LEADER 02337nam 2200457Ia 450 001 996387782103316 005 20200824132606.0 035 $a(CKB)4940000000086985 035 $a(EEBO)2264182981 035 $a(OCoLC)ocm51784512e 035 $a(OCoLC)51784512 035 $a(EXLCZ)994940000000086985 100 $a20030304d1648 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA helpe to discovrse: or, More merriment mixt with serious matters$b[electronic resource] $eConsisting of witty philosophicall, grammaticall, physicall, astronomicall questions and answers. As also, epigrams, epitaphs, riddles, jests, posies, love-toyes, &c. re-added and plentifully dispersed. Together with The country-mans counsellor, and his yearly oracle and prognostication, with additions, or a helpe to preserve his health, never before printed 205 $aThe 13th ed. 210 $aLondon $cPrinted by M.B. for L.B. and are to be sold by Andrew Crooke ...$d1648 215 $a[6], 375 [i.e. 386] p 300 $aImperfect: tightly bound, cropped with some loss of text. 300 $a"The Country-mans Counsellor ... by E.P." (p. [197]-251) and "Sphinx and Oedipus" (p. [267]-374) each have separate t. p., "printed for I.B. and are to be sold by Andrew Crook. 1648." 300 $aErrors in pagination: p.32 misnumbered 33; p. 134-135 misnumbered 235-235; p. 199 misnumbered 991; p. 258 misnumbered 158; p. 320-386 misnumbered 318-375. Some page numbers corrected by hand; some cropped and unreadable. 300 $aVariously attributed to William Basse, Edward Phillips and Edward Pond. Cf. Halkett & Laing (3rd ed.). 300 $aReproduction of original in: British Library. 330 $aeebo-0018 606 $aEpigrams, English$vEarly works to 1800 606 $aAlmanacs, English$vEarly works to 1800 606 $aAnecdotes$vEarly works to 1800 615 0$aEpigrams, English 615 0$aAlmanacs, English 615 0$aAnecdotes 700 $aE. P$01009390 702 $aBasse$b William$fd. ca. 1653, 702 $aPhillips$b Edward$f1630-1696?, 702 $aPond$b Edward$fd. 1629, 801 0$bEAE 801 1$bEAE 906 $aBOOK 912 $a996387782103316 996 $aA helpe to discovrse: or, More merriment mixt with serious matters$92389979 997 $aUNISA LEADER 03878nam 22006615 450 001 9910639878103321 005 20251009094542.0 010 $a9783031129742$b(electronic bk.) 010 $z9783031129735 024 7 $a10.1007/978-3-031-12974-2 035 $a(MiAaPQ)EBC7167832 035 $a(Au-PeEL)EBL7167832 035 $a(CKB)25936425400041 035 $a(DE-He213)978-3-031-12974-2 035 $a(OCoLC)1369656710 035 $a(BIP)084962175 035 $a(PPN)267807406 035 $a(EXLCZ)9925936425400041 100 $a20230101d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCancer Stem Cell Markers and Related Network Pathways /$fedited by Shihori Tanabe 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (163 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1393 311 08$aPrint version: Tanabe, Shihori Cancer Stem Cell Markers and Related Network Pathways Cham : Springer International Publishing AG,c2023 9783031129735 327 $a1. Epithelial-mesenchymal transition and cancer stem cells -- 2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistance -- 3. ERBB signaling pathway in cancer stem cells -- 4. Functional and molecular characters of cancer stem cells through devel-opment to establishment -- 5. Microenvironment in cancer stem cells -- 6. Cancer stem cells contribute to drug resistance in multiple different ways -- 7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic target. 330 $aThis book entitled ?Cancer Stem Cell Markers and Related Network Path-ways? is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in thefield of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1393 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMedical genetics 606 $aMedical microbiology 606 $aBiomedical Research 606 $aBiomedical Research 606 $aMedical Genetics 606 $aMedical Microbiology 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aMedical genetics. 615 0$aMedical microbiology. 615 14$aBiomedical Research. 615 24$aBiomedical Research. 615 24$aMedical Genetics. 615 24$aMedical Microbiology. 676 $a610.28 676 $a616.99407582 702 $aTanabe$b Shihori$4edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910639878103321 996 $aCancer Stem Cell Markers and Related Network Pathways$93003347 997 $aUNINA