LEADER 04531nam 2200481 450 001 996418316803316 005 20210301100743.0 010 $a3-030-60327-X 024 7 $a10.1007/978-3-030-60327-4 035 $a(CKB)5590000000002289 035 $a(MiAaPQ)EBC6362051 035 $a(DE-He213)978-3-030-60327-4 035 $a(PPN)254666833 035 $a(EXLCZ)995590000000002289 100 $a20210301d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aComputational methods in systems biology $e18th International Conference, CMSB 2020, Konstanz, Germany, September 23-25, 2020, Proceedings /$fAlessandro Abate, Tatjana Petrov, Verena Wolf, editors 205 $a1st ed. 2020. 210 1$aCham, Switzerland :$cSpringer,$d[2020] 210 4$dİ2020 215 $a1 online resource (XIX, 387 p. 208 illus., 57 illus. in color.) 225 1 $aLecture notes in computer science ;$v12314 311 $a3-030-60326-1 327 $aModelling and Analysis -- Rate Equations For Graphs -- Stationary Distributions and Metastable Behaviour for Self-Regulating Proteins with General Lifetime Distributions -- Accelerating Reactions at the DNA Can Slow Down Transient Gene Expression -- Graphical Conditions for Rate Independence in Chemical Reaction Networks -- Interval Constraint Satisfaction and Optimization for Biological Homeostasis and Multistationarity -- Growth Dependent Computation of Chokepoints in Metabolic Networks -- On the Complexity of Quadratization for Polynomial Differential Equations -- Comparing Probabilistic and Logic Programming Approaches to Predict the Effects of Enzymes in a Neurogenerative Disease Model -- Boolean Networks -- Control Strategy Identification via Trap Spaces in Boolean Networks -- Qualitative Analysis of Mammalian Circadian Oscillations: Cycle Dynamics and Robustness -- Synthesis and Simulation of Ensembles of Boolean Networks for Cell Fate Decision -- Classifier Construction in Boolean Networks Using Algebraic Methods -- Sequential Temporary and Permanent Control of Boolean Networks -- Inference and Identification -- ABC(SMC)^2: Simultaneous Inference and Model Checking of Chemical Reaction Networks -- Parameter Synthesis for Hybrid Systems from Hybrid CTL Specifications -- Core Models of Receptor Reactions Evaluate Basic Pathway Designs Enabling Heterogeneous Commitments to Apoptosis -- Drawing the Line: Basin Boundaries in Safe Petri Nets -- Tools -- ModRev - Model Revision Tool for Boolean Logical Models of Biological Regulatory Networks -- fnyzer: a Python Package for the Analysis of Flexible Nets -- eBCSgen: A Software Tool for Biochemical Space Language -- What is a Cell Cycle Checkpoint ? The TotemBioNet Answer -- Kaemika App, Integrating Protocols and Chemical Simulation -- Tutorials -- Tutorial: The CoLoMoTo Interactive Notebook, Accessible and Reproducible Computational Analyses for Qualitative Biological Networks -- Integrating Experimental Pharmacology and Systems Biology for GPCR Drug Discovery. 330 $aThis book constitutes the refereed proceedings of the 18th International Conference on Computational Methods in Systems Biology, CMSB 2020, held in Konstanz, Germany, in September 2020.* The 17 full papers and 5 tool papers were carefully reviewed and selected from 30 submissions. In addition 3 abstracts of invited talks and 2 tutorials have been included in this volume. Topics of interest include formalisms for modeling biological processes; models and their biological applications; frameworks for model verification, validation, analysis, and simulation of biological systems; high-performance computational systems biology and parallel implementations; model inference from experimental data; model integration from biological databases; multi-scale modeling and analysis methods; computational approaches for synthetic biology; and case studies in systems and synthetic biology. * The conference was held virtually due to the COVID-19 pandemic. 410 0$aLecture notes in computer science ;$v12314. 606 $aBioinformatics$vCongresses 615 0$aBioinformatics 676 $a572.80285 702 $aAbate$b Alessandro 702 $aPetrov$b Tatjana 702 $aWolf$b Verena 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996418316803316 996 $aComputational Methods in Systems Biology$92555043 997 $aUNISA