LEADER 03390oam 2200505 450 001 996418441603316 005 20210506130302.0 010 $a3-030-60433-0 024 7 $a10.1007/978-3-030-60433-2 035 $a(CKB)4100000011586164 035 $a(DE-He213)978-3-030-60433-2 035 $a(MiAaPQ)EBC6404880 035 $a(PPN)25250819X 035 $a(EXLCZ)994100000011586164 100 $a20210506d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aX-ray phase-contrast tomography $eunderlying physics and developments for breast imaging /$fLuca Brombal 205 $a1st ed. 2020. 210 1$aCham, Switzerland :$cSpringer,$d[2020] 210 4$d©2020 215 $a1 online resource (XIII, 140 p. 68 illus., 53 illus. in color.) 225 1 $aSpringer Theses 311 $a3-030-60432-2 327 $aIntroduction -- Physics of Propagation-based X-ray Tomography -- Propagation-based Breast CT and SYRMA-3D Project -- Detector and Pre-processing -- Experimental Optimization of Propagation-based BCT -- Three-Dimensional Imaging: A Clinically Oriented Focus -- Do We Need Clinical Applications in Synchrotrons? -- Conclusions. 330 $aX-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals. . 410 0$aSpringer theses. 606 $aBreast$xCancer$xTomography 606 $aBreast$xCancer$xDiagnosis 606 $aBreast Neoplasms$xdiagnostic imaging 615 0$aBreast$xCancer$xTomography. 615 0$aBreast$xCancer$xDiagnosis. 615 0$aBreast Neoplasms$xdiagnostic imaging. 676 $a616.9944906 700 $aBrombal$b Luca$0928817 801 0$bCaPaEBR 801 1$bCaPaEBR 801 2$bUtOrBLW 906 $aBOOK 912 $a996418441603316 996 $aX-ray phase-contrast tomography$92087450 997 $aUNISA