LEADER 01829nam 2200409 n 450 001 996390541903316 005 20200824120748.0 035 $a(CKB)4940000000102245 035 $a(EEBO)2240858368 035 $a(UnM)99841611e 035 $a(UnM)99841611 035 $a(EXLCZ)994940000000102245 100 $a19910410d1573 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 14$aThe garden of pleasure$b[electronic resource] $econtayninge most pleasante tales, worthy deeds and witty sayings of noble princes [et] learned philosophers, moralized. No lesse delectable, than profitable. Done out of Italian into English, by Iames Sanforde, Gent. Wherein are also set forth diuers verses and sentences in Italian, with the Englishe to the same, for the benefit of students in both tongs 210 $aImprinted at London $cBy Henry Bynneman$dAnno. 1573 215 $a[4], 111, [1] leaves 300 $aA translation of: Guicciardini, Lodovico. L'hore di ricreatione. 300 $aColophon reads: Imprinted at London by Henry Bynneman, dvvelling in Knight riders streate, at the signe of the Mermayde. Anno. 1573. And are to be sold at his shop at the northwest dore of Poules Church. 300 $aRunning title reads: Graue sayings & pleasant deedes. 300 $aReproduction of the original in the Henry E. Huntington Library and Art Gallery. 330 $aeebo-0113 606 $aAnecdotes$zItaly 606 $aProverbs, Italian 615 0$aAnecdotes 615 0$aProverbs, Italian. 700 $aGuicciardini$b Lodovico$f1521-1589.$0450077 701 $aSandford$b James$01009705 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996390541903316 996 $aThe garden of pleasure$92387352 997 $aUNISA LEADER 01095nam a2200289 i 4500 001 991003170009707536 008 040715s2003 it b 001 0 ita d 020 $a8815095128 035 $ab13034455-39ule_inst 040 $aDip.to Studi Giuridici$bita 082 $a938.04092 100 1 $aBanfi, Antonio$0122731 245 13$aIl governo della cittą :$bPericle nel pensiero antico /$cAntonio Banfi 260 $a[Bologna] :$bIl Mulino,$c2003 300 $axvii, 294 p. ;$c24 cm 440 0$aIstituto italiano per gli studi storici 504 $aInclude riferimenti bibliografici (p. [257]-274) e indici 600 00$aPericles,$d499-429 B.C. 650 4$aStoriografia$zGrecia$xStoria 650 4$aFilosofia antica 651 0$aAtene (Grecia)$xPolitica e Governo$xStoriografia 907 $a.b13034455$b02-04-14$c15-07-04 912 $a991003170009707536 945 $aLE027 R-XI 54$g1$i2027000062157$lle027$o-$pE30.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i13651705$z15-07-04 996 $aGoverno della cittą$9287826 997 $aUNISALENTO 998 $ale027$b15-07-04$cm$da $e-$fita$git $h3$i0 LEADER 05508nam 22007331 450 001 9910822951103321 005 20240401171533.0 010 $a9783527659708 010 $a3527659706 010 $a9783527659685 010 $a3527659684 010 $a9783527659715 010 $a3527659714 035 $a(CKB)2670000000414477 035 $a(EBL)1380171 035 $a(SSID)ssj0001152667 035 $a(PQKBManifestationID)11682034 035 $a(PQKBTitleCode)TC0001152667 035 $a(PQKBWorkID)11148963 035 $a(PQKB)10165034 035 $a(Au-PeEL)EBL1380171 035 $a(CaPaEBR)ebr10763015 035 $a(CaONFJC)MIL516716 035 $a(PPN)175440433 035 $a(OCoLC)858657953 035 $a(MiAaPQ)EBC1380171 035 $a(Perlego)999829 035 $a(EXLCZ)992670000000414477 100 $a20130704d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAntibiotics $etargets, mechanisms and resistance /$fedited by Claudio O. Gualerzi [and three others] 205 $a1st ed. 210 1$aWeinheim :$cWiley-VCH,$d2013. 215 $a1 online resource (575 p.) 300 $aDescription based upon print version of record. 311 08$a9783527333059 311 08$a3527333053 311 08$a9781299854659 311 08$a1299854656 320 $aIncludes bibliographical references and index. 