LEADER 01155cam0-22003371i-450- 001 990009521090403321 005 20120131113159.0 020 $aIT$b819278 035 $a000952109 035 $aFED01000952109 035 $a(Aleph)000952109FED01 035 $a000952109 100 $a20120131d1979----km-y0itaa50------ba 101 1 $aita$ceng 102 $aIT 200 1 $aAssistenza della gravidanza ad alto rischio e cura intensiva del neonato$fS. Gorham Babson ... [et al.]$gpresentazione del prof. Vito Albano$g1. ed. italiana a cura di P. Romano e P. Russo 210 $aPadova$cPiccin$d1979 215 $aXVI, 407 p.$cill.$d24 cm 454 0$12001$aManagement of high-risk pregnancy and intensive care of the neonate$960809 610 0 $aMedicina perinatale 676 $a618.92$v18 702 1$aRusso,$bPasquale$c 702 1$aBabson,$bSydney Gorham 702 1$aRomano,$bP. 801 0$aIT$bUNINA 901 $aBK 912 $a990009521090403321 952 $a90 U 3a 7$b985$fFMEBC 959 $aFMEBC 996 $aManagement of high-risk pregnancy and intensive care of the neonate$960809 997 $aUNINA LEADER 01329nam 2200337Ia 450 001 996389073403316 005 20210104172050.0 035 $a(CKB)4940000000096012 035 $a(EEBO)2248500548 035 $a(OCoLC)ocn857312579e 035 $a(OCoLC)857312579 035 $a(EXLCZ)994940000000096012 100 $a20130830d1647 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aWhereas upon Thursday last, December 16, 1647$b[electronic resource] $eThere came an unlicensed pamphlet abroad, under the base title of The bloody almanack, to the abuse of the kingdom, and set forth in the name of John Booker .. 210 $a[London $cs.n.$d1647] 215 $a1 sheet ([1] p.) 300 $aTitle from first lines of text. 300 $aSigned and dated at end: December 17 1647 John Booker. 300 $aPlace and date of publication suggested by Wing (2nd ed., 1994). 300 $aReproduction of original in: Worcester College (University of Oxford). Library. 330 $aeebo-0121 608 $aBooksellers' advertisements$zEngland$zLondon$y17th century.$2rbgenr 700 $aBooker$b John$f1603-1667.$01001751 801 0$bUMI 801 1$bUMI 906 $aBOOK 912 $a996389073403316 996 $aWhereas upon Thursday last, December 16, 1647$92342999 997 $aUNISA LEADER 04864nam 22005775 450 001 9910908379103321 005 20241113115727.0 010 $a9783031685507 010 $a3031685504 024 7 $a10.1007/978-3-031-68550-7 035 $a(CKB)36549457400041 035 $a(MiAaPQ)EBC31787495 035 $a(Au-PeEL)EBL31787495 035 $a(DE-He213)978-3-031-68550-7 035 $a(EXLCZ)9936549457400041 100 $a20241113d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTranscriptional Regulation by Neuronal Activity $eTo the Nucleus and Back /$fedited by Ramendra N. Saha, Serena M. Dudek 205 $a2nd ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (589 pages) 311 08$a9783031685491 311 08$a3031685490 327 $aSection 1: Activity-regulated Transcription: Getting to the Nucleus -- Fos/AP-1 as an exemplar for the study of neuronal activity-dependent gene regulation -- Calcium signaling to the nucleus -- Protein transport from synapse-to-nucleus and the regulation of gene expression -- Gene regulation by nuclear calcium and its antagonism by NMDAR/TRPM4 signaling -- Chemoelectric signaling, protein translocation and neuronal transcription -- Section 2: Activity-regulated Transcription: Epigenetic Regulation -- Histone variants in neuronal transcription and behavioral regulation -- Genome and epigenome engineering approaches to studying neuronal activity-dependent transcriptional enhancers -- Higher-order genome organization in the control of neuronal identity and neural circuit plasticity -- Chromatin remodelers in neuronal gene transcription -- Section 3: Activity-regulated Transcription: Role in Nervous System Function -- Nature and nurture converge in the nucleus to regulate activity-dependent neuronal development -- Roles for the MEF2 transcription factors in synapse and circuit development and plasticity -- Activity-related transcription: role in addiction -- Epigenetic priming of activity-dependent transcription in drug addiction -- Molecular intersection of activity-dependent gene expression and behavior: the transcriptomic signature of long-term memory consolidation -- Perturbations to stimulus-dependent gene activity patterns in neurodegenerative disorders -- Section 4: New Tools to Study and Use Activity-regulated Transcription -- Genome editing technologies for investigation of activity dependent transcription -- Imaging activity dependent gene expression in neurons: RNA tagging technologies -- Optogenetic approaches to study IEG activation -- New Genome-wide Technologies to Study Activity-regulated Transcription. 330 $aThis book discusses the regulation of gene transcription by neuronal activity that is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back, 2nd edition illustrates how signals are transmitted to the nucleus in response to neuronal activity, which genes are regulated and how this is achieved, and how these changes in gene expression alter neuronal function. The aim of this second edition is to highlight key advances in the field since the first edition. The book is divided into four sections. The first highlights how signals get to the nucleus from the membrane in response to synaptic or neuronal activity. Included are chapters on the pathways that transmit signals from synapses to nuclei. The second section focuses on epigenetic regulatory processes of activity-induced gene transcription, an area that has exploded in the past few years. The third section navigates the role of activity-induced genes in physiological processes such as learning and memory, and human developmental disorders such as those associated with the autism spectrum. The fourth section highlights groundbreaking technological advances in the field, which have allowed activity-regulated transcription to be used as a tool to study learning and memory. 606 $aNeurosciences 606 $aNeurology 606 $aGenetics 606 $aNeuroscience 606 $aNeurology 606 $aGenetics 615 0$aNeurosciences. 615 0$aNeurology. 615 0$aGenetics. 615 14$aNeuroscience. 615 24$aNeurology. 615 24$aGenetics. 676 $a612.8 700 $aSaha$b Ramendra N$01775912 701 $aDudek$b Serena M$01775913 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910908379103321 996 $aTranscriptional Regulation by Neuronal Activity$94291089 997 $aUNINA