LEADER 01197nam 2200373Ia 450 001 996396584503316 005 20200824132619.0 035 $a(CKB)4940000000058232 035 $a(EEBO)2240960887 035 $a(OCoLC)ocm12758856e 035 $a(OCoLC)12758856 035 $a(EXLCZ)994940000000058232 100 $a19851105d1642 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aTwo sermons preached in the tovver$b[electronic resource] $ethe former, on Sunday the 30 day of Ianuary, 1641 : the later on Sunday the 24 day of April, 1642 /$fby the Bishop of Bath and Wells 210 $aLondon $cPrinted by T. H. for Charles Greene ...$d1642 215 $a[4], 80 p 300 $aErrata: p. 80. 300 $aReproduction of original in Thomason Collection, British Library. 330 $aeebo-0158 606 $aSermons, English 615 0$aSermons, English. 700 $aPiers$b William$f1580-1670.$01006916 701 $aW. D$0825272 801 0$bEAA 801 1$bEAA 801 2$bm/c 801 2$bUMI 801 2$bWaOLN 906 $aBOOK 912 $a996396584503316 996 $aTwo sermons preached in the tovver$92403925 997 $aUNISA LEADER 05337nam 2200685Ia 450 001 9911018822803321 005 20200520144314.0 010 $a9786610366477 010 $a9781280366475 010 $a1280366478 010 $a9780470352618 010 $a0470352612 010 $a9780471460732 010 $a0471460737 010 $a9780471220398 010 $a0471220396 035 $a(CKB)1000000000019004 035 $a(EBL)159849 035 $a(OCoLC)181842495 035 $a(SSID)ssj0000309901 035 $a(PQKBManifestationID)11237643 035 $a(PQKBTitleCode)TC0000309901 035 $a(PQKBWorkID)10283312 035 $a(PQKB)10789104 035 $a(MiAaPQ)EBC159849 035 $a(Perlego)2775373 035 $a(EXLCZ)991000000000019004 100 $a19991220d2000 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSolid phase synthesis and combinatorial technologies /$fPierfausto Seneci 210 $aNew York $cJohn Wiley & Sons$dc2000 215 $a1 online resource (653 p.) 300 $aDescription based upon print version of record. 311 08$a9780471331957 311 08$a0471331953 320 $aIncludes bibliographical references and index. 327 $aSOLID-PHASE SYNTHESIS AND COMBINATORIAL TECHNOLOGIES; CONTENTS; Preface; 1 Solid-Phase Synthesis: Basic Principles; 1.1 Solid Supports; 1.2 Linkers; 1.3 Reaction Monitoring in Solid-Phase Synthesis; 1.4 Purity and Yield Determination in Solid-Phase Synthesis; References; 2 Solid-Phase Synthesis: Oligomeric Molecules; 2.1 Peptides; 2.2 Oligonucleotides; 2.3 Oligosaccharides; References; 3 Solid-Phase Synthesis: Small Organic Molecules; 3.1 Small Organic Molecules on Solid Phase: Target Selection and Solution Studies; 3.2 Small Organic Molecules on Solid Phase: Solid-Phase Synthesis 327 $a3.3 Small Organic Molecules on Solid Phase: From Solid-Phase Synthesis to Synthetic Organic Libraries3.4 An Example: Solid-Phase Synthesis of 1H-[2]Pyrindinones; 3.5 Solid-Phase Synthetic Strategies: Selected Examples; References; 4 Combinatorial Technologies: Basic Principles; 4.1 Combinatorial Technologies; 4.2 Combinatorial Libraries; References; 5 Synthetic Organic Libraries: Library Design and Properties; 5.1 Primary Libraries: Shooting in the Dark?; 5.2 Focused Libraries: High-Throughput Structure--Activity Relationships; 5.3 Biased-Targeted Libraries: Information-Rich Primary Libraries 327 $a5.4 Library Design via Computational ToolsReferences; 6 Synthetic Organic Libraries: Solid-Phase Discrete Libraries; 6.1 Synthesis of Solid-Phase Discrete Libraries; 6.2 Structure Determination, Quality Control, and Purification of Solid-Phase Discrete Libraries; 6.3 Examples of Solid-Phase Discrete Library Synthesis; 6.4 New Trends in Solid-Phase Discrete Library Synthesis; References; 7 Synthetic Organic Libraries: Solid-Phase Pool Libraries; 7.1 Synthesis of Solid-Phase Pool Libraries; 7.2 Direct Structure Determination of Positives from Solid-Phase Pool Libraries 327 $a7.3 Deconvolution Methods for Solid-Phase Pool Libraries7.4 Encoding Methods for Solid-Phase Pool Libraries; 7.5 New Trends in Solid-Phase Pool Libraries; References; 8 Synthetic Organic Libraries: Solution-Phase Libraries; 8.1 Solution- Versus Solid-Phase Synthetic Libraries: Which Ones to Use?; 8.2 Solution-Phase Discrete Libraries; 8.3 Purification of Solution-Phase Library Intermediates and Final Compounds: Liquid-Liquid and Solid-Phase Extraction Systems; 8.4 Solid-Phase Assisted Solution-Phase Library Synthesis and Purification 327 $a8.5 Soluble Supports in Solution-Phase Combinatorial Synthesis8.6 New Trends in Solution-Phase Combinatorial Synthesis; References; 9 Applications of Synthetic Libraries; 9.1 Pharmaceutical Applications; 9.2 Agrochemical and Food-Related Applications; 9.3 Applications to Combinatorial Reaction Optimization; 9.4 Applications to Catalysis; 9.5 Applications to Molecular Recognition; References; 10 Biosynthetic Combinatorial Libraries; 10.1 Biosynthetic Polypeptide Libraries; 10.2 Biosynthetic Oligonucleotide Libraries; 10.3 Combinatorial Biosynthesis of Natural Products 327 $a10.4 Combinatorial Biocatalysis 330 $aA unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatoria 606 $aSolid-phase synthesis 606 $aCombinatorial chemistry 615 0$aSolid-phase synthesis. 615 0$aCombinatorial chemistry. 676 $a547/.2 700 $aSeneci$b Pierfausto$f1960-$0542916 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911018822803321 996 $aSolid phase synthesis and combinatorial technologies$92069227 997 $aUNINA