LEADER 05167nam 2200601 450 001 996426329203316 005 20201010012434.0 010 $a0-444-63272-7 010 $a0-444-63269-7 035 $a(CKB)3710000000347689 035 $a(EBL)1938903 035 $a(SSID)ssj0001433982 035 $a(PQKBManifestationID)11754798 035 $a(PQKBTitleCode)TC0001433982 035 $a(PQKBWorkID)11417749 035 $a(PQKB)11429086 035 $a(MiAaPQ)EBC1938903 035 $a(PPN)200157396 035 $a(EXLCZ)993710000000347689 100 $a20150212h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aInfection and autoimmunity /$fedited by Yehuda Shoenfeld, Nancy Agmon-Levin, Noel R. Rose 205 $a2nd ed. 210 1$aLondon, England :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (1071 p.) 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Infection and Autoimmunity; Copyright ; Contents ; Contributors ; Chapter 1: Introduction; 1. Introduction; 2. Rheumatic Fever, A Prime Example; 3. Guillain-Barre? Syndrome, A Second Example; 4. Underlying Mechanisms; 5. Autoimmunity Vs. Autoimmune Disease: The Adjuvant Effect; 6. The Problems and the Promise; 7. Lessons of Molecular (Epitope) Mimicry; 8. Views of the Future; Acknowledgements; References; Chapter 2: Infections and Autoimmune Diseases: An Interplay of Pathogenic and Protective Links; 1. Introduction; 2. Pathogenic Roles of Infections; 2.1. Viruses; 2.2. Bacteria 327 $a2.3. Fungi2.4. Parasites; 3. Protective Role of Infections; References; Part 1: Mechanisms of Autoimmunity induction by infectious agents and vaccination; Chapter 3: Molecular Mimicry and Autoimmunity; 1. Introduction; 2. Common Infectious Agents and Their Roll in Setting Autoimmune Disorders; 2.1. Viruses; 2.2. Bacteria; 2.3. Parasites; 3. Neuro-Autoimmune Disease; 4. Endocrinological Autoimmune Disease; 5. Inflammatory Articular Disease; 6. Vasculitides; 6.1. Summary and Suggestions for the Future: `Control of Molecular mimicry; References 327 $aChapter 4: Epitope Spreading in Autoimmune Diseases1. Introduction; 2. Examples of Epitope Spreading in Autoimmune Diseases; 2.1. Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis; 2.2. Insulin-Dependent Diabetes Mellitus or Type I Diabetes; 2.3. Arthritis; 2.4. Systemic Lupus Erythematosus; 2.5. Other Autoimmune Diseases; 3. Mechanisms Underlying Epitope Spreading During the Course of an Autoimmune Disease; 3.1. Upregulation of the Display of Cryptic/Subdominant Epitopes Within a Self Antigen Under Inflammatory Conditions 327 $a3.2. Release of Self Antigens and Their Processing and Presentation Following Tissue Damage in the Course of a Microbial ...3.3. Post-Translational Modification of Antigens; 3.4. The Frequency and Avidity of Epitope-Specific Precursor T Cells Within the Mature T Cell Repertoire Favoring Respons...; 3.5. Presentation of Neo-Epitopes Within a Particular Self Antigen by the B Cells Specific for That Antigen; 3.6. The Influence of Antigen-Bound Antibodies on the Processing and Presentation of T Cell Epitopes Within That Antigen; 3.7. Antigen Cross-Presentation and Epitope Spreading 327 $a3.8. Site of Initiation of Epitope Spreading: Target Organ Versus the Periphery4. Physiological Significance of Epitope Spreading: Involvement of Epitope Spreading in the Pathogenesis of Autoimmune Di...; 5. Implications of Epitope Spreading in Immunotherapy of Autoimmune Diseases: Hindering vs. Facilitating the Control of t...; 6. Concluding Remarks; References; Chapter 5: CD5-Expressing B-1 Cells and Infection; 1. Introduction; 2. Characterization of CD5+ B Cells; 2.1. Origins of the Cells; 2.2. Functions of CD5+ B Cells; 2.3. Control of the CD5+ B Cell Population 327 $a3. CD5+ B Cells and Disease 330 $aAutoimmune diseases are conditions where the immune system attacks the body organs instead of foreign invaders. This book deals with the various mechanisms by which infectious agents can trigger autoimmunity such as molecular mimicry and polyclonal activation. An overview is given with regard to bacteria, viruses, and parasites associated with autoimmunity, and a summary is given on classical autoimmune diseases and the infecting agents that can induce them.Includes completely updated and new chaptersBrings the reader up to date and allows easy access to individual topics in one placeIdentifie 606 $aAutoimmune diseases$ximmunology. 606 $aInfections$ximmunology 608 $aElectronic books. 615 12$aAutoimmune diseases$ximmunology.. 615 12$aInfections$ximmunology. 676 $a616.97/8 702 $aShoenfeld$b Yehuda$f1948- 702 $aAgmon-Levin$b Nancy 702 $aRose$b Noel R. 801 0$bMiAaPQ 906 $aBOOK 912 $a996426329203316 996 $aInfection and autoimmunity$91922101 997 $aUNISA