LEADER 05318nam 2200661Ia 450 001 9910458809103321 005 20200520144314.0 010 $a1-282-70770-1 010 $a9786612707704 010 $a0-470-62653-4 035 $a(CKB)2670000000032881 035 $a(EBL)554997 035 $a(OCoLC)651601898 035 $a(SSID)ssj0000418303 035 $a(PQKBManifestationID)11261264 035 $a(PQKBTitleCode)TC0000418303 035 $a(PQKBWorkID)10371080 035 $a(PQKB)11123831 035 $a(MiAaPQ)EBC554997 035 $a(PPN)159210178 035 $a(Au-PeEL)EBL554997 035 $a(CaPaEBR)ebr10411573 035 $a(CaONFJC)MIL270770 035 $a(EXLCZ)992670000000032881 100 $a20091224d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFundamentals of heterocyclic chemistry$b[electronic resource] $eimportance in nature and in the synthesis of pharmaceuticals /$fLouis D. Quin, John A. Tyrell 210 $aHoboken, N.J. $cWiley$dc2010 215 $a1 online resource (345 p.) 300 $aDescription based upon print version of record. 311 $a0-470-56669-8 320 $aIncludes bibliographical references and index. 327 $aFUNDAMENTALS OF HETEROCYCLIC CHEMISTRY; CONTENTS; PREFACE; ACKNOWLEDGMENT; Chapter 1 THE SCOPE OF THE FIELD OF HETEROCYCLIC CHEMISTRY; References; Appendix; Chapter 2 COMMON RING SYSTEMS AND THE NAMING OF HETEROCYCLIC COMPOUNDS; 2.1. General; 2.2. Naming Simple Monocyclic Compounds; 2.3. Handling the "Extra Hydrogen"; 2.4. Substituted Monocyclic Compounds; 2.5. Rings With More Than One Heteroatom; 2.6. Bicyclic Compounds; 2.7. Multicyclic Systems; 2.8. The Replacement Nomenclature System; 2.9. Saturated Bridged Ring Systems; References; Review Exercises 327 $aChapter 3 NATURE AS A SOURCE OF HETEROCYCLIC COMPOUNDS3.1. General; 3.2. Naturally Occurring Nitrogen Heterocyclic Compounds; 3.3. Oxygen Compounds; 3.4. Sulfur and Phosphorus Heterocyclic Compounds in Nature; References; Chapter 4 PRINCIPLES OF SYNTHESIS OF AROMATIC HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION; 4.1. General; 4.2. Some of the Classic Synthetic Methods; 4.3. Cyclizations Involving Metallic Complexes as Catalysts; 4.4. Cyclizations with Radical Intermediates; 4.5. Cyclizations by Intramolecular Wittig Reactions; 4.6. Synthesis of Heterocycles by the Alkene Metathesis Reaction 327 $aReferencesReview Exercises; Chapter 5 SYNTHESIS OF HETEROCYCLIC SYSTEMS BY CYCLOADDITION REACTIONS; 5.1. The Diels-Alder Reaction; 5.2. Dipolar Cycloadditions; 5.3. [2 + 2] Cycloadditions; References; Review Exercises; Chapter 6 AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-DEFICIENT RING SYSTEMS; 6.1. General; 6.2. Review of the Aromaticity of Benzene; 6.3. Pi-Deficient Aromatic Heterocycles; References; Review Exercises; Chapter 7 AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-EXCESSIVE RING SYSTEMS AND MESOIONIC RING SYSTEMS 327 $a7.1. Pi-Excessive Aromatic Heterocycles7.2. Mesoionic Heterocycles; References; Review Exercises; Chapter 8 THE IMPORTANCE OF HETEROCYCLES IN MEDICINE; 8.1. General; 8.2. Historical; 8.3. Pyridines; 8.4. Indoles; 8.5. Quinolines; 8.6. Azepines; 8.7. Pyrimidines; 8.8. Concluding Remarks; References; Chapter 9 SYNTHETIC METHODS FOR SOME PROMINENT HETEROCYCLIC FAMILIES: EXAMPLES OF PHARMACEUTICALS SYNTHESIS; 9.1. Scope of the Chapter; 9.2. Pyrroles; 9.3. Furans; 9.4. Thiophenes; 9.5. 1,3-Thiazoles; 9.6. 1,3-Oxazoles; 9.7. Imidazoles; 9.8. Pyrazoles; 9.9. 1,2,4-Triazoles; 9.10. Tetrazoles 327 $a9.11. 1,3,4-Thiadiazoles and other 5-Membered Systems9.12. Indole; 9.13. Pyridines; 9.14. Quinolines and Isoquinolines; 9.15. Benzodiazepines; 9.16. Pyrimidines; 9.17. Fused Pyrimidines: Purines and Pteridines; 9.18. 1,3,5-Triazines; 9.19. Multicyclic Compounds; References; Review Exercises; Chapter 10 GEOMETRIC AND STEREOCHEMICAL ASPECTS OF NONAROMATIC HETEROCYCLES; 10.1. General; 10.2. Special Properties of Three-Membered Rings; 10.3. Closing Heterocyclic Rings: Baldwin's Rules; 10.4. Conformations of Heterocyclic Rings; 10.5. Chirality Effects on Biological Properties of Heterocycles 327 $aReferences 330 $aHeterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularlyIntroduces students to heterocyclic chemistry and synthesis with practical examples of applied methodologyEmphasizes natural product and pharmaceutical applicationsProvides graduate students and researchers in the pharmaceutical and related sciences with a background in the fieldIncludes problem sets with several chapters 606 $aHeterocyclic chemistry 606 $aHeterocyclic compounds$xSynthesis 608 $aElectronic books. 615 0$aHeterocyclic chemistry. 615 0$aHeterocyclic compounds$xSynthesis. 676 $a547/.59 700 $aQuin$b Louis D.$f1928-$095510 701 $aTyrell$b John A$0896548 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458809103321 996 $aFundamentals of heterocyclic chemistry$92003100 997 $aUNINA LEADER 01627nam 2200349Ia 450 001 996389384203316 005 20221108094211.0 035 $a(CKB)4940000000094455 035 $a(EEBO)2240869938 035 $a(OCoLC)62369185 035 $a(EXLCZ)994940000000094455 100 $a20051129d1647 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA particular charge or impeachment in the name of his Excellency Sir Thomas Fairfax$b[electronic resource] $eand the army under his command, against Denzill Holles Esquire, Sir Philip Stapleton, Sir William Lewis ... 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