LEADER 04795nam 2200613Ia 450 001 9910456170603321 005 20200520144314.0 010 $a1-280-18464-7 010 $a9786610184644 010 $a0-309-57011-5 035 $a(CKB)111069351123168 035 $a(EBL)3377445 035 $a(SSID)ssj0000250579 035 $a(PQKBManifestationID)11204740 035 $a(PQKBTitleCode)TC0000250579 035 $a(PQKBWorkID)10244692 035 $a(PQKB)10867679 035 $a(MiAaPQ)EBC3377445 035 $a(Au-PeEL)EBL3377445 035 $a(CaPaEBR)ebr10071474 035 $a(CaONFJC)MIL18464 035 $a(OCoLC)923270666 035 $a(EXLCZ)99111069351123168 100 $a20010815d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStanding operating procedures for developing acute exposure guideline levels for hazardous chemicals$b[electronic resource] /$fSubcommittee on Acute Exposure Guideline Levels ...[et al.] 210 $aWashington ;$a[England] $cNational Academy Press$dc2001 215 $a1 online resource (224 p.) 300 $aDescription based upon print version of record. 311 $a0-309-07553-X 320 $aIncludes bibliographical references. 327 $a""Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals""; ""Copyright""; ""Preface""; ""Contents""; ""Introduction""; ""REVIEW OF THE NAC DOCUMENT""; ""REFERENCES""; ""Roster National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances""; ""COMMITTEE MEMBERS""; ""Past Committee Members""; ""Participants from Cooperative Partner Countries""; ""Other Participants""; ""Oak Ridge National Laboratory Staff""; ""AEGL Program Senior Staff""; ""Appendix""; ""Preface"" 327 $a""1. Overview of AEGL Program and NAC/AEGL Committee""""HISTORY""; ""PURPOSE AND OBJECTIVES OF THE AEGL PROGRAM AND THE NAC/AEGL COMMITTEE""; ""COMMITTEE MEMBERSHIP AND ORGANIZATIONAL STRUCTURE""; ""SELECTION OF CHEMICALS FOR AEGL DEVELOPMENT""; ""SCIENTIFIC CREDIBILITY OF AEGL VALUES""; ""THE AEGL DEVELOPMENT AND PEER-REVIEW PROCESS""; ""Stage 1: Draft AEGLs""; ""Stage 2: Proposed AEGLs""; ""Stage 3: Interim AEGLs""; ""Stage 4: Final AEGLs""; ""OPERATION OF THE NAC/AEGL COMMITTEE""; ""VALUE OF A COLLABORATIVE EFFORT IN THE AEGL PROGRAM""; ""APPLICATIONS OF THE AEGL VALUES"" 327 $a""2. Derivation of AEGL Values""""2.1 CHARACTERIZATION OF AEGLS""; ""2.2 EMPIRICAL TOXICOLOGIC ENDPOINTS AND METHODS FOR DETERMINING EXPOSURE CONCENTRATIONS USED TO DERIVE AEGLS 1, 2, AND 3""; ""2.2.1 Selection of the Highest Exposure Level at Which the Effects That Define an AEGL Are Not Observed""; ""2.2.2 Selection of Health-Effect Endpoints for AEGL-1, AEGL-2, and AEGL-3""; ""2.2.2.1 AEGL-1 Endpoints""; ""2.2.2.1.1 No Value Establisheda???AEGL-1 Is Close to or Exceeds AEGL-2""; ""2.2.2.1.2 No Value Establisheda???Insufficient Data"" 327 $a""2.2.2.1.3 Highest Experimental Exposure Without an AEGL-1 Effect""""2.2.2.1.4 Effect Level for a Response""; ""2.2.2.2 AEGL-2 Endpoints""; ""2.2.2.2.1 Highest Experimental Exposure Without an AEGL-2 Effect""; ""2.2.2.2.2 Effect Level for a Toxic Response That Was Not Incapacitating or Not Irreversible""; ""2.2.2.2.3 A Fraction of the AEGL-3 Value""; ""2.2.2.3 AEGL-3 Endpoints""; ""2.2.2.3.1 Highest Exposure Level That Does Not Cause Lethalitya???Experimentally Observed Threshold (AEGL-3 NOAEL)"" 327 $a""2.2.2.3.2 Highest Exposure Level That Does Not Cause Lethalitya???Estimated Lethality Thresholda???One-Third of the LC50""""2.2.2.3.3 Highest Exposure Level That Does Not Cause Lethalitya???Benchmark Exposure Calculation of the 5% and 1% Response""; ""2.2.2.3.4 Effect Level for a Response""; ""2.3 GUIDELINES AND CRITERIA FOR THE SEARCH STRATEGY, EVALUATION, SELECTION, AND DOCUMENTATION OF KEY DATA AND SUPPORTINGa???""; ""2.3.1 Search Strategy""; ""2.3.2 Evaluation, Selection, and Documentation of Key and Supporting Data""; ""2.3.3 Elements for Discussion on Data Adequacy and Research Needs"" 327 $a""2.4 DOSIMETRY CORRECTIONS FROM ANIMAL TO HUMAN EXPOSURES"" 606 $aHazardous substances$xRisk assessment$zUnited States 606 $aChemicals$xPhysiological effect 608 $aElectronic books. 