LEADER 01759nam 2200445Ia 450 001 996386537003316 005 20200824132748.0 035 $a(CKB)4940000000081827 035 $a(EEBO)2240949396 035 $a(OCoLC)ocm15277240e 035 $a(OCoLC)15277240 035 $a(EXLCZ)994940000000081827 100 $a19870306d1675 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aArs pictoria, or, An academy treating of drawing, painting, limning, etching$b[electronic resource] $eto which are added XXXI copper plates expressing the choicest, nearest and most exact grounds and rules of symmetry /$fcollected out of the most eminent Italian, German, and Netherland authors by Alexander Browne .. 205 $aThe second edition /$bcorrected and enlarged by the author. 210 $aLondon $cPrinted for Arthur Tooker ... and William Battersby ...$d1675 215 $a165 p. in various pagings, [32] leaves of plates $cill., port 300 $aWith: an appendix to the art of painting in miniature, or limning ... / by Alexander Browne. 300 $aReproduction of original in the British Library. 330 $aeebo-0018 606 $aArt$xTechnique$vEarly works to 1800 606 $aDrawing$y17th century 606 $aEtching$y17th century 606 $aPainting$vEarly works to 1800 615 0$aArt$xTechnique 615 0$aDrawing 615 0$aEtching 615 0$aPainting 700 $aBrowne$b Alexander$ffl. 1660-1677.$01002391 801 0$bEAJ 801 1$bEAJ 801 2$bm/c 801 2$bEAJ 801 2$bWaOLN 906 $aBOOK 912 $a996386537003316 996 $aArs pictoria, or, An academy treating of drawing, painting, limning, etching$92300690 997 $aUNISA LEADER 02664nam 2200385z- 450 001 9910688238003321 005 20210211 035 $a(CKB)3710000000612069 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48416 035 $a(oapen)doab48416 035 $a(EXLCZ)993710000000612069 100 $a20202102d2014 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGenome-wide view on the physiology of vitamin D 210 $cFrontiers Media SA$d2014 215 $a1 online resource (194 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-349-7 330 $aThe main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980's. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer. 606 $aPhysiology$2bicssc 610 $aGenomics 610 $aImmune System 610 $aPhysiology 610 $aVitamin D 610 $avitamin D receptor 615 7$aPhysiology 700 $aCarsten Carlberg$4auth$0849346 906 $aBOOK 912 $a9910688238003321 996 $aGenome-wide view on the physiology of vitamin D$93122472 997 $aUNINA