LEADER 04550nam 22006015 450 001 996418272103316 005 20200702140129.0 010 $a3-030-40105-7 024 7 $a10.1007/978-3-030-40105-4 035 $a(CKB)4100000011273785 035 $a(MiAaPQ)EBC6188721 035 $a(DE-He213)978-3-030-40105-4 035 $a(PPN)248396668 035 $a(EXLCZ)994100000011273785 100 $a20200501d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDesign and Analysis of Subgroups with Biopharmaceutical Applications$b[electronic resource] /$fedited by Naitee Ting, Joseph C. Cappelleri, Shuyen Ho, (Din) Ding-Geng Chen 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (404 pages) 225 1 $aEmerging Topics in Statistics and Biostatistics ,$x2524-7735 311 $a3-030-40104-9 327 $a1. Data-driven and Confirmatory Subgroup Analysis in Clinical Trials -- 2. Subgroup Analysis ? A View from Industry -- 3. Biomarker-Targeted Confirmatory Trials -- 4. Considerations on Subgroup Analysis in Design and Analysis of Multi-Regional Clinical Trials -- 5. Practical Subgroup Identification Strategies in Late-stage Clinical Trials -- 6. Exploratory Subgroup Identification for Biopharmaceutical Development -- 7. Logical Inference on Treatment Efficacy When Subgroup Exists -- 8. The GUIDE Approach to Subgroup Identification and Inference -- 9. Use of the VG (Virtual Twins Combined with GUIDE) Method in the Development of Precision Medicines -- 10. Subgroups Identification for Tailored Therapies: a System of Methods, a Framework for Consistent Methodology Evaluation, and an Integrated Learn-and-confirm Approach -- 11. Developing and Validating Predictive Classifiers in Randomized Clinical Trials -- 12. Issues Related to Subgroup Analysis -- 13. Subgroup Analysis with Partial Linear Model -- 14. Subgroup Analysis in the 21st Century -- 15. Power of Statistical Tests for Subgroup Analysis in Meta-Analysis -- 16. Heterogeneity and Subgroup Analysis in Network Meta-Analysis. 330 $aThis book provides an overview of the theories and applications on subgroups in the biopharmaceutical industry. Drawing from a range of expert perspectives in academia and industry, this collection offers an overarching dialogue about recent advances in biopharmaceutical applications, novel statistical and methodological developments, and potential future directions. The volume covers topics in subgroups in clinical trial design; subgroup identification and personalized medicine; and general issues in subgroup analyses, including regulatory ones. Included chapters present current methods, theories, and case applications in the diverse field of subgroup application and analysis. Offering timely perspectives from a range of authoritative sources, the volume is designed to have wide appeal to professionals in the pharmaceutical industry and to graduate students and researchers in academe and government. 410 0$aEmerging Topics in Statistics and Biostatistics ,$x2524-7735 606 $aStatistics  606 $aBiostatistics 606 $aPharmaceutical technology 606 $aStatistics for Life Sciences, Medicine, Health Sciences$3https://scigraph.springernature.com/ontologies/product-market-codes/S17030 606 $aBiostatistics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15020 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 615 0$aStatistics . 615 0$aBiostatistics. 615 0$aPharmaceutical technology. 615 14$aStatistics for Life Sciences, Medicine, Health Sciences. 615 24$aBiostatistics. 615 24$aPharmaceutical Sciences/Technology. 676 $a615.10727 702 $aTing$b Naitee$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCappelleri$b Joseph C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHo$b Shuyen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChen$b (Din) Ding-Geng$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996418272103316 996 $aDesign and Analysis of Subgroups with Biopharmaceutical Applications$92547801 997 $aUNISA LEADER 01373nam 2200373Ia 450 001 996385909503316 005 20221108062726.0 035 $a(CKB)1000000000610207 035 $a(EEBO)2240863559 035 $a(OCoLC)16317480 035 $a(EXLCZ)991000000000610207 100 $a19870730d1695 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aEphemeris absoluta$b[electronic resource] $ean almanack astronomical, astrological, meteorological for the year of our Lord God 1695 : and from the world's creation 5644 : being the third after bissextile, or leap-year : wherein is contain'd the motions of the planets, mutual and lunar aspects ... : accommodated and referred ... to ... London ... /$fby Daniel Woodward .. 210 $aLondon $cPrinted by J.D. for the Company of Stationers$d[1695] 215 $a[48] p 300 $aReproduction of original in the Bodleian Library. 330 $aeebo-0014 606 $aAlmanacs, English 606 $aEphemerides 606 $aAstrology$vEarly works to 1800 615 0$aAlmanacs, English. 615 0$aEphemerides. 615 0$aAstrology 700 $aWoodward$b Daniel$ffl. 1682-1700.$01003662 801 0$bEAK 801 1$bEAK 801 2$bEAA 801 2$bWaOLN 906 $aBOOK 912 $a996385909503316 996 $aEphemeris absoluta$92304674 997 $aUNISA LEADER 02262oam 2200589 450 001 9910707849803321 005 20161216162117.0 035 $a(CKB)5470000002468061 035 $a(OCoLC)885281942 035 $a(EXLCZ)995470000002468061 100 $a20140805d1980 ua 0 101 0 $aeng 135 $aurbn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStratigraphy, preliminary petrology, and some structural features of Tertiary volcanic rocks in the Gabbs Valley and Gillis Ranges, Mineral County, Nevada /$fby E.B. Ekren, F.M. Byers, Jr., R.F. Hardyman, R.F. 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M$g(Frank M.),$f1916- 702 $aHardyman$b Richard F. 702 $aMarvin$b Richard F. 702 $aSilberman$b Miles L. 712 02$aGeological Survey (U.S.), 801 0$bCOP 801 1$bCOP 801 2$bOCLCO 801 2$bOCLCF 801 2$bGPO 906 $aBOOK 912 $a9910707849803321 996 $aStratigraphy, preliminary petrology, and some structural features of Tertiary volcanic rocks in the Gabbs Valley and Gillis Ranges, Mineral County, Nevada$93468794 997 $aUNINA