LEADER 01389nam 2200385 n 450 001 996390210903316 005 20221108074511.0 035 $a(CKB)1000000000651627 035 $a(EEBO)2248565748 035 $a(UnM)99840560 035 $a(EXLCZ)991000000000651627 100 $a19910222d1602 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 14$aThe art of stenographie$b[electronic resource] $eteaching by plaine and certaine rules, to the capacitie of the meanest, and for the vse of all professions, the way of compendious writing. Wherevnto is annexed a very easie direction for stegan'ographie, or, secret writing 210 $aAt London $cPrinted [by W. White] for Cuthbert Burbie$d1602 215 $a[100] p. $ctable 300 $aBy John Willis. 300 $aPrinter's name from STC. 300 $aIncludes folded table, bound after G2, final leaf. 300 $aSignatures: A-F G² . 300 $asome pages marked. 300 $aReproduction of the original in the Folger Shakespeare Library. 330 $aeebo-0055 606 $aShorthand$vEarly works to 1800 615 0$aShorthand 700 $aWillis$b John$fd. 1625.$01001922 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996390210903316 996 $aThe art of stenographie$92302503 997 $aUNISA LEADER 02560nam 2200349 450 001 9910688469503321 005 20230623210918.0 010 $a3-03842-990-2 035 $a(CKB)5400000000000144 035 $a(NjHacI)995400000000000144 035 $a(EXLCZ)995400000000000144 100 $a20230623d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCyclic Nucleotide Signaling and the Cardiovascular System /$fedited by Thomas Brand, Enno Klussmann 210 1$aBasel :$cMDPI,$d2018. 215 $a1 online resource (306 pages) 330 $aThe cyclic nucleotides 3',5'-adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) play important roles in the control of cardiovascular function under physiological and pathological conditions. In this book, which is a reprint of a Special Issue of the Journal of Cardiovascular Development and Disease entitled "Cyclic Nucleotide Signaling and the Cardiovascular System", internationally recognized experts give an overview of this vibrant scientific field. The first series of articles deal with the localization and function of membrane-bound and soluble adenylate cyclases, followed by articles on the roles of phosphodiesterase isoforms in the heart. Cyclic nucleotide signaling takes place in nanodomains and the A-kinase anchor proteins (AKAPS) are essential for the compartmentalized assembly of signaling proteins into functional complexes. Reviews on the role of AKAP proteins in the physiology and pathophysiology of the heart are also included in this book. Cyclic nucleotides act through effector proteins and articles on EPAC and POPDC proteins inform the reader of recent developments on these topics. A major advancement in our understanding of cyclic nucleotide signaling came through the use of genetically encoded cAMP sensor molecules, and a series of articles review the current insight that these reporter molecules have provided. The final set of articles in this book deals with the association of the cyclic nucleotide pathway and cardiovascular disease as well as the development of novel therapeutic approaches. 606 $aNucleotides 615 0$aNucleotides. 676 $a547.79 702 $aKlussmann$b Enno 702 $aBrand$b Thomas 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910688469503321 996 $aCyclic Nucleotide Signaling and the Cardiovascular System$92943092 997 $aUNINA