LEADER 01726nam 2200385 n 450 001 996390144203316 005 20200818223941.0 035 $a(CKB)4940000000099393 035 $a(EEBO)2248495260 035 $a(UnM)99828677e 035 $a(UnM)99828677 035 $a(EXLCZ)994940000000099393 100 $a19950426d1699 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aParsons his Christian directory$b[electronic resource] $ebeing a treatise of holy resolution. In two parts. Put into modern English; and now made publick, for the instruction of the ignorant; the conviction of the unbelieving; the awakning and reclaiming the vicious, and for, confirming the religious in their good purposes 210 $aLondon $cprinted for Richard Sare at Grays-Inn-Gate in Holborn$dMDCXCIX. [1699] 215 $a[8], 80, 63-366, 351-490, [4] p 300 $aSignatures: A-E G-2L. 300 $aTable of contents: [4] p. at end. 300 $aApparent break in text between E8 and G1 in spite of catchword on E8; text appears to be continuous from G1 to end. 300 $aAn abridgement of an anonymous Protestant adaptation of Robert Parsons' "A Christian directorie", first published as "The first booke of the Christian exercise.". 330 $aeebo-0018 606 $aChristian life$xProtestant authors$vEarly works to 1800 615 0$aChristian life$xProtestant authors 701 $aParsons$b Robert$f1546-1610.$0138049 701 $aParsons$b Robert$f1546-1610.$0138049 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996390144203316 996 $aParsons his Christian directory$92299540 997 $aUNISA LEADER 03459nam 2200397z- 450 001 9910220044003321 005 20210211 035 $a(CKB)3800000000216337 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53834 035 $a(oapen)doab53834 035 $a(EXLCZ)993800000000216337 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Dynamics at the Immunological Synapse 210 $cFrontiers Media SA$d2017 215 $a1 online resource (120 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-133-X 330 $aThe immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies. 606 $aMedicine and Nursing$2bicssc 610 $acytoskeleton dynamics 610 $aendosomal dynamics 610 $aImmunological Synapse 610 $aintracellular signalling 615 7$aMedicine and Nursing 700 $aPedro Roda-Navarro$4auth$01315278 702 $aAndres Alcover$4auth 702 $aVincenzo Di Bartolo$4auth 906 $aBOOK 912 $a9910220044003321 996 $aMolecular Dynamics at the Immunological Synapse$93032332 997 $aUNINA