327 $aTitle Page; Copyright; Contents; Preface; List of Contributors; Chapter 1 A Chemist's Survey of Different Antibiotic Classes; 1.1 Introduction; 1.2 Aminoglycosides; 1.3 ?-Lactams; 1.4 Linear Peptides; 1.4.1 Glycopeptides-Dalbaheptides; 1.4.2 Lantibiotics; 1.5 Cyclic Peptides; 1.6 Thiazolylpeptides; 1.7 Macrolactones; 1.7.1 Macrolides; 1.7.2 Difimicin; 1.8 Ansamycins-Rifamycins; 1.9 Tetracyclines; 1.10 Oxazolidinones; 1.11 Lincosamides; 1.12 Pleuromutilins; 1.13 Quinolones; 1.14 Aminocoumarins; References; Chapter 2 Antibacterial Discovery: Problems and Possibilities; 2.1 Introduction 327 $a2.2 Why Is Antibacterial Discovery Difficult? The Problems2.3 Target Choice: Essentiality; 2.4 Target Choice: Resistance; 2.5 Cell Entry; 2.6 Screening Strategies; 2.6.1 Empirical Screens; 2.6.2 Phenotypic Whole-Cell Screens; 2.6.3 In Vitro Screens for Single-Target Inhibitors; 2.6.4 Chemicals to Screen; 2.6.4.1 Chemical Collections; 2.7 Natural Products; 2.8 Computational Chemistry, Virtual Screening, Structure- and Fragment-Based Drug Design (SBDD and FBDD); 2.9 Conclusions; References; Chapter 3 Impact of Microbial Natural Products on Antibacterial Drug Discovery; 3.1 Introduction 327 $a3.2 Natural Products for Drug Discovery3.3 Microbial Natural Products; 3.4 The Challenge of Finding Novel Antibiotics from New Natural Sources; 3.5 Workflow for Drug Discovery from Microbial Natural Products; 3.6 Antimicrobial Activities: Targets for Screens; 3.7 Natural Products: A Continuing Source for Inspiration; 3.8 Genome Mining in Natural Product Discovery; 3.9 Conclusions; References; Chapter 4 Antibiotics and Resistance: A Fatal Attraction; 4.1 To Be or Not to Be Resistant: Why and How Antibiotic Resistance Mechanisms Develop and Spread among Bacteria 327 $a4.1.1 Horizontal and Vertical Transmission of Resistance Genes4.2 Bacterial Resistance to Antibiotics by Enzymatic Degradation or Modification; 4.2.1 Antibiotic Resistance by Hydrolytic Enzymes; 4.2.1.1 I?2-Lactamases; 4.2.1.2 Macrolide Esterases; 4.2.1.3 Epoxidases; 4.2.1.4 Proteases; 4.2.2 Antibiotic Transferases Prevent Target Recognition; 4.2.2.1 Acyltransfer; 4.2.2.2 Phosphotransferases; 4.2.2.3 Nucleotidyltransferases; 4.2.2.4 ADP-Ribosyltransferases; 4.2.2.5 Glycosyltransferases; 4.2.3 Redox Enzymes; 4.3 Antibiotic Target Alteration: The Trick Exists and It Is in the Genetics 327 $a4.3.1 Low-Affinity Homologous Genes4.3.1.1 Rifamycin Low-Affinity RpoB; 4.3.1.2 Mutated Genes Conferring Resistance to Quinolone, Fluoroquinolone and Aminocoumarins; 4.3.1.3 PBP2a: A Low-Affinity Penicillin-Binding Protein; 4.3.1.4 Dihydropteroate Synthases Not Inhibited by Sulfonamide; 4.3.2 Chemical Modification of Antibiotic Target; 4.3.2.1 23S rRNA Modification; 4.3.2.2 16S rRNA Modification; 4.3.2.3 Reprogramming Chemical Composition of a Bacterial Cell-Wall Precursor; 4.3.3 Ribosomal Protection and Tetracycline Resistance 327 $a4.3.4 Chromosomal Mutations in Genes Required for Membrane Phospholipid Metabolism: Lipopeptide Resistance 330 $aMost of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, ribo 606 $aAntibiotics 606 $aAnti-infective agents 615 0$aAntibiotics. 615 0$aAnti-infective agents. 676 $a615.329 701 $aGualerzi$b Claudio O.$f1942-$01705294 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910822951103321 996 $aAntibiotics$94091891 997 $aUNINA