615 0$aHazardous substances$xRisk assessment 615 0$aChemicals$xPhysiological effect. 676 $a363.1763 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910456170603321 996 $aStanding operating procedures for developing acute exposure guideline levels for hazardous chemicals$91959365 997 $aUNINA LEADER 01683nam 2200361Ia 450 001 996393628003316 005 20210104171954.0 035 $a(CKB)4940000000119730 035 $a(EEBO)2240875499 035 $a(OCoLC)ocm69648649e 035 $a(OCoLC)69648649 035 $a(EXLCZ)994940000000119730 100 $a20060530d1647 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 13$aAn ordinance of the Lords and Commons assembled in Parliament$b[electronic resource] $efor the repairing of churches, and paying of all church-duties whatsoever within the kingdome of England, and dominion of Wales 210 $aImprinted at Kondon [sic] $cfor John Wright at the Kings Head in the Old Bayley$d1647 215 $a[2], 10 p 300 $a"Die Mercurii, 9 Februarii. 1647. Ordered by the Lords assembled in Parliament, that this ordinance for repairing churches, and paying church-duties, be forthwith printed and published, and sent to all churches and chappels within the kingdome of England and dominion of Wales." 300 $aTitle within ornamental border. 300 $aReproduction of original in: Peterborough Cathedral. 330 $aeebo-0124 606 $aChurch maintenance and repair$zEngland$vEarly works to 1800 606 $aChurch maintenance and repair$zWales$vEarly works to 1800 607 $aEngland$xChurch history$y17th century$vEarly works to 1800 615 0$aChurch maintenance and repair 615 0$aChurch maintenance and repair 801 0$bUMI 801 1$bUMI 906 $aBOOK 912 $a996393628003316 996 $aAn ordinance of the Lords and Commons assembled in Parliament$92298865 997 $aUNISA LEADER 05399nam 2200649Ia 450 001 9910830815803321 005 20230607223700.0 010 $a1-283-29482-6 010 $a9786613294821 010 $a1-118-20422-0 010 $a1-118-15049-X 035 $a(CKB)2550000000055737 035 $a(EBL)818799 035 $a(OCoLC)757511766 035 $a(SSID)ssj0000550641 035 $a(PQKBManifestationID)11379938 035 $a(PQKBTitleCode)TC0000550641 035 $a(PQKBWorkID)10509204 035 $a(PQKB)11470726 035 $a(MiAaPQ)EBC818799 035 $a(EXLCZ)992550000000055737 100 $a20010710d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aExperiments with mixtures$b[electronic resource] $edesigns, models, and the analysis of mixture data /$fJohn A. Cornell 205 $a3rd ed. 210 $aNew York $cWiley$dc2002 215 $a1 online resource (682 p.) 225 1 $aWiley series in probability and statistics 300 $a"A Wiley-Interscience publication." 311 $a0-471-39367-3 320 $aIncludes bibliographical references and index. 