LEADER 03062oam 2200493 450 001 9910484627203321 005 20210604130723.0 010 $a3-030-61121-3 024 7 $a10.1007/978-3-030-61121-7 035 $a(CKB)4100000011665269 035 $a(DE-He213)978-3-030-61121-7 035 $a(MiAaPQ)EBC6426751 035 $a(PPN)252515218 035 $a(EXLCZ)994100000011665269 100 $a20210604d2020 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHeterogeneity in statistical genetics $ehow to assess, address, and account for mixtures in association studies /$fDerek Gordon, Stephen J. Finch, Wonkuk Kim 205 $a1st ed. 2020. 210 1$aCham, Switzerland :$cSpringer,$d[2020] 210 4$d©2020 215 $a1 online resource (XX, 352 p. 41 illus., 26 illus. in color.) 225 1 $aStatistics for Biology and Health,$x1431-8776 311 $a3-030-61120-5 320 $aIncludes bibliographical references and index. 327 $a1. Introduction to heterogeneity in statistical genetics -- 2. Overview of genomic heterogeneity in statistical genetics -- 3. Phenotypic heterogeneity -- 4. Association tests allowing for heterogeneity -- 5. Designing genetic linkage and association studies that maintain desired statistical power in the presence of mixtures -- 6. Threshold-selected quantitative trait loci and pleiotropy -- Index. 330 $aHeterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design. 410 0$aStatistics for Biology and Health,$x1431-8776 606 $aStatistics 615 0$aStatistics. 676 $a572.80727 700 $aGordon$b Derek$0947023 702 $aFinch$b Stephen J. 702 $aKim$b Wonkuk. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910484627203321 996 $aHeterogeneity in statistical genetics$92139692 997 $aUNINA LEADER 01961nam 2200421 n 450 001 996385359303316 005 20230120001033.0 035 $a(CKB)1000000000608201 035 $a(EEBO)2248512818 035 $a(UnM)99844998e 035 $a(UnM)99844998 035 $a(EXLCZ)991000000000608201 100 $a19910916d1598 uy | 101 0 $aeng 135 $aurbn#|||a|bb| 200 14$aThe description of a voyage made by certaine ships of Holland into the East Indies$b[electronic resource] $eVVith their aduentures and successe: together with the description of the countries, townes, and inhabitantes of the same: who set forth on the second of Aprill 1595. and returned on the 14. of August. 1597. Translated out of Dutch into English by W.P 210 $aLondon $cImprinted by [John Windet? for] Iohn Wolfe$d1598 215 $a[4], 40 leaves $cill. (woodcuts), maps 300 $aSometimes attributed to Cornelius de Houtman, who was commander of the voyage. 300 $aA translation of: Verhael vande reyse by de Hollandtsche schepen gedaen naer Oost Indiennez. 300 $aTranslator's dedication signed: W. Phillip. 300 $aForeword signed by the publisher of the Dutch edition: Bernardt Langhenez. 300 $aActual printer's name conjectured by STC. 300 $aRunning title reads: The foure Hollanders ships voyage. 300 $aReproduction of the original in the Henry E. Huntington Library and Art Gallery. 330 $aeebo-0113 607 $aJava (Indonesia)$xDescription and travel$vEarly works to 1800 701 $aPhillip$b William$01001582 701 $aLangenes$b Barent$01004065 702 $aHoutman$b Cornelis de$f-1599, 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996385359303316 996 $aThe description of a voyage made by certaine ships of Holland into the East Indies$92306063 997 $aUNISA