 615 0$aRegenerative medicine. 676 $a612.028 702 $aNukavarapu$b Syam P. 702 $aFreeman$b Joseph W. 702 $aLaurencin$b Cato T. 702 $aAthanasiou$b K. A. 801 0$bMiAaPQ 906 $aBOOK 912 $a996426338303316 996 $aRegenerative engineering of musculoskeletal tissues and interfaces$92184532 997 $aUNISA