327 $aExperiments with Mixtures: Designs, Models, and the Analysis of Mixture Data; Contents; Preface to the Third Edition; Preface to the Second Edition; 1. Introduction; 1.1. The Original Mixture Problem; 1.2. General Remarks About Response Surface Methods; 1.3. A Factorial Experiment or a Mixture Experiment?; 1.4. An Historical Perspective; References and Recommended Reading; Questions; 2. The Original Mixture Problem: Designs and Models for Exploring the Entire Simplex Factor Space; 2.1. The Simplex-Lattice Designs; 2.2. The Canonical Polynomials 327 $a2.3. The Polynomial Coefficients as Functions of the Responses at the Points of the Lattices2.4. Estimating the Parameters in the {q,m} Polynomials; 2.5. Properties of the Estimate of the Response y(x); 2.6. A Three-Component Yarn Example Using a {3,2} Simplex-Lattice Design; 2.7. The Analysis of Variance Table; 2.8. Analysis of Variance Calculations of the Yarn Elongation Data; 2.9. The Plotting of Individual Residuals; 2.10. Testing the Degree of the Fitted Model: A Quadratic Model or Planar Model?; 2.11. Some Comments on the Use of Check Points for Testing Model Lack of Fit 327 $a2.12. A Numerical Example Illustrating the Use of Check Points for Testing Lack of Fit2.13. The Simplex-Centroid Design and the Associated Polynomial Model; 2.14. An Application of a Four-Component Simplex-Centroid Design. Blending Chemical Pesticides for Control of Mites; 2.15. Axial Designs; 2.16. Comments on a Comparison Made Between an Augmented Simplex-Centroid Design and a Full Cubic Lattice for Three Components Where Each Design Contains Ten Points; 2.17. Reparameterizing Scheffe?'s Mixture Models to Contain a Constant (ß0) Term: A Numerical Example 327 $a2.18. Questions to Consider at the Planning Stages of a Mixture Experiment2.19. Summary; References and Recommended Reading; Questions; Appendix 2A. Least-Squares Estimation Formulas for the Polynomial Coefficients and Their Variances: Matrix Notation; Appendix 2B. Cubic and Quartic Polynomials and Formulas for the Estimates of the Coefficients; Appendix 2C. The Partitioning of the Sources in the Analysis of Variance Table When Fitting the Scheffe? Mixture Models; 3. The Use of Independent Variables; 3.1. Transforming from the q Mixture Components to q-1 Mathematically Independent Variables 327 $a3.2. A Numerical Example: Sensory Flavor Rating of Fish Patties3.3. Defining a Region of Interest Inside the Simplex: An Ellipsoidal Region; 3.4. A Numerical Illustration of the Inverse Transformation from the Design Variables to the Mixture Components; 3.5. Enlarging the Unit Spherical Region of Interest; 3.6. Some Discussion on Design Strategy When Fitting Response Surfaces; 3.7. Rotatable Designs; 3.8. A Second-Order Rotatable Design for a Four-Component System; 3.9. Defining a Cuboidal Region of Interest in the Mixture System; 3.10. Summary; References and Recommended Reading; Questions 327 $aAppendix 3A. An Alternative Transformation from the Mixture Component System to the Independent Variable System 330 $aThe most comprehensive, single-volume guide to conducting experiments with mixtures""If one is involved, or heavily interested, in experiments on mixtures of ingredients, one must obtain this book. It is, as was the first edition, the definitive work.""-Short Book Reviews (Publication of the International Statistical Institute)""The text contains many examples with worked solutions and with its extensive coverage of the subject matter will prove invaluable to those in the industrial and educational sectors whose work involves the design and analysis of mixture experiments." 410 0$aWiley series in probability and statistics. 606 $aExperimental design 606 $aMixtures$xStatistical methods 615 0$aExperimental design. 615 0$aMixtures$xStatistical methods. 676 $a519.5 676 $a519.5/38 700 $aCornell$b John A.$f1941-$0105138 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830815803321 996 $aExperiments with mixtures$9196572 997 $aUNINA