LEADER 01505nam 2200397Ia 450 001 996396649503316 005 20200824131940.0 035 $a(CKB)4940000000057348 035 $a(EEBO)2240924588 035 $a(OCoLC)ocm12390780e 035 $a(OCoLC)12390780 035 $a(EXLCZ)994940000000057348 100 $a19850815d1682 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA sermon against persecution$b[electronic resource] $epreached March 26. 1682, being the fourth Sunday in Lent, (on Gal. IV. 29. part of the epistle for that day) and the time when the brief for the persecuted Protestants in France was read in the parish church of Shapwicke, and now published to the consideration of violent and headstrong men, as well as to put a stop to false reports /$fby Sa. Bolde .. 205 $aThe second edition. 210 $aLondon $cPublished by R. Janeway$d1682 215 $a[4], 36 p 300 $aReproduction of original in Huntington Library. 330 $aeebo-0113 606 $aFreedom of religion$zGreat Britain$vSermons 606 $aSermons, English$y17th century 606 $aPersecution$vSermons 615 0$aFreedom of religion 615 0$aSermons, English 615 0$aPersecution 700 $aBold$b S$g(Samuel),$f1649-1737.$01001750 801 0$bEAA 801 1$bEAA 801 2$bm/c 801 2$bWaOLN 906 $aBOOK 912 $a996396649503316 996 $aA sermon against persecution$92299156 997 $aUNISA LEADER 01391nam 2200469 450 001 9910795240503321 005 20200520144314.0 010 $a1-351-60077-X 035 $a(CKB)4340000000208536 035 $a(MiAaPQ)EBC5103713 035 $a(Au-PeEL)EBL5103713 035 $a(CaPaEBR)ebr11454600 035 $a(OCoLC)1007049916 035 $a(EXLCZ)994340000000208536 100 $a20171115h20181976 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aSlum clearance $ethe social and administrative context in England and Wales /$fJohn English, Ruth Madigan, Peter Norman 210 1$aLondon, England ;$aNew York, New York :$cRoutledge,$d2018. 210 4$d1976 215 $a1 online resource (223 pages) 225 0 $aRoutledge Library Editions: Urban Studies ;$vVolume 9 300 $aIncludes index. 311 $a1-138-05750-9 606 $aUrban renewal$zEngland 606 $aUrban renewal$zWales 615 0$aUrban renewal 615 0$aUrban renewal 676 $a301.36/2/0942 700 $aEnglish$b John$f1944-$01482835 702 $aMadigan$b Ruth 702 $aNorman$b Peter C. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910795240503321 996 $aSlum clearance$93700723 997 $aUNINA LEADER 04108nam 22007214a 450 001 9911019323903321 005 20200520144314.0 010 $a9786610275267 010 $a9781280275265 010 $a128027526X 010 $a9780470021422 010 $a047002142X 010 $a9780470021415 010 $a0470021411 035 $a(CKB)1000000000357241 035 $a(EBL)232685 035 $a(SSID)ssj0000170472 035 $a(PQKBManifestationID)11171219 035 $a(PQKBTitleCode)TC0000170472 035 $a(PQKBWorkID)10223946 035 $a(PQKB)10515328 035 $a(MiAaPQ)EBC232685 035 $a(OCoLC)85820613 035 $a(Perlego)2784166 035 $a(EXLCZ)991000000000357241 100 $a20041130d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe hERG cardial potassium channel $estructure, function, and long QT syndrome /$f[editors, Derek J. Chadwick, James Goode] 210 $aNew York $cJ. Wiley$d2005 215 $a1 online resource (309 p.) 225 1 $aNovartis Foundation symposium ;$v266 300 $aBased on a symposium. 311 08$a9780470021408 311 08$a0470021403 320 $aIncludes bibliographical references and indexes. 327 $aTHE hERG CARDIAC POTASSIUM CHANNEL: STRUCTURE, FUNCTION AND LONG QT SYNDROME; Contents; Participants; Chair's introduction; Gating and assembly of heteromeric hERG1a/1b channels underlying I(Kr) in the heart; Discussion; Structure-function studies of the outer mouth and voltage sensor domain of hERG; Discussion; General discussion I; Voltage sensor movement in the hERGK(+) channel; Discussion; hERG channel trafficking; Discussion; Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3; Discussion; General discussion II 327 $aDoes hERG coassemble with a b subunit? Evidence for roles of MinK and MiRP1Discussion; hERG block, QT liability and sudden cardiac death; Discussion; Structural determinants for high-affinity block of hERG potassium channels; Discussion; Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs; Discussion; In silico modelling-pharmacophores and hERG channel models; Discussion; The long QTsyndrome: a clinical counterpart of HERG mutations; Discussion; Cellular mechanisms of Torsade de Pointes; Discussion 327 $aExpression and role of hERG channels in cancer cellsDiscussion; TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability); Discussion; Drug-induced QT interval prolongation: regulatory guidance and perspectives on hERG channel studies; Discussion; Closing remarks; Index of contributors; Subject index 330 $aThis book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channe 410 0$aNovartis Foundation symposium ;$v266. 606 $aPotassium channels$vCongresses 606 $aLong QT syndrome$vCongresses 606 $aHeart$xPhysiology$vCongresses 606 $aHeart$xPathophysiology$vCongresses 615 0$aPotassium channels 615 0$aLong QT syndrome 615 0$aHeart$xPhysiology 615 0$aHeart$xPathophysiology 676 $a612.1/7 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019323903321 996 $aThe hERG cardial potassium channel$94416159 997 $aUNINA