LEADER 02998oam 2200469 450 001 996418445503316 005 20210415093533.0 010 $a3-030-60235-4 024 7 $a10.1007/978-3-030-60235-2 035 $a(CKB)4100000011508833 035 $a(DE-He213)978-3-030-60235-2 035 $a(MiAaPQ)EBC6381106 035 $a(PPN)252519132 035 $a(EXLCZ)994100000011508833 100 $a20210415d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOptical whispering gallery modes for biosensing $efrom physical principles to applications /$fFrank Vollmer, Deshui Yu 205 $a1st ed. 2020. 210 1$aCham, Switzerland :$cSpringer,$d[2020] 210 4$d©2020 215 $a1 online resource (XIII, 417 p. 142 illus.) 225 1 $aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 311 $a3-030-60234-6 327 $aFrom the Contents: Introduction: Need for label-free chip-scale clinical diagnostics and nanoparticle analyzers -- Fundamentals of photonics (light, wave, polarization, interference) -- Fundamental optical properties of biomolecules -- Light matter interaction with biomolecules (Lorentz- model, drude-model, light at a sensor interface, reflection, transmission, evanescent field) -- Physics of optical micro-resonators (fabry perot, microsphere, resonance, photonic atom model, photonic crystals, ring resonator, bottleneck resonator, microtube resonator, capillary resonator). 330 $aThis interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light?matter interaction, and biomolecular structure with a focus on applications in biosensing. Novel biosensors based on the hybridization of WGM microcavities and localized surface plasmon resonances (LSPRs) in metal nanoparticles have emerged as the most sensitive microsystem biodetection technology that boasts single molecule detection capability without the need for amplification and labeling of the analyte. The book provides an ample survey of the physical mechanisms of WGMs and LSPRs for detecting affinity, concentration, size, shape and orientation of biomarkers, while informing the reader about different classes of biomolecules, their optical properties and their importance in label-free clinical diagnostics. For the more advanced reader, advanced applications of WGMs and LSPRs in exploring the fundamental nature of quantum physics are discussed. . 410 0$aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 606 $aBiosensors 615 0$aBiosensors. 676 $a610.28 700 $aVollmer$b Frank$0843496 702 $aYu$b Deshui 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a996418445503316 996 $aOptical whispering gallery modes for biosensing$92255290 997 $aUNISA