LEADER 01257nam 2200325Ia 450 001 996384469303316 005 20221107231326.0 035 $a(CKB)4940000000075799 035 $a(EEBO)2240961217 035 $a(OCoLC)12248715 035 $a(EXLCZ)994940000000075799 100 $a19850710d1642 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 10$aNew observations dedicated to the Kings most excellent Majestie from all his loving subjects concerning peace$b[electronic resource] $eand hvmbly presented to the honorable House of Commons for their incouragement to the perfection of that good worke of peace and union in the church and state /$fby J. B. .. 210 $a[London] $cPrinted for George Tomlinson$d1642 215 $a8 p 300 $aReproduction of original in Thomason Collection, British Library. 330 $aeebo-0158 607 $aGreat Britain$xHistory$yCharles I, 1625-1649 700 $aJ. B$cCa. Pe.$01013703 801 0$bEAA 801 1$bEAA 801 2$bm/c 801 2$bUMI 801 2$bWaOLN 906 $aBOOK 912 $a996384469303316 996 $aNew observations dedicated to the Kings most excellent Majestie from all his loving subjects concerning peace$92358497 997 $aUNISA LEADER 03614nam 2200469 450 001 9910640390503321 005 20230531121418.0 010 $a3-031-18070-4 024 7 $a10.1007/978-3-031-18070-5 035 $a(MiAaPQ)EBC7168740 035 $a(Au-PeEL)EBL7168740 035 $a(DE-He213)978-3-031-18070-5 035 $a(PPN)267807376 035 $a(EXLCZ)9925945679800041 100 $a20230507d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMRNA vaccines /$fedited by Dong Yu and Benjamin Petsch 205 $a1st ed. 2022. 210 1$aCham, Switzerland :$cSpringer,$d[2023] 210 4$dİ2023 215 $a1 online resource (215 pages) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v437 311 08$aPrint version: Yu, Dong MRNA Vaccines Cham : Springer International Publishing AG,c2023 9783031180699 327 $aPreface -- mRNA-based vaccines and mode of action -- Self-Amplifying mRNA-Based Vaccine Technology and its Mode of Action -- Formulation and Delivery Technologies for mRNA Vaccines -- Messenger RNA-based vaccines against infectious diseases -- Emerge gate for Therapeutics applications of mRNA based drug -- Clinical Development of mRNA Vaccines: Challenges and Opportunities -- Regulatory Considerations on the Development of mRNA Vaccines. 330 $aThe formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic, low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health. As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. 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Bourne 205 $a1st ed. 210 $aBasel : $cS. Karger, $d1978 215 $a1 online resource (X + 222 pages) : $c 35 figures, 17 tables 225 1 $aIssn Series 311 08$a9783805528559 311 08$a3805528558 327 $a978-3-8055-2855-9_Cover -- 978-3-8055-2855-9_00I -- 978-3-8055-2855-9_001 -- 978-3-8055-2855-9_027 -- 978-3-8055-2855-9_049 -- 978-3-8055-2855-9_096 -- 978-3-8055-2855-9_123 -- 978-3-8055-2855-9_135 -- 978-3-8055-2855-9_165 -- 978-3-8055-2855-9_198 -- 978-3-8055-2855-9_213. 410 0$aIssn Series 606 $aNutrition 606 $aMetabolism 606 $aGastroenterology 606 $aPharmaceutics 606 $aPharmacology 606 $aVeterinary Medicine 615 14$aNutrition 615 14$aMetabolism 615 24$aGastroenterology 615 24$aPharmaceutics 615 24$aPharmacology 615 24$aVeterinary Medicine 676 $a612.3 s 676 $a613.2 700 $aBourne$b G.H 701 $aBourne$b Geoffrey H$g(Geoffrey Howard),$f1909-1988.$063248 801 0$bUKSKG 801 1$bUKSKG 906 $aBOOK 912 $a9910158695803321 996 $aHuman and Animal Nutrition$92858618 997 $aUNINA