LEADER 00904nam0-2200277---450- 001 990009270980403321 005 20101028093005.0 035 $a000927098 035 $aFED01000927098 035 $a(Aleph)000927098FED01 035 $a000927098 100 $a20101028d1938----km-y0itay50------ba 101 0 $aeng 102 $aGB 105 $a--------001yy 200 1 $aCapital investment in Africa$eits course and effects$fS. Herbert Frankel$gissued by the Committee of the African Research Survey under the auspices of the Royal Institute of International Affairs 210 $aLondon [etc.]$cOxford University Press$d1938 215 $aXVI, 487 p.$d23 cm 700 1$aFrankel,$bS. Herbert$0123682 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990009270980403321 952 $aN04.85$fDECTS 959 $aDECTS 996 $aCapital investment in Africa$9773503 997 $aUNINA LEADER 01435nas 22004332a 450 001 996297346003316 005 20240413012555.0 035 $a(CKB)991042754056056 035 $a(CONSER)sn-98001015- 035 $a(EXLCZ)99991042754056056 100 $a19980706a19989999 --- - 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCountry review$iMalta 210 $aHouston, TX $cCommercial Data International 215 $a1 online resource 311 08$aPrint version: Country review. 1520-0876 (DLC)sn 98001015 (OCoLC)39396106 517 3 $aMalta 606 $aEcology$2fast$3(OCoLC)fst00901476 606 $aEconomic history$2fast$3(OCoLC)fst00901974 606 $aPolitics and government$2fast$3(OCoLC)fst01919741 606 $aSocial conditions$2fast$3(OCoLC)fst01919811 607 $aMalta$xEconomic conditions$y1964-$vPeriodicals 607 $aMalta$xEnvironmental conditions$vPeriodicals 607 $aMalta$xPolitics and government$y1964-$vPeriodicals 607 $aMalta$xSocial conditions$vPeriodicals 607 $aMalta$2fast 608 $aPeriodicals.$2fast 615 7$aEcology. 615 7$aEconomic history. 615 7$aPolitics and government. 615 7$aSocial conditions. 906 $aJOURNAL 912 $a996297346003316 920 $aexl_impl conversion 996 $aCountry review$92425273 997 $aUNISA LEADER 04292nam 22006495 450 001 9910298335203321 005 20200629215958.0 010 $a1-4939-1683-1 024 7 $a10.1007/978-1-4939-1683-2 035 $a(CKB)3710000000261813 035 $a(EBL)1965022 035 $a(OCoLC)894508684 035 $a(SSID)ssj0001372163 035 $a(PQKBManifestationID)11831404 035 $a(PQKBTitleCode)TC0001372163 035 $a(PQKBWorkID)11301847 035 $a(PQKB)11517881 035 $a(MiAaPQ)EBC1965022 035 $a(DE-He213)978-1-4939-1683-2 035 $a(PPN)182093883 035 $a(EXLCZ)993710000000261813 100 $a20141020d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular Genetics of Dysregulated pH Homeostasis /$fedited by Jen-Tsan Ashley Chi 205 $a1st ed. 2014. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2014. 215 $a1 online resource (158 p.) 300 $aDescription based upon print version of record. 311 $a1-4939-1682-3 320 $aIncludes bibliographical references at the end of eah chapters and index. 327 $aMolecular Genetics of Acid Sensing and Response -- Part I: Sensing Acidity -- The molecular mechanism of cellular sensing of acidity -- The Molecular Basis of Sour Sensing in Mammals -- Function and Signaling of the pH-sensing G protein-coupled receptors in physiology and diseases -- Part II: Response to Acidity -- The MondoA-TXNIP checkpoint couples the acidic tumor microenvironment to cell metabolism -- Regulation of Renal Glutamine Metabolisms during Metabolic Acidosis -- Extracellular acidosis and cancer -- The genomic analysis of cellular responses and adaptions to extracellular acidosis -- Index. 330 $aMost biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological function at every level, including protein folding, enzymatic activities and proliferation, and cell death. Therefore, maintaining the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in scientific literature and in medical textbooks.  However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events, and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases including cancer, stroke, myocardial infarction, diabetes, and renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and respond to acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanisms and cellular responses to pH alterations in both physiological (taste, pain) and pathological (ischemia and cancers) settings. Furthermore, the authors present a broad spectrum of investigative approaches to cellular response to acidosis in a wide variety of human diseases. 606 $aHuman genetics 606 $aCytology 606 $aMedicine 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aHuman genetics. 615 0$aCytology. 615 0$aMedicine. 615 14$aHuman Genetics. 615 24$aCell Biology. 615 24$aBiomedicine, general. 676 $a571.6 676 $a599935 676 $a610 676 $a611.01816 702 $aChi$b Jen-Tsan Ashley$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298335203321 996 $aMolecular Genetics of Dysregulated pH Homeostasis$92513121 997 $aUNINA